Overview
- Editors:
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William M. Shafer
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Emory University School of Medicine, Atlanta
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Table of contents (17 protocols)
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Origins and Development of Peptide Antibiotic Research
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Isolation and Characterization of Antibacterial Peptides
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- Charles Hetru, Philippe Bulet
Pages 35-49
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- Shun-ichiro Kawabata, Sadaaki Iwanaga
Pages 51-61
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- Tatsushi Muta, Sadaaki Iwanaga
Pages 63-71
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- Martha M. Juban, Maryam M. Javadpour, Mary D. Barkley
Pages 73-78
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- Martha M. Juban, Maryam M. Javadpour, Mary D. Barkley
Pages 79-84
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- Xiaotang Wang, Kathleen M. Morden
Pages 85-112
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Molecular Biology of Antibacterial Peptides
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- Erika V. Valore, Tomas Ganz
Pages 115-131
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- Alessandro Tossi, Marco Scocchi, Margherita Zanetti, Renato Gennaro, Paola Storici, Domenico Romeo
Pages 133-150
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- Charles L. Bevins, Gill Diamond
Pages 151-166
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Assay Systems for Studying Antibacterial Peptides
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- Deborah A. Steinberg, Robert I. Lehrer
Pages 169-186
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- Shafique Fidai, Susan W. Farmer, Robert E. W. Hancock
Pages 187-204
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- Eduardo A. Groisman, Arden Aspedon
Pages 205-215
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- Daniel J. Brackett, Megan R. Lerner, H. Anne Pereira
Pages 247-255
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Back Matter
Pages 257-259
About this book
As this book. Antibacterial Peptide Protocols, will attest, my enthusi asm for the field of antibacterial peptides is based on a conviction (and I am unashamed to say, prejudice) that these substances are in essence antibiotics produced by the host that then participate in host defense against infectious agents. Because of their capacity to exert antibiotic-like action against patho genic microorganisms (bacteria, fungi, parasites, and viruses), there is reason to believe that these agents will soon be used clinically to treat infectious diseases. In fact, in recent years, biotechnology companies have been formed for the sole purpose of developing antibacterial peptides for clinical use. It should be emphasized that antibacterial peptides will likely play a major role in the treatment of infectious diseases, particularly with the increasing prob lem of multidrug-resistant microbes and the relative dearth of new antibiotics being provided by pharmaceutical companies. The topic of this volume of Methods in Molecular Biology, the diverse methods used in research on antibacterial peptides, is thus quite timely. As the subject of antibacterial peptides develops into its own discipline (something strongly suggested by the explosion in the number of papers published over the past decade), it is essential that reliable techniques and strategies be made available not only to those of us in the field, but also to the newcomers and researchers in complementary disciplines.
Editors and Affiliations
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Emory University School of Medicine, Atlanta
William M. Shafer