Abstract
All living organisms are constantly confronted by invading microbes. In mammals, host defense against microbial invasion requires specialized cellular and extracellular elements in blood and a complex signalling machinery that triggers their mobilization to extravascular sites of invasion in a highly regulated manner. This process is driven by microbe-specific signals, including highly conserved and chemically unique microbial (envelope) components, such as Gram-negative bacterial lipopolysaccharides (LPS) (1,2).
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Weiss, J. (1997). Assay of Antibacterial Activities of the Bactericidal/Permeability-Increasing Protein in Natural Biological Fluids. In: Shafer, W.M. (eds) Antibacterial Peptide Protocols. Methods In Molecular Biology™, vol 78. Humana Press. https://doi.org/10.1385/0-89603-408-9:217
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DOI: https://doi.org/10.1385/0-89603-408-9:217
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