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Amyloid-independent pathogenesis for Alzheimerās disease: implications for drug design Michael S. Wolfe Review Article 18 June 2024
Sulfur (VI) fluoride exchange (SuFEx): a versatile tool to profile protein-biomolecule interactions for therapeutic development Lingyun YangZhengnan YuanBingchen Yu Review Article 18 June 2024
Docking-guided exploration of the anti-flt3 potential of isoindigo derivatives towards potential treatments of acute myeloid leukemia Mazen Al SulaibiJalal ZahraMutasem O. Taha Original Research Article 17 June 2024
Reversible in-situ assembly of PROTACs using iminoboronate conjugation Ce YangYayun XieBinghe Wang Original Research Article 15 June 2024
N-Benzyl, N-phenethyl and N-benzyloxybenzamide derivatives inhibit amyloid-beta (AĪ²42) aggregation and mitigate AĪ²42-induced neurotoxicity Yusheng ZhaoArash ShakeriPraveen P. N. Rao Original Research Article 15 June 2024
Advances in anticancer applications of platinum(II) complexes of dithiocarbamates Saeed Ahmad Review Article 15 June 2024
In silico drug discovery: a machine learning-driven systematic review Sema Atasever Review Article 15 June 2024
Development of novel fluoro-substituted rivastigmine derivatives as selective AChE inhibitors for the treatment of AD Zhengwei LiuXinjuan LiZhipei Sang Original Research Article 14 June 2024
Pharmacological assessment of disulfideātriazine hybrids: synthesis, enzyme inhibition, and molecular docking study Fikret TĆ¼rkanAdnan CetinDanuta Branowska Original Research Article 14 June 2024
Revolutionizing drug discovery: an AI-powered transformation of molecular docking Adeola Abraham FadahunsiHenrietta Onyinye UzoetoArome Solomon Odiba Review Article 14 June 2024
Unlocking therapeutic potential: exploring indole scaffolds and their structural insights as pharmacophores in designing anti-breast cancer agents Adithya VinodH. M. Chandra MouliRamalingam Peraman Review Article 12 June 2024
Current trends and future directions for the synthesis and pharmacological applications of 2-(2-cyanopyrrolidin-1-yl)-N-3-hydroxyadamantan-1-yl) acetamide (Gliptins) Shaikh YahyaMohammad Usman ShaikhM. Shahar Yar Review Article 11 June 2024
Position switch of phenylthiazoles: novel compounds with promising anti-MRSA USA300 Abdelrahman A. AbuelkhirMariam OmaraMohamed Hagras Original Research Article 10 June 2024
Glutathione transporter as a target for brain drug delivery Xiangming Guan Review Article Open access 10 June 2024
New sirtuin modulators: their uncovering, pharmacophore, and implications in drug discovery Pei-Ti ChenKeng Yoon Yeong Review Article Open access 08 June 2024
Discovering cholinesterase inhibitors from Chinese herbal medicine with deep learning models Fulu PanYang LiuYanli Pan Original Research Article 08 June 2024
Correction to: Structure-activity relationships and pharmacokinetic evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria Longqin HuHaifa AlbanyanAmrik Sahota Correction Open access 07 June 2024
Neuroprotective role of nobiletin against amyloid-Ī² (AĪ²) aggregation in Parkinson and Alzheimer disease as neurodegenerative diseases of brain Vahid AlivirdilooMobasher HajiabbasiAmin mehra Review Article 07 June 2024
Synthesis and characterization of new tetrakisphosphonic acid derivatives as FPPS inhibitors and evaluation of their anti-osteoclastogenic potential for prevention of osteoporosis A. M. A. HassanMarwa El-HussienyManal Abdel Fattah Ezzat Original Research Article 05 June 2024
Synthesis and antiviral property of polysulfate-grafted maleimide-based enediynes Zhuoyu LiZhe DingAiguo Hu Original Research Article 03 June 2024 Pages: 1024 - 1030
Design and synthesis of novel factor XIa Inhibitors with bicyclic isoquinoline and naphthalene fragments Yi ZhangLinjun DaiQing Li Original Research Article 30 May 2024 Pages: 1003 - 1023
Design and synthesis of benzo[d]imidazo-6,7-dihydrobenzo[d] imidazo[2,1-b]thiazol-8(5H)-ones as potent anti-infective agents Rakesh K. BollikandaYana L. EsaulkovaSrinivas Kantevari Original Research Article 28 May 2024 Pages: 989 - 1002
Design and synthesis of indole-based elipticine analogues as topoisomerase IIĪ² inhibitors Mardia T. El SayedAlaadin E. SarhanMamdouh M. Ali Original Research Article 28 May 2024 Pages: 885 - 902
Exploring nucleoside analogs: key targets in the viral life cycle - advancing strategies against SARS-CoV-2 Roopal GargRaveen KumarRicha Srivastava Review Article 28 May 2024 Pages: 869 - 884
A study of alkene disulfonoxylation Shyam SathyamoorthiSteven P. Kelley Original Research Article 28 May 2024
Discovery of cytotoxic truncated vitamin D derivatives against both bortezomibāsensitive and bortezomibāresistant multiple myeloma phenotypes Mohamed O. RadwanSawa SakaiMikako Fujita Original Research Article 24 May 2024 Pages: 829 - 837
Correction: Bioassay-guided fractionations of Cannabis sativa extract and HPLC-assisted purifications of anti-proliferative active fractions lead to the isolation of 16 known and one new phytomolecule and their in-silico analysis Yedukondalu NalliSahil BhartiMahendra Kumar Verma Correction 22 May 2024 Pages: 838 - 838
Structural simplification and ester bond flipping lead to bis-benzodioxole derivatives as potential hypolipidemic and hepatoprotective agent Yundong XieSiyao WangShipeng He Original Research Article 22 May 2024 Pages: 811 - 828
Morpholinated curcuminoids against urinary bladder cancer cells: synthesis and anticancer evaluation Pawel BakunMalgorzata KucinskaTomasz Goslinski Original Research Article Open access 22 May 2024 Pages: 944 - 963
Synthesis and in vitro biological activity of chalcone derivatives as potential antiparasitic agents Koketso J. SetshediRichard M. BeteckLesetja J. Legoabe Original Research Article Open access 21 May 2024 Pages: 977 - 988
Discovery of HNPC-A188: a novel acaricide containing trifluoroethyl thioether and pyrimidin-4-amine Ting XiaoAiping LiuWeidong Liu Original Research Article 20 May 2024 Pages: 930 - 943
The emergence of sulfo-click amidation in kinetic target-guided synthesis Prakash T. ParvatkarRoman Manetsch Review Article Open access 18 May 2024
Development of semisynthetic saponin immunostimulants Di BaiHyunjung KimPengfei Wang Review Article Open access 18 May 2024
A very promising antibiofilm activity against Candida albicans from an in vitro screening for antimicrobial, antibiofilm and antiproliferative activity of new synthesized 4-cinnamamido- and 2-phenoxyacedamido-1H-pyrazol-5-yl)benzamides Fabiana PlesciaValentina CataniaDomenico Schillaci Original Research Article Open access 15 May 2024 Pages: 903 - 917
Candida albicans ergosterol disorders as a consequence of the new sulfone derivative action mode Monika StaniszewskaMichalina KazekZbigniew Ochal Original Research Article Open access 14 May 2024 Pages: 964 - 976
Naturally occurring and artificially designed antimicrobial peptides: a comparative study of Mastoparan C and BP52 Hai Bui Thi PhuongYen Do HaiHuy Luong Xuan Brief Report 13 May 2024 Pages: 735 - 739
Recent pharmacological insights about imidazole hybrids: a comprehensive review Samet PoyrazMetin YıldırımMehmet Ersatir Review Article 13 May 2024 Pages: 839 - 868
Synthesis of novel benzothieno-[3,2ā-f][1,3] oxazepines and their isomeric 2-oxo-2H-spiro[benzothiophene-3,3ā-pyrrolines] via 1,4-dipolar cycloaddition reaction and their evaluation as cytotoxic anticancer leads Mohammed M. Al-MahadeenAreej M. JaberMutasem O. Taha Original Research Article 11 May 2024 Pages: 918 - 929
Folate-conjugated organic CO prodrugs: Synthesis and CO release kinetic studies Shameer M. KondengadanShubham BansalBinghe Wang Original Research Article 10 May 2024
Structure-activity relationships and pharmacokinetic evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria Longqin HuHaifa AlbanyanAmrik Sahota Original Research Article Open access 07 May 2024
Molecular hybridization method for obtaining paeonol-based fibrate derivatives with potent lipid-lowering and hepatoprotective activity Lina QuanYing GuoYundong Xie Original Research Article 06 May 2024 Pages: 796 - 810
Role of natural secondary metabolites as HIF-1 inhibitors in cancer therapy Prem Shankar MishraRakhi MishraSamiksha Dewangan Review Article 02 May 2024 Pages: 721 - 734
Characterization of the CO release properties of a common CO donor, CORM-401, in the context of its application in studying CO biology Nicola BauerQiyue MaoBinghe Wang Original Research Article 18 April 2024
Antitumor studies on celastrol and its derivatives as RORĪ± agonists and RORĪ³ inhibitors based on Alphafold reverse docking strategy Bangwen YueXiuli Wu Original Research Article 12 April 2024 Pages: 779 - 795
Phenoxyalkyl cyclic and acyclic amine derivatives: what do they teach us about scaffold-based drug design? Mohammad Mahdi RezaeifarArdavan AbiriYaghoub Pourshojaei Review Article 10 April 2024 Pages: 703 - 720
Synthesis and anticancer activity of novel coumarin-stilbene hybrids with different hydrocarbon chains as linkers Lamya A. Al-lehaibEhab M. M. AliReda M. El-Shishtawy Original Research Article 05 April 2024 Pages: 764 - 778
Vital residues-orientated rational design of butenolide inhibitors targeting Of ChtI Qing HanYun-Jiang ZiHong-Xia Duan Brief Report 02 April 2024 Pages: 740 - 747
Design, synthesis and antitumor activity evaluation of novel benzamide HDAC inhibitors Ci CaiYepeng Luan Original Research Article 28 March 2024 Pages: 748 - 763
Design, synthesis, and in vitro biological evaluation of novel HDAC inhibitors bearing C-1 phenyl substituted tetrahydroisoquinoline Cap moiety as anti-tumor therapeutic agents Jie WangChi ZhouLei Liu Original Research Article 27 March 2024 Pages: 687 - 702