Articles

1. Driving sustainability through adoption of hybrid manufacturing in small molecule API production

   • Svetlana Borukhova
   • Robert Sebastian Rönnback

   Perspectives 22 March 2024 Pages: 303 - 312

   

2. Efficient pinnick oxidation by a superheated micro-reaction process

   • Jinpei Huang
   • Yongxiang Li
   • Yifeng Zhou

   Full Paper 20 March 2024

   

3. Rapid prototyping of a modular optical flow cell for image-based droplet size measurements in emulsification processes

   • Inga Burke
   • Christina Assies
   • Norbert Kockmann

   Full Paper Open access 19 March 2024

   

4. Emerging Investigators in Flow Chemistry 2023

   • Cecilia Bottecchia
   • Wu Jie
   • Luca Capaldo

   Editorial 18 March 2024 Pages: 1 - 9

   

5. Determination of micromixing times in commercially available continuous-flow mixers: evaluation of the incorporation and interaction by exchange with the mean model

   • Jasper H. A. Schuurmans
   • Micha Peeters
   • Koen P. L. Kuijpers

   Full Paper 06 March 2024 Pages: 33 - 42

   

6. Access semi-stabilized and unstabilized diazo compounds using iodosylbenzene

   • Laurent Vinet
   • Emmanuelle M. D. Allouche
   • André B. Charette

   Full Paper 29 February 2024 Pages: 109 - 118

   

7. 3D-printed open-source sensor flow cells for microfluidic temperature, electrical conductivity, and pH value determination

   • Robin Dinter
   • Lennart Helwes
   • Norbert Kockmann

   Full Paper Open access 28 February 2024

   

8. Design and structural parameter optimization of Venturi-type microbubble reactor for wastewater treatment by CFD simulation

   • Hanfei Liu
   • Chao Li
   • Kai Guo

   Full Paper 27 February 2024 Pages: 161 - 176

   

9. Lab-scale flow chemistry? Just do it yourself!

   • Laura Y. Vázquez-Amaya
   • Guglielmo A. Coppola
   • Upendra K. Sharma

   Review 23 February 2024 Pages: 257 - 279

   

10. A perspective on the past, the present, and the future of computational fluid dynamics (CFD) in flow chemistry

    • Natan Padoin
    • Tatiana Matiazzo
    • Cíntia Soares

    Perspectives 16 February 2024 Pages: 239 - 256

    

11. Practical synthesis of tetrahydrofolate by highly efficient catalytic hydrogenation in continuous flow

    • Heng Pang
    • Junrong Huang
    • Fen-Er Chen

    Full Paper 16 February 2024

    

12. Advances in cofactor immobilization for enhanced continuous-flow biocatalysis

    • Bente Reus
    • Matteo Damian
    • Francesco G. Mutti

    Review Open access 14 February 2024 Pages: 219 - 238

    

13. Continuous and size-control synthesis of lipopolyplex nanoparticles enabled by controlled micromixing performance for mRNA delivery

    • Shirong Song
    • Zhikai Liu
    • Guangwen Chen

    Full Paper 12 February 2024

    

14. Design and implementation of an automated DT-PhotoFluor radiosynthesis module for ¹⁸F-fluorination of aliphatic, branched chain amino acids

    • Gokce Engudar
    • Zheliang Yuan
    • Paul Schaffer

    Full Paper 07 February 2024 Pages: 11 - 21

    

15. A fully continuous-flow process for the synthesis of 4-nitropyrazole

    • Jiadi Zhou
    • Zhaoyang Mu
    • Zhiqun Yu

    Full Paper 31 January 2024

    

16. Investigation into a high-p,T,c continuous flow synthesis of myristyl-γ-picolinium chloride (MGPC) – a preservative in pharmaceutical formulations

    • Karuna Veeramani
    • Manish Shinde
    • Srinivas Oruganti

    Communications 26 January 2024

    

17. The continuous flow synthesis of azos

    • Adam T. McCormack
    • John C. Stephens

    Review Open access 26 January 2024

    

18. An affordable, programmable and interactive continuous flow Photoreactor setup for undergraduate organic synthetic teaching labs

    • Michał Domański
    • Gilles Marcou
    • Joshua P. Barham

    Full Paper Open access 18 January 2024 Pages: 349 - 355

    

19. Continuous flow ozonolysis of cardanol for greener synthesis of bio-based monomers

    • Sphurti P. Kulkarni
    • Amol A. Kulkarni

    Full Paper 18 January 2024

    

20. Continuous flow synthesis of meso-substituted porphyrins with inline UV–Vis analysis

    • Firdaus Parveen
    • Henry J. Morris
    • Anna G. Slater

    Communications Open access 15 January 2024 Pages: 23 - 31

    

21. Solid dosing in High-Throughput Experimentation: generalization of mass enhancer technologies for submilligram scale

    • Taline Kerackian
    • Géraud Chacktas
    • Eugénie Romero

    Communications 09 January 2024 Pages: 367 - 375

    

22. Application of stop-flow micro-tubing reactor system in organic reaction development

    • Qian Wang
    • Ruize Yin
    • Jie Wu

    Review 28 December 2023 Pages: 97 - 107

    

23. Continuous synthesis of ε-caprolactone in a microreactor and kinetics insights into its side reactions

    • Bin Wu
    • Xindi Feng
    • Jing Zhang

    Full Paper 27 December 2023 Pages: 337 - 347

    

24. Flow chemical laboratory practice for undergraduate students: synthesis of paracetamol

    • Bettina Rávai
    • Máté János Orosz
    • Erika Bálint

    Full Paper Open access 27 December 2023

    

25. Continuous synthesis of boron-doped carbon nitride supported silver nanoparticles in an ultrasound-assisted coiled flow inverter microreactor

    • Yu-tian Tao
    • Ke-Jun Wu
    • Chao-Hong He

    Full Paper 22 December 2023 Pages: 177 - 196

    

26. Continuous-flow Synthesis of Anisotropic Plasmonic Nanostructures

    • Vini Singh
    • Perali Ramu Sridhar
    • R. Singh

    Full Paper 18 December 2023

    

27. Two photons are better than one: continuous flow synthesis of ꞵ-lactones through a doubly photochemically-activated Paternò-Büchi reaction

    • Federica Minuto
    • Emanuele Farinini
    • Andrea Basso

    Full Paper Open access 15 December 2023 Pages: 149 - 159

    

28. HO-SAS catalyzed protection and deprotection of aldehydes and alcohols in continuous flow reactors

    • Takahide Fukuyama
    • Toshiaki Hirano
    • Kengo Takamura

    Communications 13 December 2023 Pages: 297 - 301

    

29. Methyl acetate production by reactive distillation using a vertical plate microdistillator

    • Yosuke Muranaka
    • Taisuke Maki
    • Kazuhiro Mae

    Communications 01 December 2023 Pages: 289 - 295

    

30. Telescoped synthesis of vicinal diamines via ring-opening of electrochemically generated aziridines in flow

    • Marharyta Laktsevich-Iskryk
    • Anastasiya Krech
    • Maksim Ošeka

    Communications 29 November 2023 Pages: 139 - 147

    

31. Asymmetric electrochemical synthesis in flow

    • Daniele Mazzarella

    Perspectives Open access 28 November 2023 Pages: 357 - 366

    

32. Impact of gas-solid direct contact on gas-liquid-solid reaction performance in a flow reactor

    • Shusaku Asano
    • Hiroyuki Miyamura
    • Jun-ichiro Hayashi

    Communications 28 November 2023 Pages: 329 - 335

    

33. Enhancing N-arylation productivity: the amplified potential of electrophotocatalysis in flow

    • Jolien De Ketelaere
    • Thomas S. A. Heugebaert

    Full Paper 28 November 2023 Pages: 119 - 128

    

34. Investigations on the continuous flow generation of 2,6-dichloro-N-fluoropyridinium tetrafluoroborate using F₂ gas

    • Kevin Simon
    • Desiree Znidar
    • C. Oliver Kappe

    Communications Open access 28 November 2023 Pages: 427 - 434

    

35. Continuous Flow Generation of Highly Reactive Organometallic Intermediates: A Recent Update

    • Mauro Spennacchio
    • Philipp Natho
    • Marco Colella

    Review 28 November 2023 Pages: 43 - 83

    

36. Nitration process of 2-(2,4-dichlorophenyl)-4-(difluoromethyl)-5-methyl-1,2,4-triazol-3-one in a microreactor

    • Jian-yang Cao
    • Jing Hou
    • Bin-dong Li

    Communications 09 November 2023 Pages: 281 - 288

    

37. Leveraging flow chemistry for the synthesis of trisubstituted isoxazoles

    • Michael Prieschl
    • Niklas Sulzer
    • C. Oliver Kappe

    Full Paper Open access 08 November 2023 Pages: 405 - 411

38. Synthesis of BuNENA in a continuous flow microreactor

    • Zhi-Yuan Jiang
    • Jing Hou
    • Bin-Dong Li

    Communications 07 November 2023 Pages: 449 - 456

    

39. The joint effort of enzyme technology and flow chemistry to bring biocatalytic processes to the next level of sustainability, efficiency and productivity

    • Silvia Donzella
    • Martina Letizia Contente

    Perspectives Open access 07 November 2023 Pages: 85 - 96

    

40. Investigating the photochemical reaction of an oxazolone derivative under continuous-flow conditions: from analytical monitoring to implementation in an advanced UVC-LED-driven microreactor

    • Gaëlle Lebrun
    • Marie Schmitt
    • Karine Loubière

    Full Paper 07 November 2023 Pages: 413 - 425

    

41. Recent developments of automated flow chemistry in pharmaceutical compounds synthesis

    • Jiashu Wu
    • Xingxing Yang
    • Zhiguo Zhang

    ReviewPaper 06 November 2023 Pages: 385 - 404

    

42. Perspectives on flow biocatalysis: the engine propelling enzymatic reactions

    • Ana I. Benítez-Mateos
    • Francesca Paradisi

    Perspectives Open access 23 October 2023 Pages: 211 - 218

    

43. Development of an automated flow chemistry affinity-based purification process for DNA-encoded chemistry

    • Robin Dinter
    • Katharina Götte
    • Norbert Kockmann

    Full Paper Open access 26 September 2023 Pages: 361 - 373

    

44. Droplet generation at T-junctions in parallelized microchannels

    • Zhongdong Wang
    • Xingyu Xiang
    • Taotao Fu

    Full Paper 16 August 2023 Pages: 313 - 327

    

45. Continuous-flow synthesis of 7-methoxy-1-tetralone: an important intermediate of (-)-Dezocine

    • Liangchuan Lai
    • Liang Gao
    • Fener Chen

    Full Paper 27 July 2023 Pages: 375 - 383

    

46. Safe and on-demand protocol for the continuous generation of SO₂ and Cl₂ for subsequent utilization in organic synthesis

    • Gulice Yiu Chung Leung
    • Shannon Thoi Rui Ying
    • Balamurugan Ramalingam

    Full Paper 24 July 2023 Pages: 129 - 138

    

47. Enantioselective catalytic Strecker reaction on cyclic (Z)-aldimines in flow: reaction optimization and sustainability aspects

    • Antonella Ilenia Alfano
    • Andrea Sorato
    • Margherita Brindisi

    Full Paper Open access 19 July 2023 Pages: 197 - 210

    

48. Continuous flow process development for the synthesis of an industrial raw material via solvent-free aromatic Claisen rearrangement

    • Nikola Petrovic
    • Sándor B. Ötvös
    • C. Oliver Kappe

    Communications Open access 14 July 2023 Pages: 443 - 447

    

49. 3D printed reactors and Kessil lamp holders for flow photochemistry: design and system standardization

    • Matthew R. Penny
    • Stephen T. Hilton

    Communications Open access 05 July 2023 Pages: 435 - 442

    

50. Continuous morphology-controllable precipitation strategy for europium oxalate hydrates via microchannel reactor

    • Keyu Tao
    • Hao Li
    • Yefan Li

    Full Paper 30 June 2023 Pages: 347 - 357