Articles

1. Uridine 5′-Diphospho-glucuronosyltransferase 1A3 (UGT1A3) Prediction of Hepatic Clearance of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Substrate Telmisartan by Glucuronidation Using In Vitro–In Vivo Extrapolation (IVIVE)

   • Ewelina Gabor-Worwa
   • Anna Kowal-Chwast
   • Kamil Kus

   Original Research Article 20 April 2024 Pages: 393 - 403

   

2. Long-Acting Strategies for Antibody Drugs: Structural Modification, Controlling Release, and Changing the Administration Route

   • Hao Wang
   • Mengdi Song
   • Kehai Liu

   Review Article 18 April 2024 Pages: 295 - 316

   

3. A Phase I Clinical Study Comparing the Pharmacokinetics, Safety, and Immunogenicity of GB221 Injection and Trastuzumab (Herceptin^®) in Healthy Chinese Adults

   • Yu Zhu
   • Chen Li
   • Yi Fang

   Original Research Article 02 April 2024 Pages: 383 - 392

   

4. Assessment of the Effects of Abrocitinib on the Pharmacokinetics of Probe Substrates of Cytochrome P450 1A2, 2B6 and 2C19 Enzymes and Hormonal Oral Contraceptives in Healthy Individuals

   • Xiaoxing Wang
   • Martin E. Dowty
   • Bimal K. Malhotra

   Original Research Article Open access 30 March 2024 Pages: 367 - 381

   

5. A Phase I, Open-Label, Mass Balance Study of [¹⁴C]-Iberdomide in Healthy Subjects

   • Yiming Cheng
   • Xiaomin Wang
   • Yan Li

   Original Research Article 23 March 2024 Pages: 355 - 365

   

6. Correction: Population Pharmacokinetic Analysis of Vancomycin in Patients with Solid or Hematological Malignancy in Relation to the Quick Sequential Organ Failure Assessment Scores

   • Yasumasa Tsuda
   • Masahiro Takahashi
   • Hirotoshi Echizen

   Correction 18 March 2024 Pages: 405 - 405

7. Kinetic Characterization of Estradiol Glucuronidation by Liver Microsomes and Expressed UGT Enzymes: The Effects of Organic Solvents

   • Caimei Wu
   • Meixue Luo
   • Danyi Lu

   Original Research Article 12 March 2024 Pages: 343 - 353

   

8. Anti-calcitonin Gene-Related Peptide Monoclonal Antibodies in Migraine: Focus on Clinical Pharmacokinetics

   • Slobodan M. Janković
   • Snežana V. Janković

   Review Article 10 March 2024 Pages: 277 - 293

9. Anti-Calcitonin Gene-Related Peptide Monoclonal Antibodies in Migraine: Focus on Drug Interactions

   • Slobodan M. Janković
   • Snežana V. Janković

   Review Article 08 March 2024 Pages: 263 - 275

10. Predicting Pharmacokinetics of Drugs Using Artificial Intelligence Tools: A Systematic Review

    • Mahnaz Ahmadi
    • Bahareh Alizadeh
    • Mahdiye Abiyarghamsari

    Systematic Review 08 March 2024 Pages: 249 - 262

    

11. Safety, Tolerability, and Pharmacokinetics of the Monoamine Oxidase B Inhibitor, HEC122505, and its Major Metabolite After Single- and Multiple- Ascending Dose, and Food Effect Study in Healthy Chinese Subjects

    • Chuanfei Jin
    • Chao Yi
    • Haiping Liang

    Original Research Article 06 March 2024 Pages: 331 - 341

    

12. Pharmacokinetic Study of Ultrasmall Superparamagnetic Iron Oxide Nanoparticles HY-088 in Rats

    • Xin Song
    • Minglan Zheng
    • Yunliang Qiu

    Original Research Article 23 February 2024 Pages: 317 - 330

    

13. Pharmacokinetics, Safety Profile, and Tolerability of Tetramethylpyrazine Nitrone Tablets After Single and Multiple Ascending Doses in Healthy Chinese Volunteers

    • Gangzhi Zhu
    • Liu Wang
    • Xiaoai He

    Original Research Article 21 February 2024 Pages: 207 - 217

    

14. Pharmacokinetics of Dasatinib in Rats: a Potential Food–Drug Interaction with Naringenin

    • Mohammad Raish
    • Ajaz Ahmad
    • Omer Mansour Mohammed

    Original Research Article 20 February 2024 Pages: 239 - 247

    

15. Pharmacokinetic–Pharmacodynamic Modelling in Hemophilia A: Relating Thrombin and Plasmin Generation to Factor VIII Activity After Administration of a VWF/FVIII Concentrate

    • Lars L. F. G. Valke
    • Michael E. Cloesmeijer
    • Waander L. van Heerde

    Original Research Article Open access 17 February 2024 Pages: 191 - 205

    

16. Pharmacokinetics of the Novel Nonsteroidal Mineralocorticoid Receptor Antagonist Ocedurenone (KBP-5074) in Individuals with Moderate Hepatic Impairment

    • James McCabe
    • Jay Zhang
    • Vincent Benn

    Original Research Article Open access 08 February 2024 Pages: 229 - 237

    

17. Influence of Bile Acids on Clindamycin Hydrochloride Skin Permeability: In Vitro and In Silico Preliminary Study

    • Dragana Zaklan
    • Dušan Nešić
    • Nebojša Pavlović

    Original Research Article 08 February 2024 Pages: 219 - 228

    

18. Optimizing Antibiotic Therapy for Intravenous Drug Users: A Narrative Review Unraveling Pharmacokinetics/Pharmacodynamics Challenges

    • Marta Colaneri
    • Camilla Genovese
    • Elena Seminari

    Current Opinion 08 February 2024 Pages: 123 - 129

19. Improved Pharmacokinetic and Pharmacodynamic Profile of Deuterium-Reinforced Tricyclic Antidepressants Doxepin, Dosulepin, and Clomipramine in Animal Models

    • Shreyash Moharir
    • Likhit Akotkar
    • Rajesh Rane

    Original Research Article 03 January 2024 Pages: 181 - 190

    

20. Pharmacokinetic Interaction Between Imatinib and Metformin in Rats

    • Naling Fan
    • Liying Du
    • Xinran Chen

    Original Research Article 23 December 2023 Pages: 171 - 179

    

21. Pharmacokinetics of Long-Acting Methylphenidate: Formulation Differences, Bioequivalence, Interchangeability

    • Mostafa Moharram
    • Tony Kiang

    Systematic Review 21 December 2023 Pages: 149 - 170

    

22. Novel Techniques and Models for Studying the Role of the Gut Microbiota in Drug Metabolism

    • Jianling Tan
    • Bingxuan Fu
    • Ling Ye

    Review Article 21 December 2023 Pages: 131 - 147

    

23. Evaluation of Hydroxychloroquine as a Perpetrator on Cytochrome P450 (CYP) 3A and CYP2D6 Activity with Microdosed Probe Drugs in Healthy Volunteers

    • Felicitas Stoll
    • Antje Blank
    • Walter E. Haefeli

    Original Research Article Open access 20 December 2023 Pages: 101 - 109

    

24. Comparative Pharmacokinetic Study of Rhubarb Anthraquinones in Normal and Nonalcoholic Fatty Liver Disease Rats

    • Fang Zhang
    • Rui Wu
    • Yunxia Li

    Original Research Article 19 December 2023 Pages: 111 - 121

    

25. Development, Physicochemical Characteristics and Pharmacokinetics of a New Sustained-Release Bilayer Tablet Formulation of Tramadol with an Immediate-Release Component for Twice-Daily Administration

    • Naoki Ishitsubo
    • Shinji Oguro
    • Nobuyuki Ishibashi

    Original Research Article Open access 08 December 2023 Pages: 87 - 100

    

26. Mass Balance and Metabolic Pathways of Eliapixant, a P2X3 Receptor Antagonist, in Healthy Male Volunteers

    • Stefanie Reif
    • Marcus-Hillert Schultze-Mosgau
    • Antje Rottmann

    Original Research Article 03 December 2023 Pages: 71 - 85

    

27. Pharmacokinetic Parameters of Recombinant Human Cyclophilin A in Mice

    • Anastasiia Kalinina
    • Elena Grigorieva
    • Ludmila Khromykh

    Original Research Article 01 December 2023 Pages: 57 - 69

    

28. Pharmacokinetics of Imatinib Mesylate and Development of Limited Sampling Strategies for Estimating the Area under the Concentration–Time Curve of Imatinib Mesylate in Palestinian Patients with Chronic Myeloid Leukemia

    • Deema Hilmi Adawi
    • Nadia Ben Fredj
    • Karim Aouam

    Original Research Article 25 November 2023 Pages: 43 - 55

    

29. Ticagrelor Steady-State Trough Concentration in Chinese Patients Undergoing Percutaneous Coronary Intervention

    • ShaoJun Zheng
    • Qiong Jie
    • YuBing Zhu

    Original Research Article 24 November 2023 Pages: 33 - 42

    

30. Pharmacokinetics of 4-Hydroxybenzaldehyde in Normal and Cerebral Ischemia–Reperfusion Injury Rats Based on Microdialysis Technique

    • Chunping Xu
    • Jin Feng
    • Qing Lin

    Original Research Article 24 November 2023 Pages: 23 - 32

    

31. Distribution, Metabolism, and Excretion of Cenobamate in Adult, Fetal, Neonatal, and Lactating Rats

    • Jairam Palamanda
    • Kelli J. Glenn
    • Susan M. Melnick

    Original Research Article 03 November 2023 Pages: 7 - 21

    

32. Acknowledgement to Referees

    ACKNOWLEDGEMENT TO REFEREES 30 October 2023 Pages: 615 - 617

33. Neural Network Models for Predicting Solubility and Metabolism Class of Drugs in the Biopharmaceutics Drug Disposition Classification System (BDDCS)

    • Aryan Ashrafi
    • Kiarash Teimouri
    • Ali Shayanfar

    Original Research Article 21 October 2023 Pages: 1 - 6

    

34. Effect of Verapamil, a P-glycoprotein-1 and Cytochrome P450 3A4 Inhibitor, on Pharmacokinetics and Metabolic Stability of Ripretinib: A Drug–Drug Interaction Study in Rats

    • Shyamala Mudavath
    • Dongamanti Ashok

    Original Research Article 13 October 2023 Pages: 733 - 746

    

35. Pharmacokinetics, Mass Balance and Metabolism of [¹⁴C]HSK21542, a Novel Kappa Opioid Receptor Agonist, in Humans

    • Jin-jie Yuan
    • Yi-cong Bian
    • Li-yan Miao

    Original Research Article 13 October 2023 Pages: 723 - 731

    

36. The Effects of 16-HETE Enantiomers on Hypertrophic Markers in Human Fetal Ventricular Cardiomyocytes, RL-14 Cells

    • Rahmat Hidayat
    • Mahmoud A. El-Ghiaty
    • Ayman O. S. El-Kadi

    Original Research Article 10 October 2023 Pages: 709 - 722

    

37. The Pharmacokinetic Profile of Palovarotene: An Open-Label Phase I Trial Investigating the Effect of Food and Potential for Drug–Drug Interaction in Healthy Participants

    • Rose Marino
    • Louise Dube
    • Kim-Hanh Le Quan Sang

    Original Research Article Open access 07 October 2023 Pages: 691 - 707

    

38. Population Pharmacokinetics of MYL-1402O, a Proposed Biosimilar to Bevacizumab and Reference Product (Avastin^®) in Patients with Non-squamous Non-small Cell Lung Cancer

    • Joel S. Owen
    • Russell J. Rackley
    • Mark A. Socinski

    Original Research Article 04 October 2023 Pages: 675 - 689

    

39. Use of Clearance Concepts to Simulate Impact of Interleukin-6 on Drug Elimination Governed by Cytochromes P450 3A4 and Glomerular Filtration Rate

    • Xiang Chen
    • Guo Yu
    • Guo-Fu Li

    Commentary 04 October 2023 Pages: 619 - 621

40. Pharmacokinetics and Safety of Long-Acting Release Formulations of Pasireotide (SOM230) in a Male Population Who Are Hyperendemic Hepatitis B/C and Chronic Kidney Disease: An Open-Label, Phase I Study

    • Chun-Jui Huang
    • Chieh-Hua Lu
    • Kuang-Chung Shih

    Original Research Article 26 September 2023 Pages: 665 - 674

    

41. Unraveling the Effects of Acute Inflammation on Pharmacokinetics: A Model-Based Analysis Focusing on Renal Glomerular Filtration Rate and Cytochrome P450 3A4-Mediated Metabolism

    • Feiyan Liu
    • Linda B. S. Aulin
    • J. G. Coen van Hasselt

    Original Research Article Open access 15 September 2023 Pages: 623 - 631

    

42. Effect of Moderate Malnutrition on the Pharmacokinetics of Etoposide and Vincristine in Freshly Weaned Rats

    • Megha Garg
    • Khushboo Gandhi
    • Vikram Gota

    Original Research Article 12 September 2023 Pages: 657 - 663

    

43. Population Pharmacokinetic Analysis of Vancomycin in Patients with Solid or Hematological Malignancy in Relation to the Quick Sequential Organ Failure Assessment Scores

    • Yasumasa Tsuda
    • Masahiro Takahashi
    • Hirotoshi Echizen

    Original Research Article 11 September 2023 Pages: 647 - 655

    

44. Comparison of In Vitro Corneal Permeation and In Vivo Ocular Bioavailability in Rabbits of Three Marketed Latanoprost Formulations

    • Laure Chauchat
    • Camille Guerin
    • Jean-Paul Renard

    Original Research Article Open access 08 September 2023 Pages: 633 - 645

    

45. mRNA-Based Nanomedicine: A New Strategy for Treating Infectious Diseases and Beyond

    • Satyendra Prakash

    Review Article 01 September 2023 Pages: 515 - 529

    

46. Application of Allometric Scaling and Salisbury Rule for the Prediction of Antimalarial Drugs for First-in-Pediatric Dose Selection

    • Iftekhar Mahmood

    Original Research Article 11 August 2023 Pages: 587 - 594

47. Evaluating the Pharmacokinetics of Fentanyl in the Brain Extracellular Fluid, Saliva, Urine, and Plasma of Newborns from Transplacental Exposure from Parturient Mothers Dosed with Epidural Fentanyl Utilizing PBPK Modeling

    • Mo’tasem M. Alsmadi

    Original Research Article 10 August 2023 Pages: 567 - 586

    

48. Preclinical Pharmacokinetics and in vitro Metabolism of FHND5071, a Novel Selective RET Kinase Inhibitor

    • Yiran Han
    • Tiantian Wen
    • Yongqiang Zhu

    Original Research Article 02 August 2023 Pages: 595 - 614

    

49. First-in-Human Study of the Safety, Pharmacokinetics, and Pharmacodynamics of MHV370, a Dual Inhibitor of Toll-Like Receptors 7 and 8, in Healthy Adults

    • Tamas Shisha
    • Maximilian G. Posch
    • Peter Gergely

    Original Research Article Open access 02 August 2023 Pages: 553 - 566

    

50. A Quantitative Prediction Method for the Human Pharmacokinetics of Fc-Fusion Proteins

    • Miki Yokoyama
    • Eiko Suzuki
    • Nobuaki Watanabe

    Original Research Article 02 August 2023 Pages: 541 - 552