Model-Informed Clinical Development of 6-Monthly Injection of Paliperidone Palmitate in Patients with Schizophrenia: Dosing Strategies Guided by Population Pharmacokinetic Modeling and Simulation (Part II) Huybrecht T’jollynRaja VenkatasubramanianOliver Ackaert Original Research Article 20 May 2024
Comparative Pharmacokinetic Study of Standard Astaxanthin and its Micellar Formulation in Healthy Male Volunteers Mohamed T. KhayyalMahmoud H. TeaimaDariush Behnam Original Research Article Open access 15 May 2024
Model-Informed Clinical Development of Once-Every-6-Month Injection of Paliperidone Palmitate in Patients with Schizophrenia: A Pharmacometric Bridging Approach (Part I) Huybrecht T’jollynAlberto RussuJuan Jose Perez-Ruixo Original Research Article 15 May 2024
Prediction of the First-Pass Metabolism of a Drug After Oral Intake Based on Structural Parameters and Physicochemical Properties Mir Amir Hossein HosseiniAli Akbar AlizadehAli Shayanfar Original Research Article 11 May 2024
Influence of UGT2B7, UGT1A4 and ABCG2 Polymorphisms on the Pharmacokinetics and Therapeutic Efficacy of Lamotrigine in Patients with Epilepsy Jing YangJinxingyi WangJianghuan Zheng Original Research Article 06 May 2024
Does Sample Size, Sampling Strategy, or Handling of Concentrations Below the Lower Limit of Quantification Matter When Externally Evaluating Population Pharmacokinetic Models? Mehdi El HassaniUwe LiebchenAmélie Marsot Original Research Article 05 May 2024
The Use of Microdosing for In vivo Phenotyping of Cytochrome P450 Enzymes: Where Do We Stand? A Narrative Review Lisa T. van der HeijdenFrans L. OpdamAlwin D. R. Huitema Review Article Open access 30 April 2024
Uridine 5′-Diphospho-glucuronosyltransferase 1A3 (UGT1A3) Prediction of Hepatic Clearance of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Substrate Telmisartan by Glucuronidation Using In Vitro–In Vivo Extrapolation (IVIVE) Ewelina Gabor-WorwaAnna Kowal-ChwastKamil Kus Original Research Article 20 April 2024 Pages: 393 - 403
Long-Acting Strategies for Antibody Drugs: Structural Modification, Controlling Release, and Changing the Administration Route Hao WangMengdi SongKehai Liu Review Article 18 April 2024 Pages: 295 - 316
A Phase I Clinical Study Comparing the Pharmacokinetics, Safety, and Immunogenicity of GB221 Injection and Trastuzumab (Herceptin®) in Healthy Chinese Adults Yu ZhuChen LiYi Fang Original Research Article 02 April 2024 Pages: 383 - 392
Assessment of the Effects of Abrocitinib on the Pharmacokinetics of Probe Substrates of Cytochrome P450 1A2, 2B6 and 2C19 Enzymes and Hormonal Oral Contraceptives in Healthy Individuals Xiaoxing WangMartin E. DowtyBimal K. Malhotra Original Research Article Open access 30 March 2024 Pages: 367 - 381
A Phase I, Open-Label, Mass Balance Study of [14C]-Iberdomide in Healthy Subjects Yiming ChengXiaomin WangYan Li Original Research Article 23 March 2024 Pages: 355 - 365
Correction: Population Pharmacokinetic Analysis of Vancomycin in Patients with Solid or Hematological Malignancy in Relation to the Quick Sequential Organ Failure Assessment Scores Yasumasa TsudaMasahiro TakahashiHirotoshi Echizen Correction 18 March 2024 Pages: 405 - 405
Kinetic Characterization of Estradiol Glucuronidation by Liver Microsomes and Expressed UGT Enzymes: The Effects of Organic Solvents Caimei WuMeixue LuoDanyi Lu Original Research Article 12 March 2024 Pages: 343 - 353
Anti-calcitonin Gene-Related Peptide Monoclonal Antibodies in Migraine: Focus on Clinical Pharmacokinetics Slobodan M. JankovićSnežana V. Janković Review Article 10 March 2024 Pages: 277 - 293
Anti-Calcitonin Gene-Related Peptide Monoclonal Antibodies in Migraine: Focus on Drug Interactions Slobodan M. JankovićSnežana V. Janković Review Article 08 March 2024 Pages: 263 - 275
Predicting Pharmacokinetics of Drugs Using Artificial Intelligence Tools: A Systematic Review Mahnaz AhmadiBahareh AlizadehMahdiye Abiyarghamsari Systematic Review 08 March 2024 Pages: 249 - 262
Safety, Tolerability, and Pharmacokinetics of the Monoamine Oxidase B Inhibitor, HEC122505, and its Major Metabolite After Single- and Multiple- Ascending Dose, and Food Effect Study in Healthy Chinese Subjects Chuanfei JinChao YiHaiping Liang Original Research Article 06 March 2024 Pages: 331 - 341
Pharmacokinetic Study of Ultrasmall Superparamagnetic Iron Oxide Nanoparticles HY-088 in Rats Xin SongMinglan ZhengYunliang Qiu Original Research Article 23 February 2024 Pages: 317 - 330
Pharmacokinetics, Safety Profile, and Tolerability of Tetramethylpyrazine Nitrone Tablets After Single and Multiple Ascending Doses in Healthy Chinese Volunteers Gangzhi ZhuLiu WangXiaoai He Original Research Article 21 February 2024 Pages: 207 - 217
Pharmacokinetics of Dasatinib in Rats: a Potential Food–Drug Interaction with Naringenin Mohammad RaishAjaz AhmadOmer Mansour Mohammed Original Research Article 20 February 2024 Pages: 239 - 247
Pharmacokinetic–Pharmacodynamic Modelling in Hemophilia A: Relating Thrombin and Plasmin Generation to Factor VIII Activity After Administration of a VWF/FVIII Concentrate Lars L. F. G. ValkeMichael E. CloesmeijerWaander L. van Heerde Original Research Article Open access 17 February 2024 Pages: 191 - 205
Pharmacokinetics of the Novel Nonsteroidal Mineralocorticoid Receptor Antagonist Ocedurenone (KBP-5074) in Individuals with Moderate Hepatic Impairment James McCabeJay ZhangVincent Benn Original Research Article Open access 08 February 2024 Pages: 229 - 237
Influence of Bile Acids on Clindamycin Hydrochloride Skin Permeability: In Vitro and In Silico Preliminary Study Dragana ZaklanDušan NešićNebojša Pavlović Original Research Article 08 February 2024 Pages: 219 - 228
Optimizing Antibiotic Therapy for Intravenous Drug Users: A Narrative Review Unraveling Pharmacokinetics/Pharmacodynamics Challenges Marta ColaneriCamilla GenoveseElena Seminari Current Opinion 08 February 2024 Pages: 123 - 129
Improved Pharmacokinetic and Pharmacodynamic Profile of Deuterium-Reinforced Tricyclic Antidepressants Doxepin, Dosulepin, and Clomipramine in Animal Models Shreyash MoharirLikhit AkotkarRajesh Rane Original Research Article 03 January 2024 Pages: 181 - 190
Pharmacokinetic Interaction Between Imatinib and Metformin in Rats Naling FanLiying DuXinran Chen Original Research Article 23 December 2023 Pages: 171 - 179
Pharmacokinetics of Long-Acting Methylphenidate: Formulation Differences, Bioequivalence, Interchangeability Mostafa MoharramTony Kiang Systematic Review 21 December 2023 Pages: 149 - 170
Novel Techniques and Models for Studying the Role of the Gut Microbiota in Drug Metabolism Jianling TanBingxuan FuLing Ye Review Article 21 December 2023 Pages: 131 - 147
Evaluation of Hydroxychloroquine as a Perpetrator on Cytochrome P450 (CYP) 3A and CYP2D6 Activity with Microdosed Probe Drugs in Healthy Volunteers Felicitas StollAntje BlankWalter E. Haefeli Original Research Article Open access 20 December 2023 Pages: 101 - 109
Comparative Pharmacokinetic Study of Rhubarb Anthraquinones in Normal and Nonalcoholic Fatty Liver Disease Rats Fang ZhangRui WuYunxia Li Original Research Article 19 December 2023 Pages: 111 - 121
Development, Physicochemical Characteristics and Pharmacokinetics of a New Sustained-Release Bilayer Tablet Formulation of Tramadol with an Immediate-Release Component for Twice-Daily Administration Naoki IshitsuboShinji OguroNobuyuki Ishibashi Original Research Article Open access 08 December 2023 Pages: 87 - 100
Mass Balance and Metabolic Pathways of Eliapixant, a P2X3 Receptor Antagonist, in Healthy Male Volunteers Stefanie ReifMarcus-Hillert Schultze-MosgauAntje Rottmann Original Research Article 03 December 2023 Pages: 71 - 85
Pharmacokinetic Parameters of Recombinant Human Cyclophilin A in Mice Anastasiia KalininaElena GrigorievaLudmila Khromykh Original Research Article 01 December 2023 Pages: 57 - 69
Pharmacokinetics of Imatinib Mesylate and Development of Limited Sampling Strategies for Estimating the Area under the Concentration–Time Curve of Imatinib Mesylate in Palestinian Patients with Chronic Myeloid Leukemia Deema Hilmi AdawiNadia Ben FredjKarim Aouam Original Research Article 25 November 2023 Pages: 43 - 55
Ticagrelor Steady-State Trough Concentration in Chinese Patients Undergoing Percutaneous Coronary Intervention ShaoJun ZhengQiong JieYuBing Zhu Original Research Article 24 November 2023 Pages: 33 - 42
Pharmacokinetics of 4-Hydroxybenzaldehyde in Normal and Cerebral Ischemia–Reperfusion Injury Rats Based on Microdialysis Technique Chunping XuJin FengQing Lin Original Research Article 24 November 2023 Pages: 23 - 32
Distribution, Metabolism, and Excretion of Cenobamate in Adult, Fetal, Neonatal, and Lactating Rats Jairam PalamandaKelli J. GlennSusan M. Melnick Original Research Article 03 November 2023 Pages: 7 - 21
Neural Network Models for Predicting Solubility and Metabolism Class of Drugs in the Biopharmaceutics Drug Disposition Classification System (BDDCS) Aryan AshrafiKiarash TeimouriAli Shayanfar Original Research Article 21 October 2023 Pages: 1 - 6
Effect of Verapamil, a P-glycoprotein-1 and Cytochrome P450 3A4 Inhibitor, on Pharmacokinetics and Metabolic Stability of Ripretinib: A Drug–Drug Interaction Study in Rats Shyamala MudavathDongamanti Ashok Original Research Article 13 October 2023 Pages: 733 - 746
Pharmacokinetics, Mass Balance and Metabolism of [14C]HSK21542, a Novel Kappa Opioid Receptor Agonist, in Humans Jin-jie YuanYi-cong BianLi-yan Miao Original Research Article 13 October 2023 Pages: 723 - 731
The Effects of 16-HETE Enantiomers on Hypertrophic Markers in Human Fetal Ventricular Cardiomyocytes, RL-14 Cells Rahmat HidayatMahmoud A. El-GhiatyAyman O. S. El-Kadi Original Research Article 10 October 2023 Pages: 709 - 722
The Pharmacokinetic Profile of Palovarotene: An Open-Label Phase I Trial Investigating the Effect of Food and Potential for Drug–Drug Interaction in Healthy Participants Rose MarinoLouise DubeKim-Hanh Le Quan Sang Original Research Article Open access 07 October 2023 Pages: 691 - 707
Population Pharmacokinetics of MYL-1402O, a Proposed Biosimilar to Bevacizumab and Reference Product (Avastin®) in Patients with Non-squamous Non-small Cell Lung Cancer Joel S. OwenRussell J. RackleyMark A. Socinski Original Research Article 04 October 2023 Pages: 675 - 689
Use of Clearance Concepts to Simulate Impact of Interleukin-6 on Drug Elimination Governed by Cytochromes P450 3A4 and Glomerular Filtration Rate Xiang ChenGuo YuGuo-Fu Li Commentary 04 October 2023 Pages: 619 - 621
Pharmacokinetics and Safety of Long-Acting Release Formulations of Pasireotide (SOM230) in a Male Population Who Are Hyperendemic Hepatitis B/C and Chronic Kidney Disease: An Open-Label, Phase I Study Chun-Jui HuangChieh-Hua LuKuang-Chung Shih Original Research Article 26 September 2023 Pages: 665 - 674
Unraveling the Effects of Acute Inflammation on Pharmacokinetics: A Model-Based Analysis Focusing on Renal Glomerular Filtration Rate and Cytochrome P450 3A4-Mediated Metabolism Feiyan LiuLinda B. S. AulinJ. G. Coen van Hasselt Original Research Article Open access 15 September 2023 Pages: 623 - 631
Effect of Moderate Malnutrition on the Pharmacokinetics of Etoposide and Vincristine in Freshly Weaned Rats Megha GargKhushboo GandhiVikram Gota Original Research Article 12 September 2023 Pages: 657 - 663
Population Pharmacokinetic Analysis of Vancomycin in Patients with Solid or Hematological Malignancy in Relation to the Quick Sequential Organ Failure Assessment Scores Yasumasa TsudaMasahiro TakahashiHirotoshi Echizen Original Research Article 11 September 2023 Pages: 647 - 655
