An Interview with a Distinguished Pharmaceutical Scientist: William M. Pardridge, Recipient of the AAPS Meritorious Manuscript Award Legacy Pages: 1651 - 1654
Intestinal Drug Absorption and Metabolism in Cell Cultures: Caco-2 and Beyond Per ArturssonRonald T. Borchardt Commentary Pages: 1655 - 1658
Apoptosis: A New Pharmacodynamic Endpoint Jessie L.-S. AuNeeraj PanchalYuebo Gan ReviewPaper Pages: 1659 - 1671
Promoter and Intronic Sequences of the Human Thiopurine S-Methyltransferase (TPMT) Gene Isolated from a Human Pacl Genomic Library Eugene Y. KrynetskiMichael Y. FessingWilliam E. Evans OriginalPaper Pages: 1672 - 1678
Recombinant Factor VIII SQ- Inactivation Kinetics in Aqueous Solution and the Influence of Disaccharides and Sugar Alcohols Angelica FatourosThomas ÖsterbergMarianne Mikaelsson OriginalPaper Pages: 1679 - 1684
The Stability and Degradation Pathway of Recombinant Human Parathyroid Hormone: Deamidation of Asparaginyl Residue and Peptide Bond Cleavage at Aspartyl and Asparaginyl Residues Yoshiaki NabuchiEri FujiwaraHidetoshi Ushio OriginalPaper Pages: 1685 - 1690
Spectroscopic Characterization of Interactions Between PVP and Indomethacin in Amorphous Molecular Dispersions Lynne S. TaylorGeorge Zografi OriginalPaper Pages: 1691 - 1698
Chromatographic Indexes on Immobilized Artificial Membranes for Local Anesthetics: Relationships with Activity Data on Closed Sodium Channels Francesco BarbatoMaria I. La RotondaFabiana Quaglia OriginalPaper Pages: 1699 - 1705
Analysis of Drug/Plasma Protein Interactions by Means of Asymmetrical Flow Field-Flow Fractionation Maya MadörinPeter van HoogevestHans Leuenberger OriginalPaper Pages: 1706 - 1712
Study of the Complex Between the Contrast Agent lobitridol (Xenetix®) and Elastase (PPE): A Model for Hydrophobic Site Protection in Drug-Protein Interactions Thierry PrangéAlain NeumanDominique Meyer OriginalPaper Pages: 1713 - 1717
Variability in Size Distribution Measurements Obtained Using Multiple Andersen Mark II Cascade Impactors Stephen W. SteinBernard A. Olson OriginalPaper Pages: 1718 - 1725
In Vivo and In Vitro Diclofenac Sodium Evaluation After Rectal Application of Soft Gelatine Capsules Enabling Application Induced Transformation (AIT) into a Semisolid System of Liquid Crystals (SSLC) for Controlled Release Axel SchneeweisChristel C. Müller-Goymann OriginalPaper Pages: 1726 - 1729
Inulin Hydrogels as Carriers for Colonic Drug Targeting: I. Synthesis and Characterization of Methacrylated Inulin and Hydrogel Formation Liesbeth VervoortGuy Van den MooterRenaat Kinget OriginalPaper Pages: 1730 - 1737
Effects of Topical alpha-Substituted Anandamides on Intraocular Pressure in Normotensive Rabbits David W. PateKristiina JärvinenTomi Järvinen OriginalPaper Pages: 1738 - 1743
Prednicarbate Versus Conventional Topical Glucocorticoids: Pharmacodynamic Characterization In Vitro Katharina LangeAnja GyslerMonika Schäfer-Korting OriginalPaper Pages: 1744 - 1749
Studies on Agents with Mixed NO-Dependent Vasodilating and β-Blocking Activities Donatella BoschiAntonella Di StiloAlberto Gasco OriginalPaper Pages: 1750 - 1758
Cellular Delivery of Oligonucleotides by Synthetic Import Peptide Carrier Sujatha DokkaDavid Toledo-VelasquezYon Rojanasakul OriginalPaper Pages: 1759 - 1764
The Effects of Hexetidine (Oraldene™) on the Adherence of Candida Albicans to Human Buccal Epithelial Cells In Vitro and Ex Vivo and on In Vitro Morphogenesis David S. JonesJames G. McGovernSean P. Gorman OriginalPaper Pages: 1765 - 1771
Heparin Absorption Across the Intestine: Effects of Sodium N-[8-(2-Hydroxybenzoyl)Amino]Caprylate in Rat In Situ Intestinal Instillations and in Caco-2 Monolayers David BraydenElizabeth CreedAndrea Leone-Bay OriginalPaper Pages: 1772 - 1779
Rat Jejunal Permeability and Metabolism of μ-Selective Tetrapeptides in Gastrointestinal Fluids from Humans and Rats Eva KrondahlAchim OrzechowskiHans Lennernäs OriginalPaper Pages: 1780 - 1785
Theoretical Calculation and Prediction of Caco-2 Cell Permeability Using MolSurf Parametrization and PLS Statistics Ulf NorinderThomas ÖsterbergPer Artursson OriginalPaper Pages: 1786 - 1791
Improved Prediction of In Vivo Peroral Absorption from In Vitro Intestinal Permeability Using an Internal Standard to Control for Intra- and Inter-Rat Variability Martin E. DowtyCharles R. Dietsch OriginalPaper Pages: 1792 - 1797
lontophoretic Delivery of Apomorphine I: In Vitro Optimization and Validation Ronald van der GeestMeindert DanhofHarry E. Boddé OriginalPaper Pages: 1798 - 1803
lontophoretic Delivery of Apomorphine II: An In Vivo Study in Patients with Parkinson's Disease Ronald van der GeestTeus van LaarMeindert Danhof OriginalPaper Pages: 1804 - 1810
Stereoselective Disposition of Suspensions of Conventional and Wax-matrix Sustained Release Ibuprofen Microspheres in Rats Christianah Moji AdeyeyeFen-Fang Chen OriginalPaper Pages: 1811 - 1816
The Pharmacokinetics and Electroencephalogram Response of Remifentanil Alone and in Combination with Esmolol in the Rat Sam H. HaidarJ. Edward MoretonNatalie D. Eddington OriginalPaper Pages: 1817 - 1823
Metabolism and Pharmacokinetics of Novel Oral Prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in Dogs Jeng-Pyng ShawCathy M. SueokaKenneth C. Cundy OriginalPaper Pages: 1824 - 1829
Oral Delivery of Heparin in Combination with Sodium N-[8-(2-Hydroxybenzoyl)amino]caprylate: Pharmacological Considerations Theresa M. RiveraAndrea Leone-BayRobert A. Baughman Note Pages: 1830 - 1834
Evaluation of Biocoat® Intestinal Epithelium Differentiation Environment (3-Day Cultured Caco-2 Cells) as an Absorption Screening Model with Improved Productivity Saeho ChongSandra A. DandoRichard A. Morrison Note Pages: 1835 - 1837
Freeze-Drying of Poly((2-dimethylamino)ethyl Methacrylate)-Based Gene Delivery Systems Jong-Yuh CherngPetra van de WeteringWim E. Hennink Note Pages: 1838 - 1841