Articles

1. Radioreceptor Assay of Narcotic Analgesics in Serum

   • Joachim Grevel
   • Jeff Thomas
   • Wolfgang Sadée

   OriginalPaper Pages: 209 - 214

2. Pharmacokinetics and Metabolic Fate of Two Nitroxides Potentially Useful as Contrast Agents for Magnetic Resonance Imaging

   • William R. Couet
   • Ulf G. Eriksson
   • Robert C. Brasch

   OriginalPaper Pages: 203 - 209

3. Pyrazolopyrimidine Metabolism in Parasitic Protozoa

   • Buddy Ullman

   ReviewPaper Pages: 194 - 203

4. Extraction of Natural Substances with Dense Gases

   • Egon Stahl
   • Karl Werner Quirin

   ReviewPaper Pages: 189 - 194

5. CONGRESS ANNOUNCEMENTS

   Announcement Pages: 188 - 188

6. Influence of Volume Shift in Equilibrium Dialysis to Estimate Plasma Protein Binding of Drugs

   • Joseph J. H. M. Lohman
   • Piet M. Hooymans
   • Frans W. H. M. Merkus

   Letter Pages: 187 - 188

7. Rapid Aromatic Hydrogen Exchange in the Antimalarial Primaquine

   • James D. McChesney
   • Srinivasin Sarangan

   OriginalPaper Pages: 184 - 186

8. Experimental Combination Chemotherapy with Thymidylate Synthetase and Ribonucleotide Reductase Inhibitors

   • Shu Kobayashi
   • Takao Hoshino
   • Daniel V. Santi

   OriginalPaper Pages: 181 - 183

9. Correction for Volume Shift during Equilibrium Dialysis by Measurement of Protein Concentration

   • Kathleen M. Giacomini
   • Fee Mi Wong
   • Thomas N. Tozer

   OriginalPaper Pages: 179 - 181

10. Rectal Motility and Bioavailability

    • Josef J. Tukker
    • Cornelis J. de Blaey
    • Gerard A. Charbon

    OriginalPaper Pages: 173 - 178

11. Improved Delivery Through Biological Membranes. XVII. A Site-Specific Chemical Delivery System as a Short-Acting Mydriatic Agent

    • Nicholas Bodor
    • Gary Visor

    OriginalPaper Pages: 168 - 173

12. Avoidance of “First-Pass” Elimination of Rectally Administered Propranolol in Relation to the Site of Absorption in Rats

    • Leo G. J. de Leede
    • Albertus G. de Boer
    • Douwe D. Breimer

    OriginalPaper Pages: 164 - 168

13. Stability of Liposomes on Storage: Freeze Dried, Frozen or as an Aqueous Dispersion

    • D. J. A. Crommelin
    • E. M. G. van Bommel

    OriginalPaper Pages: 159 - 163

14. Liquid Crystals in Emulsions, Creams, and Gels Containing Ethoxylated Sterols as Surfactant

    • C. Müller-Goymann

    OriginalPaper Pages: 154 - 158

15. Skin Structure and Metabolism: Relevance to the Design of Cutaneous Therapeutics

    • Daniel A. W. Bucks

    ReviewPaper Pages: 148 - 153

16. Suicidal Destruction of Cytochrome P-450 by Ethynyl Substituted Compounds

    • Ian N. H. White

    ReviewPaper Pages: 141 - 148

17. Lack of Tobramycin Distribution into Saliva

    • Joel E. Houglum
    • Peter J. Cascella
    • Gary B. Edwards

    Letter Pages: 140 - 140

18. Importance of Structural Free Space to the Solvent Power of Water

    • Reinhard Hüttenrauch
    • Petra Zielke
    • Sabine Fricke

    OriginalPaper Pages: 137 - 139

19. Effect of Thyrotropin-Releasing Hormone on Lipoxygenase-Induced Hypotension in the Unanesthetized Guinea Pig

    • Warren E. Lux, Jr
    • Giora Feuerstein
    • Alan I. Faden

    OriginalPaper Pages: 135 - 137

20. Site Specific Rectal Drug Administration in Man with an Osmotic System: Influence on “First-Pass” Elimination of Lidocaine

    • Leo G. J. de Leede
    • Albertus G. de Boer
    • Douwe D. Breimer

    OriginalPaper Pages: 129 - 134

21. Irreversible Binding of Norethisterone to Human Serum Protein Induced by UV-B Light

    • Aad Sedee
    • Gerard Beijersbergen van Henegouwen
    • Gerrit Lodder

    OriginalPaper Pages: 126 - 129

22. Soft Drugs VI. The Application of the Inactive Metabolite Approach for Design of Soft β-Blockers1?2

    • Nicholas Bodor
    • Yasuo Oshiro
    • William Caldwell

    OriginalPaper Pages: 120 - 125

23. An Efficient In Vitro Assay for Acetylcholinesterase Reactivators Using Immobilized Enzyme

    • Andy M. Trammel
    • John E. Simmons
    • Ronald T. Borchardt

    OriginalPaper Pages: 115 - 120

24. Studies on the Mechanism of Fluoropyrimidine Cytotoxicity in L1210 Cells: Correlation with Inhibition of Thymidylate Synthetase but Not with Incorporation into RNA

    • Kathleen D. Danenberg
    • Donna Becker
    • Peter V. Danenberg

    OriginalPaper Pages: 110 - 115

25. Nephelometric Immunoassay for Therapeutic Drug Level Monitoring

    • Takashi Nishikawa

    ReviewPaper Pages: 105 - 109

26. Drug Concentration, Binding, and Effect In Vivo

    • Nicholas H. G. Holford

    ReviewPaper Pages: 102 - 105

27. EDITORIAL

    Editorial Board Pages: 101 - 101

28. Metabolism and Distribution of Primaquine in Monkeys

    • John K. Baker
    • John A. Bedford
    • James D. McChesney

    OriginalPaper Pages: 98 - 100

29. Synthesis of 8-(3-Carboxy-l-methyl-propylammo)-6-methoxyquinoline: A Newly Characterized Primaquine Metabolite

    • James D. McChesney
    • Srinivasan Sarangan

    OriginalPaper Pages: 96 - 98

30. Retinylnitrones: A New Class of Retinoids with Chemopreventive Action

    • Valeria Balogh-Nair
    • Koji Nakanishi

    OriginalPaper Pages: 93 - 95

31. Proton Magnetic Resonance Studies of the Decomposition of 4-Hydroxycyclophosphamide, a Microsomal Metabolite of Cyclophosphamide

    • Edward J. Valente
    • Kenneth K. Chan
    • Kenneth L. Servis

    OriginalPaper Pages: 89 - 92

32. Pharmacokinetic Determinants in the Design and Evaluation of Sustained-Release Dosage Forms

    • Harold Boxenbaum

    OriginalPaper Pages: 82 - 88

33. Pharmacodynamic Measurements of Methyl Nicotinate Percutaneous Absorption

    • Richard H. Guy
    • Ethel Tur
    • Howard I. Maibach

    OriginalPaper Pages: 76 - 81

34. Effect of Uridine on the Metabolism of 5-Fluorouracil in the CD₈F₁ Murine Mammary Carcinoma System

    • Robert C. Sawyer
    • Robert L. Stolfi
    • Daniel S. Martin

    OriginalPaper Pages: 69 - 75

35. The Hypolipidemic Activity of Benzenetricarboxylic Acids in Rodents

    • Iris H. Hall
    • James M. Jr. Chapman
    • Colleen Gilbert

    OriginalPaper Pages: 63 - 68

36. Drug Interactions Through Binding to Cytochrome P 450: The Experience with H₂-Receptor Blocking Agents

    • Ulrich Klotz
    • Ingrid W. Reimann

    ReviewPaper Pages: 59 - 62

37. Pyrrolo(l ,4)benzodiazepine Antitumor Antibiotics: Chemistry, Interaction with DNA, and Biological Implications

    • Laurence H. Hurley
    • David E. Thurston

    ReviewPaper Pages: 52 - 59

38. Research and Publicity

    • Wayne L. Pines

    Commentary Pages: 51 - 51

39. Who Speaks for the Future?

    • Jere E. Goyan

    Commentary Pages: 50 - 50

40. Factors Affecting the Determination of Unbound Carbamazepine Concentrations in Plasma

    • J. J. H. M. Lohman
    • F. W. H. M. Merkus
    • P. M. Hooymans

    Letter Pages: 49 - 49

41. WIN 44,441: A Stereospecific and Long-Acting Narcotic Antagonist

    • Paul L. Wood
    • Carmencita Pilapil
    • Jean W. Richard

    OriginalPaper Pages: 46 - 48

42. High Pressure Liquid Chromatographic Analysis of Metoclopramide in Serum

    • Jordan L. Cohen
    • Gordon H. Jonathan E. Hisayasu
    • Stephen B. Strum

    OriginalPaper Pages: 43 - 45

43. Continuous Measurements of ATP Secretion in Vivo

    • J. Bryan Smith
    • Sandra E. Burke
    • Arthur Freilich

    OriginalPaper Pages: 40 - 43

44. The Analgesic Activity of Neo-Kyotorphin: A Newly Identified Pentapeptide from Bovine Brain.

    • Kiyoshi Fukui
    • Hiro Amano
    • Hiroshi Takagi

    OriginalPaper Pages: 39 - 39

45. Pharmacokinetics of Anthracyclines in Dogs: Evidence for Structure-Related Body Distribution and Reduction to Their Hydroxy Metabolites

    • Marijn J. M. Oosterbaan
    • Rita J. M. Dirks
    • Eppo van der Kleijn

    OriginalPaper Pages: 33 - 38

46. The Hypolipidemic Activity of N-(p-Chlorobenzoyl)-sulfamate in Rodents and its Effect on Lipid Metabolism

    • I. H. Hall
    • S. D. Wyrick
    • A. Dubey

    OriginalPaper Pages: 28 - 32

47. Influence of Bloodflow on the Absorption of Theophylline from the Jejunum of the Rat

    • Norbert Schurgers
    • Cornelis J. de Blaey

    OriginalPaper Pages: 23 - 27

48. New Lipophilic Terbutaline Ester Prodrugs with Long Effect Duration

    • O. A. Torsten Olsson
    • Leif-Å. Svensson

    OriginalPaper Pages: 19 - 23

49. The Potential of Nucleotide Analogs as Inhibitors of Retroviruses and Tumors

    • Roland K. Robins

    ReviewPaper Pages: 11 - 18

50. Controlled Release of Polypeptides and Other Macromolecules

    • Ronald A. Siegel
    • Robert Langer

    ReviewPaper Pages: 2 - 10