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Retinylnitrones: A New Class of Retinoids with Chemopreventive Action

Pharmaceutical Research volume 1, pages 93–95 (1984)Cite this article

Abstract

Retinoids containing a polar nitrone end group have been synthesized. This new class of extensively conjugated, open chain nitrones has been found to be effective in reversing the keratinization in hamster tracheal organ cultures. The highest activity was displayed by the retinylnitrone bearing the least bulky N-alkyl substituent, i. e., methylnitrone 1; its activity level was comparable to that of all-trans retinoic acid.

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Affiliations

  1. Department of Chemistry, Columbia University, New York, N. Y, 10027

    Valeria Balogh-Nair & Koji Nakanishi

Authors
  1. Valeria Balogh-Nair
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  2. Koji Nakanishi
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Balogh-Nair, V., Nakanishi, K. Retinylnitrones: A New Class of Retinoids with Chemopreventive Action. Pharm Res 1, 93–95 (1984). https://doi.org/10.1023/A:1016359532649

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  • DOI: https://doi.org/10.1023/A:1016359532649

Keywords

  • High Activity
  • Retinoic Acid
  • Organ Culture
  • Retinoid
  • Nitrone