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The Analgesic Activity of Neo-Kyotorphin: A Newly Identified Pentapeptide from Bovine Brain.

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Abstract

Analgesic effects of a novel pentapeptide from bovine brain, termed neo-kyotorphin (Thr-Ser-Lys-Tyr-Arg), were determined in mice after intracisternal injection. Neo-kyotorphin showed a dose-dependent analgesia with an ED50 value of 195 nmol/ mouse. This effect was not blocked by naloxone pretreatment.

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Authors and Affiliations

  1. Dept. of Pharmacology, Kagawa Medical School, Mikicho, Kagawa, 761–07, Japan

    Kiyoshi Fukui

  2. Dept. of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Sakoyo-ku, Kyoto, 606, Japan

    Hiroshi Takagi

Authors
  1. Kiyoshi Fukui
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  2. Hiro Amano
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  3. Yoshiaki Kiso
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  4. Kouki Kitagawa
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  5. Hiroshi Takagi
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Fukui, K., Amano, H., Kiso, Y. et al. The Analgesic Activity of Neo-Kyotorphin: A Newly Identified Pentapeptide from Bovine Brain.. Pharm Res 1, 39 (1984). https://doi.org/10.1023/A:1016330726289

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  • DOI: https://doi.org/10.1023/A:1016330726289

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