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The Hypolipidemic Activity of Benzenetricarboxylic Acids in Rodents

Pharmaceutical Research volume 1, pages 63–68 (1984)Cite this article

Abstract

A series of benzenetricarboxylic acids was shown to be potent hypolipidemic agents in rodents. Terephthalic acid proved to be one of the more potent agents, lowering serum cholesterol 42% and serum triglyceride 33 % at 20 mg/kg/day for 16 days. The ability to lower serum lipids by this agent appeared to be due to multiple modes of action: (1) terephthalic acid suppressed the activities both in vivo and in vitro of a number of regulatory enzymes involved in cholesterol, fatty acid, and triglyceride syntheses; (2) the drug inhibited cholesterol absorption from the GI tract by 43 %; and (3) the drug accelerated lipid excretion in the feces leading to a reduction of cholesterol in the tissue. Terephthalic acid was effective in lowering lipids in normal and hyperlipidemic animals and possessed a safe therapeutic index.

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Affiliations

  1. Division of Medicinal Chemistry, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, 27514

    Colleen Gilbert

Authors
  1. Iris H. Hall
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  2. James M. Jr. Chapman
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  3. Colleen Gilbert
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Hall, I.H., Jr. Chapman, J.M. & Gilbert, C. The Hypolipidemic Activity of Benzenetricarboxylic Acids in Rodents. Pharm Res 1, 63–68 (1984). https://doi.org/10.1023/A:1016399213993

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Keywords

  • Cholesterol
  • Triglyceride
  • Cholesterol Absorption
  • Serum Triglyceride
  • Multiple Mode