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WIN 44,441: A Stereospecific and Long-Acting Narcotic Antagonist

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Abstract

The opiate antagonist WIN 44,441–3 is a potent, stereospecific antagonist of mu, delta, and kappa opiate receptors. This antagonist activity is of long duration (> 4 h) with no agonist activity being observed. It therefore appears that WIN 44,441–3 will be a useful long-acting opiate antagonist for in vivo studies.

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  1. Douglas Hospital Research Centre, 6875 LaSalle Blvd, Verdun, Quebec, H4H 1R3, Canada

    Paul L. Wood

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  1. Paul L. Wood
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  2. Carmencita Pilapil
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  3. Mira Thakur
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  4. Jean W. Richard
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Wood, P.L., Pilapil, C., Thakur, M. et al. WIN 44,441: A Stereospecific and Long-Acting Narcotic Antagonist. Pharm Res 1, 46–48 (1984). https://doi.org/10.1023/A:1016386811268

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