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Yeast expression platforms

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Abstract

Yeasts provide attractive expression platforms. They combine ease of genetic manipulations and the option for a simple fermentation design of a microbial organism with the capabilities of an eukaryotic organism to secrete and to modify a protein according to a general eukaryotic scheme. For platform applications, a range of yeast species has been developed during the last decades. We present in the following review a selection of established and newly defined expression systems. The review is concluded by the description of a wide-range vector system that allows the assessment of the selected organisms in parallel for criteria like secretion or appropriate processing and modification in a given case.

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  1. Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung, Corrensstr. 3, 06466, Gatersleben, Germany

    Erik Böer, Gerhard Steinborn & Gotthard Kunze

  2. PharmedArtis GmbH, Forckenbeckstr. 6, 52074, Aachen, Germany

    Gerd Gellissen

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  1. Erik Böer
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  2. Gerhard Steinborn
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  3. Gotthard Kunze
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  4. Gerd Gellissen
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Correspondence to Gotthard Kunze.

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Böer, E., Steinborn, G., Kunze, G. et al. Yeast expression platforms. Appl Microbiol Biotechnol 77, 513–523 (2007). https://doi.org/10.1007/s00253-007-1209-0

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