Abstract
Recent developments in electron microscopy in the field of clinical pathology have illustrated a firmly established role for the electron microscope in the routine of diagnostic pathology. It will not and cannot displace the optical microscope as a diagnostic tool, however, and so light and electron microscopic examinations of biopsy material are complementary. Whereas the light microscope enables us to examine a wide area of the specimen, electron microscopy with its greater resolution adds important details, that facilitate and substantiate the correct differential diagnosis.
Supported by Bundesministerium für Jugend, Familie und Gesundheit Grant No. 341-172/9 and by Deutsche Forschungsgemeinschaft SFB 104
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References
Aparisi T, Arborgh B, Ericsson LE (1977a) Giant cell tumor of bone. Detailed fine structural analysis of different cell components. Virchows Arch (Pathol Anat) 376: 273–298
Aparisi T, Arborgh B, Ericsson LE (1977b) Giant cell tumor of bone. Fine structural localization of acid phosphatase. Virchows Arch (Pathol Anat) 376: 299–308
Aparisi T, Arborgh B, Ericsson LE (1978) Giant cell’ tumor of bone. Fine structural localization of alkaline phosphatase. Virchows Arch (Pathol Anat) 378: 287–295
Ball J, Freedman L, Sissons HA (1977) Malignant round cell tumors of bone: an analytical histological study from the cancer research campaign’s bone tumour panel. Br J Cancer 36: 254–268
Bessis M (1972) Living blood cells and their ultrastructure. Springer, Berlin Heidelberg New York
Cawley JC, Hayhoe FGJ (1972) Ultrastructure of haemic cells. Saunders, London Philadelphia Toronto
Dahlin DC (1978) Bone tumors. General aspects and data on 6221 cases, 3rd edn. Thomas, Springfield, Ill.
Dahlin DC, Unni KK, Matsuno T (1977) Malignant (fibrous) histiocytoma of bone. Fact or fancy? Cancer 39: 1508–1516
Destouet JM, Kyriakos M, Gilula LA (1980) Fibrous histiocytoma (fibroxanthoma) of a cervical vertebra. Skeletal Radiol 5: 241–246
Dominok GW, Eisengarten W (1980) Benignes fibröses Histiocytom des Knochens. Zentralbl Allg Pathol 124: 77–83
Dominok GW, Knoch HG (1977) Knochengeschwülste and geschwulstähnliche Knochenerkrankungen, 2. Aufl. VEB Fischer, Jena
Erlandson RA, Huvos AG (1974) Chondrosarcoma: a light and electron microscopic study. Cancer 34: 1642–1652
Ewing J (1921) Diffuse endothelioma of bone. Proc NY Pathol Soc 24: 17–24
Fawcett DW (1966) On the occurrence of a fibrous lamina on the inner aspect of the nuclear envelope in certain cells of vertebrates. Am J Anat 119: 129–145
Friedman I, Harrison DFN, Bird ES (1962) The fine structure of chordoma with particular reference to the physaliforous cell. J Clin Pathol 15: 116–125
Ghadially FN (1980) Diagnostic electron microscopy of tumours. Butterworths, London Boston
Grundmann E, Roessner A, Immenkamp M (1981) Tumor cell types in osteosarcoma as revealed by electron microscopy — Implications for histogenesis and subclassification. Virchows Arch (Cell Pathol) 36: 257–273
Hanaoka H, Friedman B, Mack RP (1970) Ultrastructure and histogenesis of giant cell tumor of bone. Cancer 25: 1408–1423
Hou-Jensen K, Priori E, Dmochowski L (1972) Studies on the ultrastructure of Ewing’s sarcoma of bone. Cancer 29: 280–286
Huvos AG (1979) Bone tumors. Diagnosis, treatment and prognosis. Saunders, Philadelphia London Toronto
Huvos AG, Marcove RC, Erlandson RA, Mike V (1972) Chondroblastoma of bone. A clinicopathologic and electron microscopic study. Cancer 29: 760–771
Iwashita K (1965) Electron microscopic study on giant cell tumor. J Jpn Orthop Assoc 39: 29–47
Katenkamp D, Stiller D, Waldmann G (1978) Ultrastructural cytology of human osteosarcoma cells. Virchows Arch (Pathol Anat) 381: 49–61
Kay S, Schatzky PF (1972) Ultrastructural observations of a chordoma arising in the clivus. Hum Pathol 3: 403–413
Levine GD, Bensch KG (1972) Chondroblastoma — The nature of the basic cell. A study by means of histochemistry, tissue culture, electron microscopy and auto-radiography. Cancer 29: 1546–1562
Llombart-Bosch A, Olaya AP, Fernandez AL (1974) Non ossifying fibroma of bone. A histochemical and ultrastructural characterization. Virchows Arch (Pathol Anat) 362: 13–21
Llombart-Bosch A, Blache R, Olaya AP (1978) Ultrastructural study of 28 cases of Ewing’s sarcoma: typical and atypical forms. Cancer 41: 1362–1373
Mahony JP, Alexander RW (1978) Ewing’s sarcoma. A light and electron microscopic study of 28 cases. Am J Surg Pathol 2: 283–291
Mikuz G, Mydla F, Glitter W (1977) Chordoma: ultrastructural, biochemical and cytophotometric findings. Beitr Pathol 161: 150–165
Mirra JM (1980) Bone tumors. Diagnosis and treatment. Lippincott, Philadelphia Toronto
Murad TM, Marthy MSN (1970) Ultrastructure of a chordoma. Cancer 25: 1204–1215
Nakayama I, Tauda N, Muta H, Fuiji K, Matsuo T, Takaharo 0 (1975) Fine structural comparison of Ewing’s sarcoma with neuroblastoma. Acta Pathol Jpn 25: 251–268
Oliva H, Navas J, Navarro N, Ferrer M (1974) Histogenesis ultrastructural de un tumor de celulas gigantes recidivantes de hueso. Rev Ortop Traumatol 18: 3–18
Povysil C, Matejovsky Z (1977) Ultrastructure of Ewing’s tumour. Virchows Arch (Pathol Anat) 374: 303–316
Reddick RL, Michelitch HJ, Levine AM, Triche Ti (1980) Osteogenic sarcoma. A study of the ultrastructure. Cancer 45: 64–71
Roessner A, Hobik HP, Immenkamp M, Grundmann E (1979a) Ultrastructure of telangiectatic osteosarcoma. J Cancer Res Clin Oncol 95: 197–207
Roessner A, Hobik HP, Grundmann E (1979b) Malignant fibrous histiocytoma of bone and osteosarcoma. A comparative light and electron microscopic study. Pathol Res Pract 164: 386–403
Roessner A, Immenkamp M, Weidner A, Hobik HP, Grundmann E (1981) Benign fibrous histiocytoma of bone. Light and electron microscopic observations. J Cancer Res Clin Oncol 101: 191–202
Roessner A, Voss B, Rauterberg J, Immenkamp M, Grundmann E (1982) Biological characterization of human bone tumors. I. Ewing’s sarcoma. A comparative electron and immunofluorescence microscopic study. J Cancer Res Clin Oncol (to be published)
Sanerkin NG (1980) The diagnosis and grading of chondrosarcoma of bone. A combined cytologic and histologic approach. Cancer 45: 582–594
Schajowicz F (1959) Ewing’s sarcoma and reticulum cell sarcoma of bone. With special reference to the histochemical demonstration of glycogen as an aid to differential diagnosis. J Bone Joint Surg (Am) 41: 349–356
Schajowicz F (1981) Tumors and tumorlike lesions of bone and joints. Springer, Berlin Heidelberg New York
Schulz A (1980) Ultrastrukturpathologie der Knochentumoren. Fischer, Stuttgart New York
Spanier SS, Enneking WF, Enriquez P (1975) Primary malignant fibrous histiocytoma of bone. Cancer 36: 2084–2098
Steiner GC (1974) Fibrous cortical defect and non ossifying fibroma of bone. A study of the ultrastructure. Arch Pathol 97: 205–210
Steiner GC (1979) Ultrastructure of benign cartilagineous tumors of intraosseous origin. Hum Pathol 10: 71–86
Steiner GC, Kantor EB (1977) Ultrastructure of aneurysmal bone cyst. Cancer 40: 2967–2978
Steiner GC, Ghosh L, Dorfman H (1972) Ultrastructure of giant cell tumor of bone. Hum Pathol 3: 569–586
Takahashi K, Sato T, Kojima M (1976) Cytological characterization and histogenesis of Ewing’s sarcoma. Acta Pathol Jpn 26: 167–190
Themann H (1980) Möglichkeiten and Grenzen der Transmissionselektronenmicroskopie in der Diagnostik. Mikroskopie 36: 274–282
Uehlinger E, Haferkamp 0 (1978) Das maligne fibröse Histiocytom des Knochens. Arch Orthop Trauma Surg 92: 89–97
Wellman KF (1969) Chondroblastoma of the scapula. A case report with ultrastructural observations. Cancer 24: 408–416
Welsh RA, Meyer AT (1964) A histogenetic study of chondroblastoma. Cancer 17: 578–589
Zollinger HU, Mihatsch MJ (1978) Renal pathology in biopsy. Springer, Berlin Heidelberg New York
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Roessner, A., Grundmann, E. (1982). Electron Microscopy in Bone Tumor Diagnosis. In: Berry, C.L. (eds) Bone and Joint Disease. Current Topics in Pathology, vol 71. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68382-4_6
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DOI: https://doi.org/10.1007/978-3-642-68382-4_6
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