Summary
Case report of a patient with an unusual, rapidly growing bone tumor in the third and fourth cervical vertebrae. Histological and electron-microscopic investigations reveal a tumor composed of histiocytic cells, xanthomatous cells, giant cells of Touton type, and fibroblastic cells. No cellular features of malignancy are observed. From its cytologic appearance the tumor has to be classified as a benign fibrous histiocytoma. Regarding its ultrastructural features, the tumor may not be distinguished from non-ossifying fibroma of bone, but its clinical pattern shows obvious differences of localization and growth potential. The term “benign fibrous histiocytoma of bone” is proposed for these tumors which must be differentiated from non-ossifying fibroma.
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References
Auböck L (1975) Zur Ultrastruktur fibröser und histiocytärer Hauttumoren (Dermatofibroma, Dermatofibrosarcoma protuberans, Fibroxanthom und Histiocytom). Virchows Arch A 368:253–274
Destouet JM, Kyriakos M, Gilula LA (1980) Fibrous histiocytoma (fibroxanthoma) of a cervical vertebra. Skeletal Radiol 5:241–246
Dominok GW, Eisengarten W (1980) Benignes fibröses Histiocytom des Knochens. Zentralbl Allg Pathol Pathol Anat 124:77–83
Feldman F, Norman D (1972) Intra- and extraosseous malignant histiocytoma (malignant fibrous xanthoma). Radiology 104:497–508
Fu YS, Gabbiani G, Kaye G, Lattes R (1975) Malignant soft tissue tumors of probable histiocytic origin (malignant fibrous histiocytomas): General considerations and electron-microscopic and tissue cultural studies. Cancer 35:176–198
Huvos GA (1979) Bone Tumors. Diagnosis, Treatment, and Prognosis. Saunders, Philadelphia London Toronto
Llombart-Bosch A, Olaya AP, Fernandez AL (1974) Non-ossifying fibroma of bone. A histochemical and ultrastructural characterization. Virchows Arch [Pathol Anat] 362:13–21
Merkow LP, Frich JC, Slifkin M, Kyreages CG, Pardo M (1971) Ultrastructure of a fibroxanthosarcoma (malignant fibroxanthoma). Cancer 28:372–383
Mirra JM (1980) Bone Tumors. Diagnosis and Treatment. Lippincott, Philadelphia Toronto
Ozello L, Stout AP, Murray MR (1963) Cultural characteristics of malignant histiocytomas and fibrous xanthomas. Cancer 16:331–334
Roessner A, Hobik HP, Grundmann E (1979) Malignant fibrous histiocytoma of bone and osteosarcoma. A comparative light- and electron-microscopic study. Pathol Res Pract 164:385–401
Schulz A (1980) Ultrastrukturpathologie der Knochentumoren. Veröffentlichung aus der Pathologie. Gustav Fischer Verlag, Stuttgart New York
Steiner GC (1974) Fibrous cortical defect and non-ossifying fibroma of bone. A study of the ultrastructure. Arch Pathol 97:205–210
Stout AP, Lattes R (1967) Tumors of the soft tissues. Atlas of tumor pathology, 2nd ser., fasc. I. Armed Forces Institute of Pathology, Washington
Uehlinger E, Haferkamp O (1978) Das maligne fibröse Histiocytom des Knochens. Arch Orthop Traumat Surg 92:89–91
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Roessner, A., Immenkamp, M., Weidner, A. et al. Benign fibrous histiocytoma of bone. J Cancer Res Clin Oncol 101, 191–202 (1981). https://doi.org/10.1007/BF00413313
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DOI: https://doi.org/10.1007/BF00413313