Summary
The microscopic morphology, histochemistry and electron microscopy of a non-ossifying fibroma of the upper metaphysis of the femur in a sixteen-year-old girl, is presented.
The authors describe a fibroblastic cell type as the basis of the neoplasia which transforms itself into a foam cell loaded with lipids. Histochemically it is characterized by high activity in alkaline phosphatases, ATP-ases, fructose 1–6 diphosphatase and NADH-NADPH tetrazolio reductases. Electron microscopy identifies extremely active fibroblastic cells with a synthesis of proteic and lipid material which transforms them into foam cells. The lipids appear irregularly enveloped in laminar systems. There is also a deposit of hemosiderine in certain fibroblasts.
Non-ossifying fibroma differs from the metaphyseal fibrous bone defect as the fibroblasts show a higher activity for alkaline phosphatase and lipids are stored in the cytoplasma.
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Llombart Bosch, A., Peydro Olaya, A. & Lopez Fernandez, A. Non-ossifying fibroma of bone. Virchows Arch. A Path. Anat. and Histol. 362, 13–21 (1974). https://doi.org/10.1007/BF00433771
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DOI: https://doi.org/10.1007/BF00433771