Summary
Recent investigations have shown that telangiectatic osteosarcoma has a poorer prognosis than other osteosarcomas. To elucidate the histogenesis of TOS two cases were investigated on the electron microscopic level. The results show that besides anaplastic, osteoblast-like, and fibroblast-like tumor cells angiosarcomatous components can be observed in this malignant bone tumor, which are characterized by endothelial cells with pinocytotic vesicles, tight intercellular junctions, fine fibrils, and so-called Weibel-Palade bodies in their cytoplasm. From these results, it is concluded that telangiectatic osteosarcoma is derived from multipotent mesenchymal cells with potential differentiation into various directions, such as osteoblast-like cells, endothelial cells, and fibroblast-like cells.
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Roessner, A., Hobik, H.P., Immenkamp, M. et al. Ultrastructure of telangiectatic osteosarcoma. J. Cancer Res. Clin. Oncol. 95, 197–207 (1979). https://doi.org/10.1007/BF00401013
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DOI: https://doi.org/10.1007/BF00401013