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Purinergic Signaling in the Cerebellum

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Handbook of the Cerebellum and Cerebellar Disorders

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Abstract

Purinergic signalling is a highly complex and evolutionarily conserved mechanism of extracellular communication in the brain that is involved in many physiological and pathological functions. The complexity of the system stems from the multitude of purine receptor subtypes and the large number of potential endogenous purine receptor ligands (ATP, ADP, UTP, UDP UDP-glucose, and adenosine) which can either be directly released or arise from extracellular metabolism (and thus are potentially controlled by a variety of metabolizing enzymes). Here we summarize data on the purinergic signalling that occurs in the cerebellum. Although much work has defined purine receptor distribution, the cellular effects of purine receptor activation, how and when purines are released in the cerebellum, little is known on the role of purinergic signalling in cerebellar circuits and the importance of purines in cerebellar motor control.

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Acknowledgments

Work in the author’s laboratory is currently funded by the BBSRC and Epilepsy Research UK. We are grateful for comments on the chapter by Professor Nicholas Dale, Professor Bruno Frenguelli, and Dr. Yuri Pankratov.

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  1. School of Life Sciences, University of Warwick, Coventry, UK

    Mark J. Wall

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  1. Mark J. Wall
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Correspondence to Mark J. Wall .

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Editors and Affiliations

  1. Bruxelles, Belgium

    Mario Manto

  2. Scripps Research Institute Dept. Neuropharmacology, La Jolla, CA, USA

    Donna Gruol

  3. Dept. Neurology, Harvard Medical School Massachusetts General Hospital, Boston, MA, USA

    Jeremy Schmahmann

  4. Gunma University Dept. Integrative Physiology, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  5. Dept Pathology & Immunology & Neuro, Baylor College of Medicine Dept Pathology & Immunology & Neuro, Houston, TX, USA

    Roy Sillitoe

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  1. Molecular and Integrative Neuroscience Department (MIND), The Scripps Research Institute, La Jolla, California, USA

    Donna L. Gruol

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Wall, M.J. (2019). Purinergic Signaling in the Cerebellum. In: Manto, M., Gruol, D., Schmahmann, J., Koibuchi, N., Sillitoe, R. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-97911-3_40-2

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  • DOI: https://doi.org/10.1007/978-3-319-97911-3_40-2

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