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Experimental models

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Clinical Nephrotoxins

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Abstract

In order to test hypothesis and dissect out the mechanisms by which nephrotoxins induce renal injury, it is critical that convenient, reproducible animal models be available. However, given the complexity of the kidney, and because the functional effect of a nephrotoxin can include: vascular, intraluminal, and direct tubular cell effects, no single experimental model is ideally suited to yield all necessary insights. Because of this, a variety of experimental models for the study of nephrotoxicity have been undertaken, including whole animal, isolated perfused kidney, isolated microvessel, isolated proximal tubule, and cultured cells. Each, when appropriately applied and interpreted, produces useful information. However, each technique also has major limitations which must be appreciated when interpreting the results. In this chapter, five commonly used experimental approaches will be briefly reviewed, stressing their utility and shortcomings.

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Authors
  1. Walter Pfaller
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  2. Christian C. Willinger
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  3. Samuel Heyman
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  4. Mayer Brezis
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  5. Seymour Rosen
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  6. John D. Conger
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  7. Richard A. Zager
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Editor information

Editors and Affiliations

  1. Division of Nephrology and Hypertension, University of Antwerp, Belgium

    M. E. De Broe  & G. A. Verpooten  & 

  2. Department of Medicine, The Oregon Health Sciences University, Portland, Oregon, 97201, USA

    G. A. Porter

  3. Division of Nephrology, The Oregon Health Sciences University, Portland, Oregon, 97201, USA

    W. M. Bennett

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Pfaller, W. et al. (1998). Experimental models. In: De Broe, M.E., Porter, G.A., Bennett, W.M., Verpooten, G.A. (eds) Clinical Nephrotoxins. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9088-4_5

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  • DOI: https://doi.org/10.1007/978-94-015-9088-4_5

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