Abstract
Mushrooms including mycorrhizal species are widely appreciated all over the world for their nutritional properties and pharmaceutical value. They are also used as functional food additives (“nutraceuticals” and “nutriceuticals”) owing to the synergistic effects of present bioactive compounds. Medicinal aspects of wild and cultivated edible ectomycorrhizal mushrooms (EEMM), their chemical composition, main groups of bioactive compounds (polysaccharides, flavonoids, phenolic compounds, terpenoids, lectins, etc.) and their health-enhancing therapeutic effects (antitumor, immune-modulating, immune-suppressive, antibacterial, antifungal, antiviral, antiprotozoal, antioxidant, nematicidal, insecticidal, antioxidant, neurotropic, psychotropic), as well as mushroom compounds active against metabolic syndrome and related diseases are discussed. The data available suggests that EEMM can be regarded as valuable natural products to develop healthy functional food supplements and mushroom-based pharmaceuticals that can be used in the prevention and treatment of various diseases. Further research on EEMM biology and the development of new cultivation technologies should aid progress on their biotechnological and medicinal potential.
“Medicines and food have a common origin” Old Chinese saying
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Al-Laith AAA (2010) Antioxidant components and antioxidant/antiradical activities of desert truffle (Tirmania nivea) from various Middle Eastern origins. J Food Compos Anal 23:15–22. doi:10.1016/j.jfca.2009.07.005
Al-Marzooky MA (1981) Truffles in eye disease. In: Proceedings of international conference on Islamic medicine, Kuwait
Anke H, Sterner O (1991) Comparison of the antimicrobial and cytotoxic activities of twenty unsaturated sesquiterpene dialdehydes from plants and mushrooms. Planta Med 57:344–346, http://www.ncbi.nlm.nih.gov/pubmed/1775575. Accessed 22 Apr 2012
Anke H, Bergendorff O, Sterner O (1989) Assays of the biological activities of guaiane sesquiterpenoids isolated from the fruit bodies of edible Lactarius species. Food Chem Toxicol 27:393–397, http://www.ncbi.nlm.nih.gov/pubmed/2792969. Accessed 22 Apr 2012
Anke H, Morales P, Sterner O (1996) Assays of the biological activities of two fatty acid derivatives formed in the edible mushrooms Cantharellus cibarius and C. tubaeformis as a response to injury. Planta Med 62:181–183, http://www.ncbi.nlm.nih.gov/pubmed/8657757. Accessed 22 Apr 2012
Badalyan SM (2000) Antitumor and immune-modulating activities of compounds from several basidiomycete mushrooms. Probl Med Mycol 2:23–28
Badalyan SM (2003) Edible and medicinal higher Basidiomycetes mushrooms, as a source of natural antioxidants. Int J Med Mushrooms 5:153–162. doi:10.1615/InterJMedicMush.v5.i2.40
Badalyan SM (2004) Antiprotozoal activity and mitogenic effect of mycelium of culinary medicinal shiitake mushroom Lentinus edodes (Berk.) Sing (Agaricomycetidae). Int J Med Mushrooms 6:127–134. doi:10.1615/IntJMedMushr.v6.i2.40
Barreira JCM, Barros L, Martins A, Ferreira ICFR (2011) Edible mycorrhizal mushrooms, as sources of bioactive phenolic compounds. In: 1st Iberic meeting on natural bioactives entrapment for the food industry. Challenges and Perspectives, from Nanotechnology to Bioavailability, Lisbon
Barros L, Calhelha RC, Vaz JA, Ferreira ICFR, Baptista P, Estevinho LM (2007) Antimicrobial activity and bioactive compounds of Portuguese wild edible mushrooms methanolic extracts. Eur Food Res Technol 225:151–156. doi:10.1007/s00217-006-0394-x
Bastida J, Viladomat F, Llabres JM, Codina C (1987a) Screening of higher fungi from Catalonia for alkaloids - I. Int J Crude Drug Res 25:120–124
Bastida J, Viladomat F, Llabres JM, Codina C (1987b) Screening of higher fungi from Catalonia for alkaloids - II. Int J Crude Drug Res 25:129–132. doi:10.3109/13880208709060915
Borchers A, Keen CL, Gershwin ME (2004) Mushrooms, tumors, and immunity: an update. Exp Biol Med 229:393–406. doi:10.1007/s11274-010-0545-x
Bovi M, Carrizo ME, Capaldi S, Perduca M, Chiarelli LR, Galliano M, Monaco HL (2011) Structure of a lectin with antitumoral properties in king bolete (Boletus edulis) mushrooms. Glycobiology 21:1000–1009. doi:10.1093/glycob/cwr012
Brandt CR, Piraino F (2000) Mushroom antivirals. Recent Res Dev Antimicrob Agents Chemother 4:11–26
Bresinsky A, Besl H (1990) A colour atlas of poisonous fungi. Wolfe, London
Bross M, Hilger CS, Klamann J-D, Schöneseiffen J, Steglich W, Sterner O (1987) Alkaloids from toadstools and mushrooms. In: Chemistry and biotechnology of biologically active natural products. Proceedings of 4th international conference, Budapest
Butler MS (2004) The role of natural product chemistry in drug discovery. J Nat Prod 67:2141–2153. doi:10.1021/np040106y
Byeon SE, Lee J, Lee E, Lee SY, Hong EK, Kim YE, Cho JY (2009) Functional activation of macrophages, monocytes and splenic lymphocytes by polysaccharide fraction from Tricholoma matsutake. Arch Pharm Res 32:1565–1572. doi:10.1007/s12272-009-2108-y
Casimir J, Jadot J, Renard M (1960) Separation and characterization of N-ethyl-γ-glutamine from Xerocomus badius. Biochim Biophys Acta 39:462–468. doi:10.1016/0006-3002(60)90199-2
Cerigini E, Palma F, Buffalini M, Amicucci A, Ceccaroli P, Saltarelli R, Stocchi V (2007) Identification of a novel lectin from the Ascomycetes fungus Tuber borchii. Int J Med Mushrooms 9:287. doi:10.1615/IntJMedMushr.v9.i34.100
Chang ST (2006) Development of the culinary-medicinal mushrooms industry in China: past, present, and future. Int J Med Mushrooms 8:1–18. doi:10.1615/IntJMedMushr.v8.i1.10
Chang ST, Miles PG (2004) Mushrooms: cultivation, nutritional value, medicinal effect and environmental impact, 2nd edn. CRC, Boca Raton, FL
Chaumont JP, Simeray J (1982) Les propriétés antifongiques des 225 Basidiomycetes et Ascomycetes vis-à-vis des 7 champignons pathogenes cultivés in vitro. Cryptogam Mycol 3:249–259
Chauveau C (1990) Étude des polysaccharides des macromycètes. DEA de Biologie et Technologie Végétales de l’Universite Paul Sabatier, Toulouse
Chellal A, Lukasova E (1995) Evidence for antibiotics in the two Algerian truffles Terfezia and Tirmania. Pharmazie 50:228–229, http://www.ncbi.nlm.nih.gov/pubmed/7732062. Accessed 25 Apr 2012
Cheung LM, Cheung PCK, Ooi VEC (2003) Antioxidant activity and total phenolics of edible mushroom extracts. Food Chem 81:249–255. doi:10.1016/S0308-8146(02)00419-3
Chung S-T (2006) The need for scientific validation of culinary-medicinal mushroom products. Int J Med Mushrooms 8:187–195. doi:10.1615/IntJMedMushr.v8.i2.100
Cieniecka-Rosłonkiewicz A, Sas A, Przybysz E, Morytz B, Syguda A, Pernak J (2007) Ionic liquids for the production of insecticidal and microbicidal extracts of the fungus Cantharellus cibarius. Chem Biodivers 4:2218–2224. doi:10.1002/cbdv.200790179
Darkin-Rattray SJ, Gurnett AM, Myers RW, Dulski PM, Crumley TM, Allocco JJ et al (1996) Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc Natl Acad Sci USA 93:13143–13147, http://www.pnas.org/content/93/23/13143.abstract. Accessed 22 April 2012
Das K (2010) Diversity and conservation of wild mushrooms in Sikkim with special reference to Barsey Rhododendron Sanctuary NeBIO 1:1–13. http://nebio.in/neceer/NEBIO_1_2_AUG_Das.pdf. Accessed 22 Apr 2012
Denisova NP (2001) Traditions of using medicinal mushrooms in different nations. Int J Med Mushrooms 3:409–415. http://www.begellhouse.com/journals/708ae68d64b17c52,4cf0547d63409c36,23c0ed177f7236ff.html. Accessed 22 Apr 2012
Denisova NP (2005) Proteolytic enzymes of Basidiomycetes (taxonomical and ecological aspects). Int J Med Mushrooms 7:395–396. doi:10.1615/IntJMedMushr.v7.i3
Dib-Bellahouel S, Fortas Z (2011) Antibacterial activity of various fractions of ethyl acetate extract from the desert truffle, Tirmania pinoyi, preliminarily analyzed by gas chromatography–mass spectrometry (GC-MS). Afr J Biotechnol 10:9694–9699, http://www.academicjournals.org/ajb/PDF/pdf2011/24Aug/DibBellahouel%20and%20Fortas.pdf. Accessed 22 Apr 2012
Dulger B, Gonuz A, Gucin F (2004) Antimicrobial activity of the macrofungus Cantharellus cibarius. Pak J Biol Sci 7:1535–1539. doi:10.3923/pjbs.2004.1535.1539
Duncan CJG, Pugh N, Pasco DS, Ross SA (2002) Isolation of a galactomannan, that enhances macrophage activation from the edible fungus Morchella esculenta. J Agric Food Chem 50:5683–5685. doi:10.1021/jf020267c
Elmastas M, Isildak O, Turkekul I, Temur N (2007) Determination of antioxidant activity and antioxidant compounds in wild edible mushrooms. J Food Comp Anal 20:337–345. doi:10.1007/s00003-010-0625-8
Ersel FY, Cavas L (2008) Enzyme-based scavengers and lipid peroxidation in some wild edible Agaricales s.l. mushrooms from Mugla. Int J Med Mushrooms 10:269–277. doi:10.16.15/IntJMedMushr.V10.13.80
Ey J, Schömig E, Taubert D (2007) Dietary sources and antioxidant effect of ergothioneine. J Agric Food Chem 55:6466–6474. doi:10.1021/jf071328f
Ferreira ICFR, Baptista P, Vilas-Boas M, Barros L (2007) Free-radical scavenging capacity and reducing power of wild edible mushrooms from Northeast Portugal: individual cap and stipe activity. Food Chem 100:1511–1516. doi:10.1016/j.foodchem.2005.11.043
Ferreira ICFR, Barros L, Abreu RMV (2009) Antioxidants in wild mushrooms. Curr Med Chem 16:1543–1560. doi:10.3390/molecules16064328
Ferreira ICFR, Vaz JA, Vasconcelos MH, Martins A (2010) Compounds from wild mushrooms with antitumor potential. Anticancer Agents Med Chem 10:424–436, http://www.ncbi.nlm.nih.gov/pubmed/20545620. Accessed 22 Apr 2012
Fortas Z, Dib-Belahouel S (2007) Extraction des substances bioactives des terfez d’Algérie et mise en évidence de leur activité antimicrobienne. R Rég Arid 1:280–282, http://cat.inist.fr/?aModele=afficheN%26cpsidt=20030638. Accessed 22 Apr 2012
Francia C, Rapior S, Courtecuisse R, Siroux Y (1999) Current research findings on the effects of selected mushrooms on cardiovascular diseases. Int J Med Mushrooms 1:169–172
Fujimoto H, Nakayama Y, Yamazaki M (1993) Identification of immunosuppressive components of a mushroom, Lactarius flavidulus. Chem Pharm Bull 41:654–658. doi:10.1248/cpb.41.654
Geraci C, Piattelli M, Tringali C, Verbist J-F, Roussakis C (1992) Cytotoxic activity of tetraprenylphenols related to suillin, an antitumor principle from Suillus granulatus. J Nat Prod 55:1772–1775. doi:10.1021/np50090a010
Guo T, Wei L, Sun J, Ch-lin H, Fan l (2011) Antioxidant activities of extract and fractions from Tuber indicum Cooke & Massee. Food Chem 127:1634–1640. doi:10.1016/j.foodchem.2011.02.030
Guzman G (2001) Hallucinogenic, medicinal, and edible mushrooms in Mexico and Guatemala: traditions, myths, and knowledge. Int J Med Mushrooms 3:399–408, http://www.begellhouse.com/journals/708ae68d64b17c52,4cf0547d63409c36,3434ff1753328d31.html. Accessed 24 Apr 2012
Guzman G (2008) Diversity and use of traditional Mexican medicinal fungi. A review. Int J Med Mushrooms 10:209–217. doi:10.1615/IntJMedMushr.v10.i3
Hackman W, Meinander M (1979) Diptera feeding as larvae on macrofungi in Finland. Ann Zool Fenn 16:50–83, http://sciaroidea.info/node/23487. Accessed 25 Apr 2012
Hannan MA, Al-Dakan AA, Aboul-Enein HY, Al-Othaimeen AA (1989) Mutagenic and antimutagenic factor(s) extracted from a desert mushroom using different solvents. Mutagenesis 4:111–114. doi:10.1093/mutage/4.2.111
Hawksworth DL (2001) Mushrooms: the extent of the unexplored potential. Int J Med Mushrooms 3:333–337, http://www.begellhouse.com/journals/708ae68d64b17c52,4cf0547d63409c36,503a72d82b669af6.html. Accessed 22 Apr 2012
Hayashi T, Kanetoshi A, Ikura M, Shirhama H (1989) Bolegrevilol, a new lipid peroxidation inhibitor from the edible mushroom Suillus grevillei. Chem Pharm Bull 37:1424–1425. doi:10.1248/cpb.37.1424
Hobbs CR (1995) Medicinal mushrooms: an exploration of tradition, healing and culture, 2nd edn. Botanical, Santa Cruz, CA
Hoshi H, Iijima H, Ishihara Y, Yasuhara T, Matsunaga K (2008) Absorption and tissue distribution of an immunomodulatory α-d-glucan after oral administration of Tricholoma matsutake. J Agric Food Chem 56:7715–7720. doi:10.1021/jf801123k
Ishihara Y, Iijima H, Yagi Y, Hoshi H, Matsunaga K (2004) Inhibition of decrease in natural killer cell activity in repeatedly restraint-stressed mice by a biological response modifier derived from cultured mycelia of the Basidiomycete Tricholoma matsutake. Neuroimmunomodulation 11:41–48. doi:10.1159/000072968
Janakat S, Al-Fakhiri S, Sallal A-K (2004) A promising peptide antibiotic from Terfezia claveryi aqueous extract against Staphylococcus aureus in vitro. Phytother Res 18:810–813. doi:10.1002/ptr.1563
Janakat SM, Al-Fakhiri SM, Sallal AK (2005) Evaluation of antibacterial activity of aqueous and methanolic extracts of the truffle Terfezia claveryi against Pseudomonas aeruginosa. Saudi Med J 26:952–955, http://www.ncbi.nlm.nih.gov/pubmed/15983681. Accessed 22 Apr 2012
Jonassohn M (1996) Sesquiterpenoid unsaturated dialdehydes: structural properties that affect reactivity and bioactivity. Lund University, Sweden
Kandefer-Szersen M, Kawecki Z, Salata B, Witek M (1980) Mushrooms as a source of substances with antiviral activity. Acta Mycol 16:215–220
Kokean Y, Nishii T, Furuichi Y (2002) Effects of Hatakeshimeji (Lyophyllum decastes Sing.) diet on blood pressure in spontaneously hypertensive rats. Nippon Sokuhin Kagaku Kogaku Kaishi 49:126–129, http://sciencelinks.jp/j-east/article/200206/000020020602A0246970.php. Accessed 22 Apr 2012
Konska G (2006) Lectins of higher fungi (Macromycetes) - their occurrence, physiological role, and biological activity. Int J Med Mushrooms 8:19–30. doi:10.1615/IntJMedMushr.v8.i1.20
Kukina T, Gorbunova I, Bayandina I (2005) Mushrooms as a source of polyprenols. Int J Med Mushrooms 7:425. doi:10.1615/IntJMedMushr.v7.i3
Lee SJ, Yeo WH, Yun BS, Yoo ID (1999) Isolation and sequence analysis of new peptaibol, boletusin, from Boletus spp. J Peptide Sci 5:374–378. doi:10.1002/(SICI)1099-1387(199908)5:8<374::AID-PSC211>3.0.CO;2-X
Li J, Li P, Liu F (2008) Production of theanine by Xerocomus badius (mushroom) using submerged fermentation. LWT Food Sci Technol 41:883–889. doi:10.1016/j.lwt.2007.05.020
Li D, Zhao W-H, Kong B-H, Ye M, Chen H-R (2009) Inhibition effects of the extract and polysaccharide in macrofungus on TMV. J Yunnan Agric Univ 24:175–180. doi:10.3852/mycologia.986.971
Lindequist U, Niedermeyer THJ, Julich W-D (2005) The pharmacological potential of mushrooms. eCAM 2:285–299. doi:10.1093/ecam/neh107
Liu F, Ooi VEC, Liu WK, Chang ST (1996) Immunomodulation and antitumor activity of polysaccharide-peptide complex from the culture filtrates of a local edible mushroom, Tricholoma lobayense. Gen Pharmacol 27:621–624. doi:10.1007/s10267-010-0101-4
Lovy A, Knowles B, Labbe R, Nolan L (2000) Activity of edible mushrooms against the growth of human T4 leukemia cancer cells, and Plasmodium falciparum. J Herbs Spices Med Plants 6:49–57. doi:10.1300/J044v06n04_06
Mandeel QA, Al-Laith AAA (2007) Ethnomycological aspects of the desert truffle among native Bahraini and non-Bahraini peoples of the Kingdom of Bahrain. J Ethnopharmacol 110:118–129. doi:10.1016/j.jep.2006.09.014
Miles PG, Chang ST (1997) Mushroom biology: concise basics and current developments. World Scientific, Singapore
Miura T, Kubo M, Itoh Y, Iwamoto N, Kato M, Park SR, Ukawa Y, Kita Y, Suzuki I (2002) Antidiabetic activity of Lyophyllum decastes in genetically type 2 diabetic mice. Biol Pharm Bull Sci Res 25:1234–1237, http://www.ncbi.nlm.nih.gov/pubmed/12230127. Accessed 22 Apr 2012
Mizuno T (1999) The extraction and development of antitumor active polysaccharides from medicinal mushrooms in Japan. Review. Int J Med Mushrooms 1:9–30
Mizuno T, Saito H, Nishitoba T, Kawagishi H (1995) Antitumor active substances from mushrooms. Food Rev Int 111:23–61. doi:10.1080/87559129509541018
Mizuno T, Yeohlui P, Kinoshita T, Zhuang C, Ito H, Mayuzumi Y (1996) Antitumor activity and chemical modification of polysaccharides from Niohshimeji mushroom, Tricholoma giganteum. Biosci Biotechnol Biochem 60:30–33, http://www.ncbi.nlm.nih.gov/pubmed/8824822. Accessed 22 Apr 2012
Moldavan MG, Grodzynska GA, Wasser SP, Storozhuk VM (2001) Effects of some higher Basidiomycetes extracts on the neurons activity. Ukrayins'kyi Botanichnyi Zhurnal 58:220–228
Moradali MF, Mostafavi H, Ghods S, Hedjaroude G-A (2007) Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi). Int Immunopharmacol 7:701–724. doi:10.1016/j.intimp.2007.01.008
Murcia MA, Martinez-Tome M, Jimenez AM, Vera AM, Honrubia M, Parras P (2002) Antioxidant activity of edible fungi (truffles and mushrooms): losses during industrial processing. J Food Prot 65:1614–1622, http://www.ncbi.nlm.nih.gov/pubmed/12380748. Accessed 22 Apr 2012
Ohtsuka S, Ueno S, Yoshikumi C, Hirose F, Ohmura Y, Wada T, Fujii T, Takahashi E (1973) Polysaccharides having an anticarcinogenic effect and a method of producing them from species of basidiomycetes. UK Patent 1331513, 26 Sep 1973
Ooi VE, Liu F (2000) Immunomodulation and anticancer activity of polysaccharide-protein complexes. Curr Med Chem 7:715–729. doi:10.2174/0929867003374705
Palacios I, Lozano M, Moro C, D’Arrigo M, Rostagno MA, Martínez JA, García-Lafuente A, Guillamón E, Villares A (2011) Antioxidant properties of phenolic compounds occurring in edible mushrooms. Food Chem 128:674–678. doi:10.1016/j.foodchem.2011.03.085
Pan SM, Ye JS (1997) Screening of SOD activity from edible and medicinal fungi. J Chin Agric Chem Soc 35:209–219
Pang Z, Sterner O, Anke H (1992) (8e)-10-hydroxydec-8-enoic acid: its isolation from injured fruit bodies of Cantharellus tubaeformis and synthetic preparation. Acta Chem Scand 46:301–302, http://serials.cib.unibo.it/cgi-ser/start/it/spogli/df-s.tcl?prog_art=4259363%26language=ITALIANO%26view=articoli. Accessed 25 Apr 2012
Pemberton RT (1994) Agglutinins (lectins) from British higher fungi. Mycol Res 98:277–290, http://cat.inist.fr/?aModele=afficheN%26cpsidt=4071643. Accessed 25 April 2012
Percudani R, Montanini B, Ottonello S (2005) The anti-HIV cyanovirin-N domain is evolutionarily conserved and occurs as a protein module in eukaryotes. Proteins 60:670–678. doi:10.1002/prot.20543
Piraino FF (2006) Emerging antiviral drugs from medicinal mushrooms. Int J Med Mushrooms 8:101–114. doi:10.1615/IntJMedMushr.v8.i2.20
Poucheret P, Fons F, Rapior S (2006) Biological and pharmacological activity of higher fungi: 20-year retrospective analysis. Cryptogam Mycol 27:311–333. doi:10.3892/ijo_00000122
Pushpa H, Purushothama KB (2010) Nutritional analysis of wild and cultivated edible medicinal mushrooms. World J Dairy Food Sci 5:140–144, http://idosi.org/wjdfs/wjdfs5%282%29/7.pdf. Accessed 22 Apr 2012
Queirós B, Barreira JCM, Sarmento AC, Ferreira ICFR (2009) In search of synergistic effects in antioxidant capacity of combined edible mushrooms. Int J Food Sci Nutr 60:160–172. doi:10.1080/09637480903153845
Reaven G, Ho H, Hofman B (1988) Attenuation of fructose induced hypertension in rats by exercise training. Hypertension 12:129–132. doi:10.1161/01.HYP.12.2.129
Reis FS, Heleno SA, Barros L, Sousa MJ, Martins A, Santos-Buelga C, Ferreira ICFR (2011a) Bioactive and chemical properties of edible mycorrhizal mushrooms from Northeast Portugal. In: VI International workshop on edible mycorrhizal mushrooms (IWEMM6), Rabat
Reis FS, Heleno SA, Barros L, Sousa MJ, Martins A, Santos-Buelga C, Ferreira ICFR (2011b) Toward the antioxidant and chemical characterization of mycorrhizal mushrooms from Northeast Portugal. J Food Sci 76:824–830. doi:10.1111/j.1750-3841.2011.02251.x
Ribeiro B, Lopesa R, Andradea PB, Seabraa RM, Gonçalvesa BP, Quelhasa I, Valentão P (2008) Comparative study of phytochemicals and antioxidant potential of wild edible mushroom caps and stipes. Food Chem 110:47–56. doi:10.1016/j.foodchem.2008.01.054
Rougieux R (1963) Antibiotic and stimulating actions of the desert truffle (Terfezia boudieri Chatin). Ann Inst Pasteur 105:315–318, http://www.ncbi.nlm.nih.gov/pubmed/14048721. Accessed 22 Apr 2012
Roussakis C, Gratas C, Audouin AF, Boterff JL, Dabouis C et al (1991) Study of in vitro drug sensitivity on a newly established cell line from a primary bronchial epidermoid carcinoma of human origin (NSCLCN6). Anticancer Res 11:2239–2244, http://www.ncbi.nlm.nih.gov/pubmed/1776865. Accessed 22 Apr 2012
Seeger R (1980) Studies on rubescenslysin haemolysis. Arch Pharmacol 311:95–104. doi:10.1007/BF00500309
Seeger R, Wiedman R (1972) Zum vorkommen von Hämolysinen und Agglutininen in Höheren Pilzen (Basidiomyceten). Arch Toxikol 29:189–217, http://rd.springer.com/article/ 10.1007/BF00315599. Accessed 22 Apr 2012
Shirata K, Kato T, Niwano M (1995) Selective suppression of the mitogenic response of murine lymphocytes by suillin from Suillus bovines. Mycologia 87:360–361, http://serials.cib.unibo.it/cgi-ser/start/it/spogli/df-s.tcl?prog_art=2933280%26language=ITALIANO%26view=articoli. Accessed 25 Apr 2012
Stenglich W (1981) Biologically active compounds from higher fungi. Pure Appl Chem 53:1233–1240, http://www.iupac.org/publications/pac/1981/pdf/5306x1233.pdf. Accessed 22 Apr 2012
Sterner O (1995) Toxic terpenoids from higher fungi and their possible role in chemical defense systems. Cryptogam Mycol 16:47–57, http://serials.cib.unibo.it/cgi-ser/start/en/spogli/df-s.tcl?prog_art=2637459%26view=articoli. Accessed 25 Apr 2012
Štrukelj B, Kac J, Janeš D, Kristl J, Mlinarič A, Doljak B, Pohleven F, Kreft S (2007) Medicinal mushrooms and drug discovery: identification of potent inhibitors of thrombin, of pancreatic lipase, and novel antibiotic and antigenotoxic compounds. Int J Med Mushrooms 9:195. doi:10.1615/IntJMedMushr.v9.i34.20
Suzuki I, Tanamachi M, Tomida M, Gu Y, Ukawa Y (2001) Antihypertensive effect of Lyophyllum decastes Sing. in spontaneously hypertensive rats. Int J Med Mushrooms 3:229. http://www.begellhouse.com/journals/708ae68d64b17c52,2e5fc0e3182d70db,25a8ed577bc9d749.html. Accessed 22 Apr 2012
Takahashi A, Kusano G, Ohta T, Nozoe S (1988) The constituents of Lactarius flavidulus Imai. Chem Pharm Bull 36:2366–2370. doi:10.1248/cpb.36.2366
Takahashi A, Nunozawa T, Endo T, Nozoe S (1992) Isolation of 1-β-d-arabinofuranosylcytosine from the mushroom Xerocomus nigromaculatus Hongo. Chem Pharm Bull 40:1313–1314. doi:10.1248/cpb.40.1313
Takahashi A, Kusano G, Ohta T, Nozoe S (1993) Revised structures of flavidulols, constituents of Lactarius flavidulus Imai, and the structure of flavidulol-D. Chem Pharm Bull 41:2032–2033. doi:10.1248/cpb.41.2032
Tang W, Lu XC (1999) Study of the biological activity and the antitumor activity against sarcoma-180 of Boletus edulis. J South-West China Normal Univ (Nat Sci) 24:478–481. doi:CNKI:SUN:XNZK.0.1999-04-018
Tardif A (2000) La mycothérapie ou les propriétés médicinales des champignons. Le Courrier du Livre, Paris
Tringali C, Geraci C, Nicolosi G, Verbist JF, Roussakis C (1989a) An antitumor principle from Suillus granulatus. J Nat Prod 52:844–845. doi:10.1021/np50064a030
Tringali C, Piattelli M, Geraci C, Nicolosi G (1989b) Antimicrobial tetraprenylphenols from Suillus granulatus. J Nat Prod 52:941–947. doi:10.1021/np50065a005
Tsai SY, Tsai HL, Mau JL (2007) Antioxidant properties of Agaricus blazei, Agrocybe cylindracea, and Boletus edulis. LWT Food Sci Technol 40:1392–1402. doi:10.1016/j.lwt.2006.10.001
Tsukamoto S, Macabalang AG, Nakatani K, Obara Y, Nakahata N, Ohta T (2003) Tricholomalides A-C, new neurotrophic diterpenes from the mushroom Tricholoma sp. J Nat Prod 66:1578–1581. doi:10.1021/np030140x
Tsvetkova I, Naydenski H, Petrova A (2006) Antibacterial activity of some Bulgarian higher Basidiomycetes mushrooms. Int J Med Mushrooms 8:63–66. doi:10.1615/IntJMedMushr.v8.i1.80
Ukawa Y, Ito H, Hisamatsu M (2000) Antitumor effects of (1→3)-beta-d-glucan and (1→6)-beta-d-glucan purified from newly cultivated mushroom, Hatakeshimeji (Lyophyllum decastes Sing). J Biosci Bioneg 90:98–104. doi:10.1016/S1389-1723(00)80041-9
Ukawa Y, Andou M, Furuichi Y, Kokean Y, Nishii T, Hiasamatsu M (2001a) Hypocholesterolemic activity of Hatakeshimeji (Lyophyllum decastes Sing.) mushroom in rats. Nippon Sokuhin Kagaku Kogaku Kaishi 48:520–525
Ukawa Y, Andou M, Furuichi Y, Kokean Y, Nishii T, Hiasamatsu M (2001b) Angiotensin I-converting enzyme inhibitory and antitumor activity of Hatakeshimeji (Lyophyllum decastes Sing.). Nippon Sokuhin Kagaku Kogaku Kaishi 48:58–63
Ukawa Y, Furuichi Y, Kokean Y, Nishii T, Hisamatsu M (2002) Effect of Hatakeshimeji (Lyophyllum decastes Sing) mushroom on serum lipid levels in rats. J Nutr Sci Vitaminol 48:73–76. doi:10.3177/jnsv.48.73
Ulziijargal E, Mau J-L (2011) Nutrient compositions of culinary-medicinal mushroom fruiting bodies and mycelia. Int J Med Mushrooms 13:343–349. doi:10.1615/IntJMedMushr.v13.i4.40
Vidović SS, Mujić IO, Zeković ZP, Lepojević ZD, Tumbas VT, Mujić AI (2010) Antioxidant properties of selected Boletus mushrooms. Food Biophys 5:49–58. doi:10.1007/s11483-009-9143-6
Villares A, García-Lafuente A, Guillamón E, Ramos Á (2012) Identification and quantification of ergosterol and phenolic compounds occurring in Tuber spp. Truffles J Food Compos Anal. doi:10.1016/j.jfca.2011.12.003
Wang S, Marcone MF (2011) The biochemistry and biological properties of the world’s most expensive underground edible mushroom: Truffles. Food Res Int 44:2567–2581. doi:10.1016/j.foodres.2011.06.008
Wang HX, Ng TB, Ooi VEC, Liu WK, Chanf ST (1996a) A polysaccharide-peptide complex from culture mycelia of the mushroom Tricholoma mongolicum with immunoenhancing and antitumor activities. Biochem Cell Biol 74:95–100. doi:10.1139/o96-010
Wang HX, Ooi VEC, Ng TR, Chiu KW, Chang ST (1996b) Hypotensive and vasorelaxing activities of a lectin from the edible mushroom Tricholoma mongolicum. Pharmacol Toxicol 79:318–323. doi:10.1111/j.1600-0773.1996.tb00016.x
Wang HX, Ng TB, Ooi VEC, Liu WK, Chang ST (1997) Actions of lectins from the mushroom Tricholoma mongolicum on macrophages, splenocystes, and life-span in sarcoma bearing mice. Anticancer Res 17:419–424, http://www.ncbi.nlm.nih.gov/pubmed?term=PMID%3A%209066687. Accessed 22 Apr 2012
Wang HX, Ng TB, Ooi VEC (1998) Lectins from mushrooms – a review. Mycol Res 102:897–906. doi:10.1017/S0953756298006200
Wang M, Triguéros V, Paquereau L, Chavant L, Fournier D (2002a) Proteins as active compounds involved in insecticidal activity of mushroom fruit bodies. J Econ Entomol 95:603–607. doi:10.1603/0022-0493-95.3.603
Wang YX, Bunchanan P, Hall IR (2002b) A list of edible ectomycorrhizal mushrooms. Edible mycorrhizal mushrooms and their cultivation. In: Proceedings of 2nd international conference on edible mycorrhizal mushrooms, Christchurch, New Zealand
Wang J, Wang HX, Ng TB (2007) A peptide with HIV-1 reverse transcriptase inhibitory activity from the medicinal mushroom Russula paludosa. Peptides 28:560–565. doi:10.1016/j.peptides.2006.10.004
Wasser SP (2002) Medicinal mushrooms, as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol 60:256–274. doi:10.1007/s00253-002-1076-7
Wasser SP (2010) Medicinal mushroom science: history, current status, future trends, and unsolved problems. Int J Med Mushrooms 12:1–16. doi:10.1615/IntJMedMushr.v12.i1.10
Wasser SP, Weis AL (1999) Medicinal properties of substances occurring in higher Basidiomycetes mushrooms: current perspectives. Int J Med Mushrooms 1:31–62
Wegiel J, Konska G, Guillot J, Muszynska B, Bohatier J, Kohlmunzer S (2001) Isolation and antimitotic activity of polysaccharides from fruit bodies of Xerocomus badius (Fr.) Kuhn. ex Gilib. Acta Biol Cracov Bot 43:59–64, http://psjc.icm.edu.pl/psjc/cgi-bin/getdoc.cgi?AAAA0029105. Accessed 22 Apr 2012
Witkowska AM, Zujko ME, Mironczuk-Chodakowska I (2011) Comparative study of wild edible mushrooms as sources of antioxidants. Int J Med Mushrooms 13:335–341. doi:10.1615/IntJMedMushr.v13.i4.30
Yang JH, Lin HC, Mau JL (2002) Antioxidant properties of several commercial mushrooms. Food Chem 77:229–235. doi:10.1016/S0308-8146(01)00342-9
Ying J, Mao X, Ma Q, Zong Z, Wen H (1987) Icons of medicinal fungi from China. Science, Beijing
Zaidman B, Yassin M, Mahajana J, Wasser SP (2005) Medicinal mushrooms modulators of molecular targets as cancer therapeutics. Appl Microbiol Biotechnol 67:453–468. doi:10.1007/s00253-004-1787-z
Zhang M, Cui SW, Cheung PCK, Wang Q (2007) Antitumor polysaccharides from mushrooms: a review on their isolation process, structural characteristics and antitumor activity. Trend Food Sci Technol 18:4–19. doi:10.1016/j.tifs.2006.07.013
Zhao S, Zhao Y, Li S, Zhao J, Zhang G, Wang H, Ng TB (2010) A novel lectin with highly potent antiproliferative and HIV-1 reverse transcriptase inhibitory activities from the edible wild mushroom Russula delica. Glycoconjugate J 27:259–265. doi:10.1007/s10719-009-9274-5
Zheng S, Li C, Ng TB, Wang HX (2007) A lectin with mitogenic activity from the edible wild mushroom Boletus edulis. Process Biochem 42:1620–1624. doi:10.1016/j.procbio.2007.09.004
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Badalyan, S. (2012). Medicinal Aspects of Edible Ectomycorrhizal Mushrooms. In: Zambonelli, A., Bonito, G. (eds) Edible Ectomycorrhizal Mushrooms. Soil Biology, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-33823-6_18
Download citation
DOI: https://doi.org/10.1007/978-3-642-33823-6_18
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-33822-9
Online ISBN: 978-3-642-33823-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)