Table of contents

  1. Front Matter
    Pages i-xii
  2. From Molecular Mechanism to Intervention for Congenital Heart Diseases, Now and the Future

    1. Front Matter
      Pages 1-2
    2. Adriana C. Gittenberger-de Groot, E. M. Winter, M. J. Goumans, M. M. Bartelings, R. E. Poelmann
      Pages 11-18 Open Access
    3. Hidekazu Sekine, Tatsuya Shimizu, Teruo Okano
      Pages 19-24 Open Access
    4. Shugo Tohyama, Keiichi Fukuda
      Pages 25-31 Open Access
    5. Roger R. Markwald, Shibnath Ghatak, Suniti Misra, Ricardo A. Moreno-Rodríguez, Yukiko Sugi, Russell A. Norris
      Pages 33-45 Open Access
  3. Left-Right Axis and Heterotaxy Syndrome

    1. Front Matter
      Pages 47-48
    2. Isao Shiraishi
      Pages 49-56 Open Access
    3. Nikolai Klena, George Gabriel, Xiaoqin Liu, Hisato Yagi, You Li, Yu Chen et al.
      Pages 67-79 Open Access
    4. Akimichi Shibata, Keiko Uchida, Jun Maeda, Hiroyuki Yamagishi
      Pages 81-82 Open Access
  4. Cardiomyocyte and Myocardial Development

    1. Front Matter
      Pages 83-84
    2. Kenta Yashiro, Ken Suzuki
      Pages 85-91 Open Access
    3. Shalini A. Muralidhar, Hesham A. Sadek
      Pages 93-101 Open Access
    4. Guillermo Luxán, Gaetano D’Amato, José Luis de la Pompa
      Pages 103-114 Open Access
    5. Robert E. Poelmann, Bjarke Jensen, Margot M. Bartelings, Michael K. Richardson, Adriana C. Gittenberger-de Groot
      Pages 115-123 Open Access
    6. Hajime Fukui, Shigetomo Fukuhara, Naoki Mochizuki
      Pages 125-126 Open Access
    7. Yoshimi Hiraumi, Chengqun Huang, Allen M. Andres, Ying Xiong, Jennifer Ramil, Roberta A. Gottlieb
      Pages 127-128 Open Access
    8. Kazuhiro Maeda, Sachiko Miyagawa-Tomita, Toshio Nakanishi
      Pages 129-130 Open Access

About this book


This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration.   This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.


Cellular Interaction Congenital Heart Disease iPS cells Gene functions Growth factors Transcription factors Cellular interactions Cardiac morphogenesis Cardiac morphology Vascular development

Editors and affiliations

  • Toshio Nakanishi
    • 1
  • Roger R. Markwald
    • 2
  • H.Scott Baldwin
    • 3
  • Bradley B. Keller
    • 4
  • Deepak Srivastava
    • 5
  • Hiroyuki Yamagishi
    • 6
  1. 1.Department of Pediatric CardiologyTokyo Women's Medical UniversityTokyoJapan
  2. 2.Cardiovascular Developmental Biology CenterMedical University of South Carolina Clemson UniversityCharlestonUSA
  3. 3.Department of Pediatrics (Cardiology)Vanderbilt UniversityNashvilleUSA
  4. 4.Pediatrics, Pharmacology and Toxicology, and BioengineeringUniversity of LouisvilleLouisvilleUSA
  5. 5.Gladstone Institute of Cardiovascular DiseaseSan FranciscoUSA
  6. 6.Pediatrics, Division of Pediatric CardiologyKeio University School of MedicineTokyoJapan

Bibliographic information

  • DOI
  • Copyright Information The Editor(s) (if applicable) and the Author(s) 2016
  • Publisher Name Springer, Tokyo
  • eBook Packages Medicine
  • Print ISBN 978-4-431-54627-6
  • Online ISBN 978-4-431-54628-3
  • Buy this book on publisher's site