Skip to main content
  • Book
  • Open Access
  • © 2016

Etiology and Morphogenesis of Congenital Heart Disease

From Gene Function and Cellular Interaction to Morphology

  • Focuses on the etiology and morphogenesis of congenital heart disease

  • Includes contributions by an international group of distinguished scientists and clinicians

  • Highlights the latest research topics and techniques and includes chapters dedicated to clinical implications and future directions

  • Includes supplementary material: sn.pub/extras

Buy it now

Buying options

Softcover Book USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 59.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Table of contents (55 chapters)

  1. Front Matter

    Pages i-xii
  2. From Molecular Mechanism to Intervention for Congenital Heart Diseases, Now and the Future

    1. Front Matter

      Pages 1-2
    2. The Arterial Epicardium: A Developmental Approach to Cardiac Disease and Repair

      • Adriana C. Gittenberger-de Groot, E. M. Winter, M. J. Goumans, M. M. Bartelings, R. E. Poelmann
      Pages 11-18Open Access
    3. Cell Sheet Tissue Engineering for Heart Failure

      • Hidekazu Sekine, Tatsuya Shimizu, Teruo Okano
      Pages 19-24Open Access
    4. Future Treatment of Heart Failure Using Human iPSC-Derived Cardiomyocytes

      • Shugo Tohyama, Keiichi Fukuda
      Pages 25-31Open Access
    5. Congenital Heart Disease: In Search of Remedial Etiologies

      • Roger R. Markwald, Shibnath Ghatak, Suniti Misra, Ricardo A. Moreno-Rodríguez, Yukiko Sugi, Russell A. Norris
      Pages 33-45Open Access
  3. Left-Right Axis and Heterotaxy Syndrome

    1. Front Matter

      Pages 47-48
    2. Left-Right Asymmetry and Human Heterotaxy Syndrome

      • Isao Shiraishi
      Pages 49-56Open Access
    3. Role of Cilia and Left-Right Patterning in Congenital Heart Disease

      • Nikolai Klena, George Gabriel, Xiaoqin Liu, Hisato Yagi, You Li, Yu Chen et al.
      Pages 67-79Open Access
    4. Pulmonary Arterial Hypertension in Patients with Heterotaxy/Polysplenia Syndrome

      • Akimichi Shibata, Keiko Uchida, Jun Maeda, Hiroyuki Yamagishi
      Pages 81-82Open Access
  4. Cardiomyocyte and Myocardial Development

    1. Front Matter

      Pages 83-84
    2. Single-Cell Expression Analyses of Embryonic Cardiac Progenitor Cells

      • Kenta Yashiro, Ken Suzuki
      Pages 85-91Open Access
    3. Meis1 Regulates Postnatal Cardiomyocyte Cell Cycle Arrest

      • Shalini A. Muralidhar, Hesham A. Sadek
      Pages 93-101Open Access
    4. Intercellular Signaling in Cardiac Development and Disease: The NOTCH pathway

      • Guillermo Luxán, Gaetano D’Amato, José Luis de la Pompa
      Pages 103-114Open Access
    5. The Epicardium in Ventricular Septation During Evolution and Development

      • Robert E. Poelmann, Bjarke Jensen, Margot M. Bartelings, Michael K. Richardson, Adriana C. Gittenberger-de Groot
      Pages 115-123Open Access
    6. S1P-S1p2 Signaling in Cardiac Precursor Cells Migration

      • Hajime Fukui, Shigetomo Fukuhara, Naoki Mochizuki
      Pages 125-126Open Access
    7. Myogenic Progenitor Cell Differentiation Is Dependent on Modulation of Mitochondrial Biogenesis through Autophagy

      • Yoshimi Hiraumi, Chengqun Huang, Allen M. Andres, Ying Xiong, Jennifer Ramil, Roberta A. Gottlieb
      Pages 127-128Open Access
    8. The Role of the Thyroid in the Developing Heart

      • Kazuhiro Maeda, Sachiko Miyagawa-Tomita, Toshio Nakanishi
      Pages 129-130Open Access

About this book

This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration.   This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.


Keywords

  • Cellular Interaction
  • Congenital Heart Disease
  • iPS cells
  • Gene functions
  • Growth factors
  • Transcription factors
  • Cellular interactions
  • Cardiac morphogenesis
  • Cardiac morphology
  • Vascular development

Editors and Affiliations

  • Department of Pediatric Cardiology, Tokyo Women's Medical University, Tokyo, Japan

    Toshio Nakanishi

  • Cardiovascular Developmental Biology Center, Medical University of South Carolina Clemson University, Charleston, USA

    Roger R. Markwald

  • Department of Pediatrics (Cardiology), Vanderbilt University, Nashville, USA

    H.Scott Baldwin

  • Pediatrics, Pharmacology and Toxicology, and Bioengineering, University of Louisville, Louisville, USA

    Bradley B. Keller

  • Gladstone Institute of Cardiovascular Disease, San Francisco, USA

    Deepak Srivastava

  • Pediatrics, Division of Pediatric Cardiology, Keio University School of Medicine, Tokyo, Japan

    Hiroyuki Yamagishi

Bibliographic Information

  • Book Title: Etiology and Morphogenesis of Congenital Heart Disease

  • Book Subtitle: From Gene Function and Cellular Interaction to Morphology

  • Editors: Toshio Nakanishi, Roger R. Markwald, H.Scott Baldwin, Bradley B. Keller, Deepak Srivastava, Hiroyuki Yamagishi

  • DOI: https://doi.org/10.1007/978-4-431-54628-3

  • Publisher: Springer Tokyo

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and the Author(s) 2016

  • License: CC BY-NC

  • Hardcover ISBN: 978-4-431-54627-6Published: 05 July 2016

  • Softcover ISBN: 978-4-431-56633-5Published: 07 June 2018

  • eBook ISBN: 978-4-431-54628-3Published: 24 June 2016

  • Edition Number: 1

  • Number of Pages: XII, 383

  • Number of Illustrations: 14 b/w illustrations, 95 illustrations in colour

  • Topics: Cardiology, Pediatric Surgery, Embryology, Pediatrics

Buy it now

Buying options

Softcover Book USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 59.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access