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  • Open Access
  • © 2022

Water-filtered Infrared A (wIRA) Irradiation

From Research to Clinical Settings


  • This book is open access, which means that you have free and unlimited access

  • First comprehensive review of all scientifically based applications of water-filtered Infrared-A irradiation

  • Aiming to enhance communication and advance the use of heat therapy for patient benefit

  • Presenting a wide range of applications in clinical practice

Buying options

Softcover Book USD 49.99
Price excludes VAT (USA)
Hardcover Book USD 59.99
Price excludes VAT (USA)

Table of contents (24 chapters)

  1. Front Matter

    Pages i-xxv
  2. Principles

    1. Front Matter

      Pages 1-1
    2. Glossary Used in wIRA-Hyperthermia

      • H. Piazena, W. Müller, Peter Vaupel
      Pages 3-15Open Access
    3. From Sun to Therapeutic wIRA

      • W. Müller, H. Piazena, Peter Vaupel
      Pages 17-33Open Access
    4. Physical and Photobiological Basics of wIRA-Hyperthermia

      • H. Piazena, W. Müller, Peter Vaupel
      Pages 35-53Open Access
    5. Thermography and Thermometry in wIRA-Hyperthermia

      • W. Müller, H. Piazena, A. R. Thomsen, Peter Vaupel
      Pages 55-67Open Access
    6. Temperature Profiles and Oxygenation Status in Human Skin and Subcutis Upon Thermography-Controlled wIRA-Hyperthermia

      • A. R. Thomsen, M. R. Saalmann, N. H. Nicolay, A. L. Grosu, Peter Vaupel
      Pages 69-80Open Access
  3. Clinical Practice: Oncology

    1. Front Matter

      Pages 81-81
    2. Combined Use of wIRA and Microwave or Radiofrequency Hyperthermia

      • J. Crezee, A. Bakker, R. Zweije, M. W. Kolff, H. J. G. D. van den Bongard, G. van Tienhoven et al.
      Pages 97-106Open Access
    3. Gold Nanoparticles and Infrared Heating: Use of wIRA Irradiation

      • J. F. Hainfeld, H. M. Smilowitz
      Pages 117-127Open Access
  4. Clinical Practice: Psychiatry

    1. Front Matter

      Pages 141-141
    2. Whole-Body Hyperthermia (WBH) in Psychiatry

      • A. Knobel, K. Hanusch, N. Auen, F. Rübener, S. Fischer, C. Borzim et al.
      Pages 155-164Open Access
  5. Clinical Practice: Neonatology

    1. Front Matter

      Pages 165-165
  6. Clinical Practice: Dermatology

    1. Front Matter

      Pages 179-179
    2. Water-Filtered Infrared A Irradiation in Wound Treatment

      • U. Lange, I. Aykara, P. Klemm
      Pages 181-188Open Access

About this book

The aim of this open access book is to provide a unique, timely, critical and comprehensive compilation of more than 30 years of robust international experimental and clinical research related to the basic science and therapeutic application of water-filtered infrared-A (wIRA) and hyperthermia in oncology, psychiatry (depression), musculoskeletal disorders, dermatology, infectiology, and surgery. This is an internationally absolutely unique attempt which publication is timely and of great interest in medical as well as in natural sciences. 

The aim is to enhance communication and advance the use of heat therapy for patient benefit, and to generate an environment in which anyone with an interest in hyperthermia can discuss, collaborate, network, and share events and resources. Productive dialogue and discussion among scientists and practitioners on issues relating to hyperthermia therapy is essential, especially relating to thermal transmission by water-filtered infrared-A (wIRA). The specificity and advantage of this technology is its tolerance by tissue, and its penetration of up to 3 cm allows the delivery of high heat dosages that are relevant across multiple clinical indications. 

Currently, wIRA is being applied in Austria, Germany, Portugal, Switzerland, The Netherlands, UK and the USA. The authors’ hope is that its use will increase in these countries, and also expand into others. 

This book will be an invaluable tool for oncologists, surgeons, dermatologists as well as physiotherapists.


  • Open Access
  • Hyperthermia therapies in practise and experiment
  • Hyperthermia in Oncology
  • Hyperthermia in Physiotherapy
  • Whole body hyperthermia
  • Hyperthermia in Wound-Healing

Editors and Affiliations

  • Department of Radiation Oncology, University Medical Center, University of Freiburg, Freiburg/Breisgau, Germany

    Peter Vaupel

About the editor

Professor Peter Vaupel studied Medicine at the University of Mainz and was awarded the degree of M.D. in 1968 and the degree of Dr. med. in 1969. Thereafter, he underwent training in surgery, internal medicine, obstetrics and gynaecology, and following military service he returned to academic life at the Institute of Physiology, University of Mainz, as a research assistant. His interests turned to the microenvironment of solid tumors. This new area of research proved to be so fascinating and compulsive for Dr. Vaupel that it has kept him occupied for over 30 years! Initially, Dr. Vaupel carried out theoretical and experimental studies on oxygenation and metabolites in tissue-isolated tumors, for which he was awarded the degree of Dr. med. habil. In 1974. Following promotions to Assistant Professor (1972) and Associate Professor (1975), Dr. Vaupel was appointed Full Professor of Physiology in 1977 and became Head of the Department of Applied Physiology at the University of Mainz in 1984. In 1987 he left Mainz to take up the newly established Andrew Werk Cook Professorship of Radiation Biology/Physiology at Harvard Medical School. In 1989 Dr. Vaupel assumed the position as Professor and Chairman of the Department of Pathophysiology at the Institute of Physiology and Pathophysiology at the Johannes Gutenberg-University of Mainz. Since 1998, Professor Vaupel has been a Full Member of the Academy of Science and Literature at Mainz. Dr. Vaupel has managed to dedicate a great deal at effort to the teaching of physiology, as documented by five standard textbooks of Physiology and Pathophysiology. He serves in an advisory capacity to many national and international science foundations and is currently a member of several professional societies, serves on the editorial boards of numerous professional journals and has edited a series of monographs addressing topics in tumor pathophysiology. Over the past 33 years, Dr. Vaupel has published more than 360 well-cited articles and made approximately 560 scientific presentations in which a wide range of therapeutically relevant pathophysiological parameters have been examined. Over the last 25 years, a major focus of Dr. Vaupel’s research has been on the effects of hyperthermia, and much of this research has concentrated on the reciprocal influence of microenvironmental parameters and hyperthermia. With these studies he has made a considerable contribution to our current knowledge of the pathophysiological behaviour of solid tumors upon localized heat treatment and the impact of the special tumor pathophysiology on treatment outcome. In cooperation with Dr. Debra Kelleher, ongoing research is focusing on the development of new treatment modalities such as simultaneously applied combination of localized hyperthermia and photodynamic therapy.

Bibliographic Information

  • Book Title: Water-filtered Infrared A (wIRA) Irradiation

  • Book Subtitle: From Research to Clinical Settings

  • Editors: Peter Vaupel

  • DOI:

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s) 2022

  • License: CC BY

  • Hardcover ISBN: 978-3-030-92879-7Published: 06 May 2022

  • Softcover ISBN: 978-3-030-92882-7Published: 06 May 2022

  • eBook ISBN: 978-3-030-92880-3Published: 05 May 2022

  • Edition Number: 1

  • Number of Pages: XXV, 292

  • Number of Illustrations: 6 b/w illustrations, 111 illustrations in colour

  • Topics: Oncology, Surgery, Dermatology, Physiotherapy

Buying options

Softcover Book USD 49.99
Price excludes VAT (USA)
Hardcover Book USD 59.99
Price excludes VAT (USA)