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Change in Plasma Total, Esterified and Non-esterified Capric Acid Concentrations during a Short-term Oral Administration of Synthetic Tricaprin in Dogs

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Abstract

We studied change in the plasma total, esterified and non-esterified capric acid (FA10:0) and its effect on longer fatty acid concentrations during the short-term oral administration of synthetic tricaprin in dogs. We administered 150 and 1500 mg tricaprin/kg body weight per day orally to dogs for 7 consecutive days. Blood samples were collected at 0, 0.5, 1, 2, 4, 8, and 24 h on the 1st and 7th days for measuring the total-, esterified- and non-esterified-FA10:0. The total-FA10:0 concentration increased in a dose-dependent manner, reaching a peak at 1 h on the 1st day and at 2 to 4 h on the 7th day; it then mostly disappeared within 24 h. The mean esterified FA10:0 concentration was found be 75.5 and 60.3% of total- FA10:0 in dogs fed 150 and 1500 mg of tricaprin/kg body weight, respectively. The plasma level of FA10:0 depends on the duration and dose of tricaprin administration, but are rapidly cleared from circulation within several hours.

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Acknowledgments

This study was financially supported by Research Grant for Rare and Intractable Disease from the Ministry of Health, Labor, and Welfare of Japan, partially supported by a Grant-in-Aid for Scientific Research from the Japan Society for Promotion of Sciences, Japan and partly by the Regional Innovation Strategy Support Program, Sapporo Health Innovation “Smart-H”, of The Ministry of Education, Culture, Sports, Sciences and Technology, Japan.

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Authors and Affiliations

  1. Faculty of Health Sciences, Hokkaido University, Sapporo, 060-0812, Japan

    Rojeet Shrestha, Yusuke Miura, Hitoshi Chiba & Shu-Ping Hui

  2. Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University, Osaka, 565-0874, Japan

    Ken-ichi Hirano, Akira Suzuki & Satoshi Yamaguchi

  3. Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Osaka, 565-0874, Japan

    Ken-ichi Hirano

  4. Laboratory of Advance Data Science, Information Initiative Center, Hokkaido University, Sapporo, 060-0811, Japan

    Yi-Fan Chen & Masahiro Mizuta

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  1. Rojeet Shrestha
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Correspondence to Shu-Ping Hui.

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Shrestha, R., Hirano, Ki., Suzuki, A. et al. Change in Plasma Total, Esterified and Non-esterified Capric Acid Concentrations during a Short-term Oral Administration of Synthetic Tricaprin in Dogs. ANAL. SCI. 33, 1297–1303 (2017). https://doi.org/10.2116/analsci.33.1297

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