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Lymphatic absorption of structured glycerolipids containing medium-chain fatty acids and linoleic acid, and their effect on cholesterol absorption in rats

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Lipids

Abstract

The effects of various structured triglycerides containing medium-chain (caprylic or capric acids) and long-chain (linoleic acid) fatty acids on fatty acid and cholesterol absorption were studied in lymph-cannulated rats. A considerable portion of capric and caprylic acid was absorbed through the lymph duct, although to a lesser extent than was linoleic acid. Capric and linoleic acid located at the 2-position of 2-decanoyl-1,3-dilinoleoyl-glycerol (18∶2/10∶0/18∶2) and 2-linoleoyl-1,3-didecanoyl-glycerol (10∶0/18∶2/10∶0), respectively, tended to be absorbed more efficiently than those located at the 1- and 3-position or those from tricaprin (10∶0/10∶0/10∶0) or trilinolein (18∶2/18∶2/18∶2). A similar trend was observed when the medium-chain fatty acid was caprylic acid instead of capric acid. Caprylic acid absorption from 2-octanoyl-1,3-dilinoleoylglycerol (18∶2/8∶0/18∶2) was significantly greater (p<0.05) than from 2-linoleoyl-1,3-dioctanoyl-glycerol (8∶0/18∶2/8∶0) or tricaprylin (8∶0/8∶0/8∶0). Preferential absorption of caprylic and linoleic acid was not observed when the 1 to 2 and the 2 to 1 mixtures of 8∶0/8∶0/8∶0 and 18∶2/18∶2/18∶2, respectively, were administered. The structured lipids did not affect the lymphatic absorption of cholesterol. The results suggest that structured triglycerides composed of medium-chain fatty acids and linoleic acid may be more useful for the treatment of lipid malabsorption than are mixtures of medium-chain triglyceride (MCT) and long-chain triglycride (LCT).

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Abbreviations

18∶2/10∶0/18∶2:

2-decanoyl-1,3-dilinoleoyl-glycerol

10∶0/18∶2/10∶0:

2-linoleoyl-1,3-didecanoyl-glycerol

8∶0/18∶2/8∶0:

2-linoleoyl-1,3-dioctanoyl-glycerol

EDTA:

ethylenediaminetetraacetic acid

HPLC:

high-performance liquid chromatography

LCT:

long-chain triglyceride

MCT:

medium-chain triglyceride

TLC:

thinlayer chromatography

18∶2/8∶0/18∶2:

2-octanoyl-1,3-dilinoleoylglycerol

10∶0/10∶0/10∶0:

1,2,3-tridecanoyl-glycerol (tricaprin)

18∶2/18∶2/18∶2:

1,2,3-trilinoleoyl-glycerol (trilinolein)

8∶0/8∶0/8∶0:

1,2,3-trioctanoyl-glycerol (tricaprylin)

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Authors and Affiliations

  1. Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture, 46-09, Hakozaki, 812, Fukuoka

    Ikuo Ikeda, Yoshiaki Tomari & Michihiro Sugano

  2. Nisshin Oil Mills Co., 103, Nihonbashi, Tokyo, Japan

    Soichiro Watanabe & Junichi Nagata

Authors
  1. Ikuo Ikeda
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  2. Yoshiaki Tomari
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  3. Michihiro Sugano
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  4. Soichiro Watanabe
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  5. Junichi Nagata
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Ikeda, I., Tomari, Y., Sugano, M. et al. Lymphatic absorption of structured glycerolipids containing medium-chain fatty acids and linoleic acid, and their effect on cholesterol absorption in rats. Lipids 26, 369–373 (1991). https://doi.org/10.1007/BF02537201

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  • DOI: https://doi.org/10.1007/BF02537201

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