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Effect of medium-chain fatty acid positional distribution in dietary triacylglycerol on lymphatic lipid transport and chylomicron composition in rats

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Lipids

Abstract

The present study was carried out to examine if the positional distribution of medium-chain fatty acid (MCF) in dietary synthetic fat influences lymphatic transport of dietary fat and the chemical composition of chylomicrons in rats with permanent cannulation of thoracic duct. Four types of synthetic triacylglycerol were prepared: (i) sn-1(3) MCF-sn 2 linoleic acid, (ii) interesterified sn-1(3) MCF-sn 2 linoleic acid, (iii) sn-2 MCF-sn-1(3) linoleic acid, and (iv) interesterified sn-2 MCF-sn-1(3) linoleic acid. A purified diet composed of equal amounts of the synthetic fat and cocoa butter was given to rats with permanent lymph duct cannulation. The positional distribution of MCF in the dietary fat had no significant effect on the lymph flow, triacylglycerol output, phospholipid output, lipid composition of chylomicrons, or the particle size. The positional distribution of MCF in the synthetic triacylglycerol was maintained in the chylomicron triacylglycerol. These results showed that MCF in the dietary triacylglycerol is transported into lymphatics and the positional distribution is well preserved in chylomicron triacylglycerol.

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Abbreviations

MCF:

medium-chain fatty acids

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Authors and Affiliations

  1. Laboratory of Nutrition Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University, 812-8581, Fukuoka, Japan

    Octavio Carvajal, Masahiro Nakayama, Taiji Kishi, Masao Sato, Ikuo Ikeda & Katsumi Imaizumi

  2. Kumamoto Prefecture University, Kumamoto, Japan

    Michihiro Sugano

Authors
  1. Octavio Carvajal
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  2. Masahiro Nakayama
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  3. Taiji Kishi
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  4. Masao Sato
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  5. Ikuo Ikeda
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  6. Michihiro Sugano
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  7. Katsumi Imaizumi
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Correspondence to Katsumi Imaizumi.

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Carvajal, O., Nakayama, M., Kishi, T. et al. Effect of medium-chain fatty acid positional distribution in dietary triacylglycerol on lymphatic lipid transport and chylomicron composition in rats. Lipids 35, 1345–1352 (2000). https://doi.org/10.1007/s11745-000-0651-6

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  • DOI: https://doi.org/10.1007/s11745-000-0651-6

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