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Multi-Day Monitoring of Ubidecarenone Level in Rat Plasma and Tissues After a Single Intravenous Injection

  • MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
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Pharmaceutical Chemistry Journal Aims and scope

The pharmacokinetics of ubidecarenone (CoQ10) in rat plasma and the kinetics of its organ levels were studied for the first time for 8-16 d after a single i.v. injection at a dose of 30 mg/kg. The pharmacokinetics followed a classical two-compartment curve. The main pharmacokinetic parameters for plasma (C 0, AUC 0→∞, K α, K el, t 1/2α, t 1/2el, Cl T, V d) and several organs (C max, T max, AUC 0→t , f tiss) were calculated. The results proved that CoQ10 injected i.v. rapidly attained and maintained for a long time high levels in plasma, myocardium, brain, liver, and kidneys. This was potentially important for treating acute ischemic states.

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Acknowledgments

The studies were sponsored by a grant of the Russian Scientific Foundation (Project No. 14-15-00126).

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Authors and Affiliations

  1. Department of Fundamental Medicine, M. V. Lomonosov Moscow State University, 31/5 Lomonosovskii Prosp., Moscow, 119192, Russia

    E. I. Kalenikova, E. A. Gorodetskaya, O. G. Tokareva, M. A. Belousova, O. Yu. Kulyak, M. M. Artem’eva & O. S. Medvedev

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  1. E. I. Kalenikova
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  2. E. A. Gorodetskaya
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  3. O. G. Tokareva
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  4. M. A. Belousova
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  5. O. Yu. Kulyak
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  6. M. M. Artem’eva
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  7. O. S. Medvedev
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Corresponding author

Correspondence to E. I. Kalenikova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 11, pp. 3 – 7, November, 2015.

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Kalenikova, E.I., Gorodetskaya, E.A., Tokareva, O.G. et al. Multi-Day Monitoring of Ubidecarenone Level in Rat Plasma and Tissues After a Single Intravenous Injection. Pharm Chem J 49, 719–723 (2016). https://doi.org/10.1007/s11094-016-1360-y

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  • DOI: https://doi.org/10.1007/s11094-016-1360-y

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