Abstract
Ischemic stroke is the second leading cause of mortality and disability globally. Neuronal damage following ischemic stroke is rapid and irreversible, and eventually results in neuronal death. In addition to activation of cell death signaling, neuroinflammation is also considered as another pathogenesis that can occur within hours after cerebral ischemia. Under physiological conditions, subcellular organelles play a substantial role in neuronal functionality and viability. However, their functions can be remarkably perturbed under neurological disorders, particularly cerebral ischemia. Therefore, their biochemical and structural response has a determining role in the sequel of neuronal cells and the progression of disease. However, their effects on cell death and neuroinflammation, as major underlying mechanisms of ischemic stroke, are still not understood. This review aims to provide a comprehensive overview of the contribution of each organelle on these pathological processes after ischemic stroke.
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Data availability statement
The data sets used during the current study are available from the corresponding author on reasonable request.
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The authors acknowledge the support of the Tehran University of Medical Sciences, Tehran, Iran.
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FK, FR and GA designed the outline of the manuscript. GA, SEK and FR drafted the manuscript. AH and FK revised the work. FR and SEK prepared the figures.
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Ryan, F., Khoshnam, S.E., Khodagholi, F. et al. How cytosolic compartments play safeguard functions against neuroinflammation and cell death in cerebral ischemia. Metab Brain Dis 36, 1445–1467 (2021). https://doi.org/10.1007/s11011-021-00770-z
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DOI: https://doi.org/10.1007/s11011-021-00770-z