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Peptide Scaffolds: Flexible Molecular Structures With Diverse Therapeutic Potentials

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Abstract

Peptide scaffolds are diverse chemical structures providing a major base for drug development. Nature modifies a premature peptide with respect to a basic scaffold structure to create a mature and active peptide. Mimicking the natural scaffolds with desirable modifications i.e., scaffold-hopping will decrease the enormous efforts of chemical syntheses and testing for drug development. We have surveyed the scaffold-based compounds being used for anticancer, antiinfective, antiinflammatory and antidiabetic activities. Synthetic peptidomimetics like aptamers, dendrimers, arylamide foldamers, β peptides, d peptides etc. provide an anticipative picture for the therapeutic use of scaffold structures. Free energy based conformational analysis of peptidomimetics provides details of their structure–activity relationships. Diverse forms of such peptidomimetics with respect to their structure and applications are discussed alongwith the mimetics which reached clinical trials. The review gives an insight into the future panoramas of drug development and identifies few peptide scaffolds having diverse potential with chemical modifications.

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Acknowledgment

We acknowledge the financial support from CSIR for one of the author (Radhika Deshmukh) through CSIR-Junior Research Fellowship.

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  1. Environmental Genomics Division, National Environmental Engineering Research Institute, Nehru Marg, Nagpur, Maharashtra, 440020, India

    Radhika Deshmukh & Hemant J. Purohit

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  1. Radhika Deshmukh
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  2. Hemant J. Purohit
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Correspondence to Hemant J. Purohit.

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Deshmukh, R., Purohit, H.J. Peptide Scaffolds: Flexible Molecular Structures With Diverse Therapeutic Potentials. Int J Pept Res Ther 18, 125–143 (2012). https://doi.org/10.1007/s10989-011-9286-4

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