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Synthetic and Structural Routes for the Rational Conversion of Peptides into Small Molecules

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Computational Peptidology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1268))

Abstract

The demand for modified peptides with improved stability profiles and pharmacokinetic properties is driving extensive research effort in this field. The conversion of peptides into organic molecules, as traditional drugs, is a long and puzzled way. Many and versatile approaches have been described for designing peptide mimetics: the substitution of natural residues with modified amino acids and the rigidification and modification of the backbone are the main structural and chemical routes walked in medicinal chemistry. All of these strategies have been successfully applied to obtain active new compounds in molecular biology, drug discovery and design. Here we propose a panoramic review of the most common methods for the preparation of modified peptides and the most interesting findings of the last decade.

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Authors and Affiliations

  1. Department of Pharmacy, CIRPEB: Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, DFM-Scarl, University of Naples “Federico II”, 80134, Naples, Italy

    Pasqualina Liana Scognamiglio, Giancarlo Morelli & Daniela Marasco

  2. Center for Advanced Biomaterials for Health Care, Istituto Italiano di Tecnologia (IIT), 80125, Naples, Italy

    Pasqualina Liana Scognamiglio

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  1. Pasqualina Liana Scognamiglio
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  2. Giancarlo Morelli
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  3. Daniela Marasco
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Correspondence to Pasqualina Liana Scognamiglio or Daniela Marasco .

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Editors and Affiliations

  1. Center of Bioinformatics (COBI), School of Life Science and Technology, University of Electronic Science and Technology of China (UESTC), Chengdu, China

    Peng Zhou

  2. Center of Bioinformatics (COBI), School of Life Science and Technology, University of Electronic Science and Technology of China (UESTC), Chengdu, China

    Jian Huang

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Scognamiglio, P.L., Morelli, G., Marasco, D. (2015). Synthetic and Structural Routes for the Rational Conversion of Peptides into Small Molecules. In: Zhou, P., Huang, J. (eds) Computational Peptidology. Methods in Molecular Biology, vol 1268. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2285-7_8

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  • DOI: https://doi.org/10.1007/978-1-4939-2285-7_8

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