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Peptidomimetics in Medicinal Chemistry: The Art of Transforming Peptides to Drugs

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Recent Advances in Pharmaceutical Innovation and Research

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Abstract

A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. Small-molecule medicines acting as receptor ligands or enzyme inhibitors are produced using this method. The principles of synthetic methods behind the construction of peptidomimetic bioactive substances are described in this chapter on peptidomimetics. Topics include peptide scaffold-based peptidomimetics, which focuses on design and synthetic considerations, and the introduction and scope of peptidomimetics in chemistry in the synthetic pathway of amino acids. Medicinal chemistry peptidomimetic therapeutic uses and delivery methods are covered in detail. In this chapter, case studies of the design, synthesis and amino acid composition of fullerene-based peptidomimetics as anticancer and hepatoprotective medicines, as well as the analysis of fullerene-based smaller chain peptidomimetics targeting tuberculosis, are concentrated. The entire data analysis focuses on the development of ligands from hit to lead, demonstrating the effective use of peptidomimetics in drug discovery.

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  1. KIET School of Pharmacy, KIET Group of Institutions, Ghaziabad, India

    K. Nagarajan & Garima Kapoor

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  1. K. Nagarajan
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  2. Garima Kapoor
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Correspondence to Garima Kapoor .

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  1. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Mohali, India

    Prati Pal Singh

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Nagarajan, K., Kapoor, G. (2023). Peptidomimetics in Medicinal Chemistry: The Art of Transforming Peptides to Drugs. In: Singh, P.P. (eds) Recent Advances in Pharmaceutical Innovation and Research. Springer, Singapore. https://doi.org/10.1007/978-981-99-2302-1_9

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