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Fabrication and characterization of dodecylamine derived monodispersed mesoporous bioactive glass sub-micron spheres

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Abstract

This paper reports a facile method for fabricating monodispersed mesoporous bioactive glass sub-micron spheres (MBGS) using dodecylamine (DDA) as a catalyst and template agent in sol–gel process. The effects of synthesis conditions including the amount of DDA, temperature of hydrolysis and the volume ratio of alcohol to water (AW ratio) on the resulting particle size, morphology, monodispersity and pore size distribution of MBGS are investigated and discussed. The results indicate that the particle size, morphology, monodispersity and pore size distribution of MBGS depend on the amount of DDA, the temperature of hydrolysis and the AW ratio. Meanwhile, using DDA as the structure directing agent and hydrolysis catalyst under optimal synthesis conditions (e.g. 4 g DDA, hydrolysis temperature at 40 °C and AW ratio at 4) is in favor of obtaining MBGS with mesoporous surface structure, large specific surface area (362.073 m2 g−1), relatively homogeneous particle size (~560 nm) as well as good apatite-forming activity. The unique structure and properties may turn MBGS into a good candidate as a drug delivery carrier or an injectable biomaterial for bone tissue regeneration.

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Acknowledgments

This work was supported by the Key Project of the National Natural Science Foundation of China (Grant No. 50830101), National Natural Science Foundation of China (Grant No. 51072055, Grant No. 51172073, Grant No. 51202069), the National 973 project of China (2011CB606204), Research Fund for the Doctoral Program of Higher Education of China (20110172110002) and the Fundamental Research Funds for the Central University (2012ZP0001).

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Authors and Affiliations

  1. School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, People’s Republic of China

    Qing Hu, Xiaofeng Chen, Naru Zhao, Yuli Li & Cong Mao

  2. National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, 510006, People’s Republic of China

    Qing Hu, Xiaofeng Chen, Naru Zhao, Yuli Li & Cong Mao

  3. Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou, 510006, People’s Republic of China

    Qing Hu, Xiaofeng Chen, Naru Zhao, Yuli Li & Cong Mao

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  1. Qing Hu
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  2. Xiaofeng Chen
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  3. Naru Zhao
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  4. Yuli Li
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  5. Cong Mao
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Correspondence to Xiaofeng Chen.

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Hu, Q., Chen, X., Zhao, N. et al. Fabrication and characterization of dodecylamine derived monodispersed mesoporous bioactive glass sub-micron spheres. J Sol-Gel Sci Technol 69, 9–16 (2014). https://doi.org/10.1007/s10971-013-3167-6

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  • DOI: https://doi.org/10.1007/s10971-013-3167-6

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