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Synthesis and in vitro bioactivity of three-dimensionally ordered macroporous-mesoporous bioactive glasses; 45S5 and S53P4

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Abstract

Two different bioactive glasses, 45S5 (45SiO2–24.5CaO–24.5Na2O–6P2O5) and S53P4 (53SiO2–20CaO–23Na2O–4P2O5), were synthesized by the sol–gel method using dual-templating methods. Polymethyl methacrylate (PMMA) colloidal crystal used as a template component produced three-dimensionally ordered macroporous (3DOM) structure. Block copolymer, P123, used as a structure-directing agent and template component yielded either mesopores after calcination. The morphology of the 3DOM-mesoporous bioactive glasses (3DOM-MBGs) was observed using a scanning electron microscope. Additionally, energy dispersive spectrometer and inductively coupled plasma-optical emission spectrometry (ICP-OES) were used to confirm the elemental compositions of the samples. Specific surface area and mesopore size distribution were determined using the N2 adsorption–desorption method, where S53P4 glasses exhibited well-ordered mesoporous properties compared to 45S5 glasses. In vitro bioactivity test was performed by soaking the 3DOM-MBGs in a simulated body fluid at 37 °C for 7 days. Results indicated that 45S5 exhibited the ability to grow hydroxyapatite-like layer on the surfaces faster than S53P4.

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Acknowledgements

This study was supported by Walailak University Postgraduate Scholarship for Outstanding Students (Contract no. 02/2560) and financially supported by Walailak University Graduate Studies Research Fund (Contract no. 14/2561).

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  1. Functional Materials and Nanotechnology Center of Excellence, School of Science, Walailak University, Nakhon Si Thammarat, 80160, Thailand

    Reedwan Bin-Zafar Auniq, Nattawipa Pakasri & Upsorn Boonyang

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  1. Reedwan Bin-Zafar Auniq
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  2. Nattawipa Pakasri
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Correspondence to Upsorn Boonyang.

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Auniq, R.BZ., Pakasri, N. & Boonyang, U. Synthesis and in vitro bioactivity of three-dimensionally ordered macroporous-mesoporous bioactive glasses; 45S5 and S53P4. J. Korean Ceram. Soc. 57, 305–313 (2020). https://doi.org/10.1007/s43207-020-00050-z

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  • DOI: https://doi.org/10.1007/s43207-020-00050-z

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