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Facile synthesis, characterization, biocompatibility and protein loading/release property of zinc-doped hollow mesoporous bioactive glass nanospheres

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Abstract

We synthetized hollow mesoporous bioactive glass nanospheres (HMBGS) and zinc-doped hollow mesoporous bioactive glass nanospheres (Zn-HMBGS) in which 5 mol% zinc was substituted for calcium using polyacrylic acid (PAA) as a template agent in sol-gel process. Then investigated the effect of zinc doping on morphology, size, structure, apatite-forming ability, biocompatibility and Bovine serum albumin (BSA) loading/release property of HMBGS. Results showed that Zn-HMBGS with an average particle size of 98.87 ± 7.08 nm were successfully fabricated and doping zinc did not significantly affect the spherical morphology, nano-scaled particle size and hollow mesoporous structure, but inhibited apatite-forming ability and improved biocompatibility of HMBGS. Additionally, the Zn-HMBGS possessed high specific surface area (120.014 m2g−1), large mesoporous size (5.26 ~ 6.68 nm) and hollow structure, exhibiting high loading capacity (202.17 ± 3.74 mg/g) and sustained release property for BSA. Due to their advantageous hollow mesoporous structure, good biocompatibility and efficient loading and stable release for BSA molecules, Zn-HMBGS show great potential as drug delivery systems for tissue regeneration.

Graphical Abstract

Highlights

  • Zinc-doped hollow mesoporous bioactive glass nanospheres (Zn-HMBGS) were prepared.

  • Zn-HMBGS exhibited high loading capacity and sustained release property for BSA.

  • Zn-HMBGS show great potential as drug delivery systems for tissue regeneration.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (52362038, 52362041, 52072162, 51962014), the key Project of Jiangxi Natural Science Foundation (2020ACBL214008), Jiangxi Provincial Natural Science Foundation (20224BAB204020, 20232BAB204012, 20224BAB214024), the Science Foundation of Jiangxi Provincial Department of Education (GJJ2201006), Jingdezhen science and technology project (20212GYZD009-07) and National College Student Innovation and Entrepreneurship Training Program Support Project (NO. 202310408027).

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Authors and Affiliations

  1. School of Material Science and Engineering, Jingdezhen Ceramic University, Jingdezhen, 333403, China

    Qing Hu, Huidong Tang, Hezhen Wu, Wentao Li, XianJian Wang & Feng Jiang

  2. National Engineering Research Center for Domestic & Building Ceramics, Jingdezhen Ceramic University, Jingdezhen, 333001, China

    Qing Hu, Yanqiao Xu, Guo Feng, Jian Liang & Jianmin Liu

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  1. Qing Hu
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  2. Huidong Tang
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Qing Hu: Project administration, Conceptualization, Writing-review, editing, Supervision. Huidong Tang, Hezhen Wu, Yanqiao Xu, Wentao Li and Xianjian Wang: Methodology, Formal analysis, Writing-original draft preparation. Guo Feng, Feng Jiang: Formal analysis, Writing-Review & Editing. Jian Liang, Jianmin Liu: Conceptualization, Technical supports.

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Correspondence to Qing Hu or Yanqiao Xu.

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Hu, Q., Tang, H., Wu, H. et al. Facile synthesis, characterization, biocompatibility and protein loading/release property of zinc-doped hollow mesoporous bioactive glass nanospheres. J Sol-Gel Sci Technol (2024). https://doi.org/10.1007/s10971-024-06374-0

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