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Recent advances in understanding the structure, function, and biotechnological usefulness of the hemoglobin from the bacterium Vitreoscilla

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Abstract

The hemoglobin from the bacterium Vitreoscilla (VHb) is the first microbial hemoglobin that was conclusively identified as such (in 1986). It has been extensively studied with respect to its ligand binding properties and mechanisms, structure, biochemical functions, and the mechanisms by which its expression is controlled. In addition, cloning of its gene (vgb) into a variety of heterologous hosts has proved that its expression results substantial increases in production of a variety of useful products and ability to degrade potentially harmful compounds. Recent studies (since 2005) have added significant knowledge to all of these areas and shown the broad range of biotechnological applications in which VHb can have a positive effect.

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Abbreviations

CaMV:

Caulifower mosaic virus

Crp:

Catabolite repressor transcription regulator

2-CBA:

2-Chlorobenzoic acid

2,4-DNT:

2,4-Dinitrotoluene

Fnr:

Fumarate nitrate reductase transcription regulator

Hb:

Hemoglobin

VHb:

Vitreoscilla hemoglobin

Vgb :

Vitreoscilla hemoglobin gene

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Authors and Affiliations

  1. Biology Division, Department of Biological, Chemical, and Physical Sciences, Illinois Institute of Technology, Chicago, IL, USA

    Benjamin C. Stark

  2. Institute of Microbial Technology, Sector 39 A, Chandigarh, 160036, India

    Kanak L. Dikshit

  3. Department of Civil, Architectural, and Environmental Engineering, Illinois Institute of Technology, Chicago, IL, USA

    Krishna R. Pagilla

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  1. Benjamin C. Stark
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  2. Kanak L. Dikshit
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  3. Krishna R. Pagilla
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Correspondence to Benjamin C. Stark.

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Stark, B.C., Dikshit, K.L. & Pagilla, K.R. Recent advances in understanding the structure, function, and biotechnological usefulness of the hemoglobin from the bacterium Vitreoscilla . Biotechnol Lett 33, 1705–1714 (2011). https://doi.org/10.1007/s10529-011-0621-9

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