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Microbial Production of Functional Organic Acids

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Systems and Synthetic Biotechnology for Production of Nutraceuticals

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Abstract

As the low-molecular-weight organic compounds, organic acids, such as malate, alpha-ketoglutaric acid, citrate, and so on, have been applied in a wide range of industries, including food, cosmetic, detergent, pharmaceutical, polymer, and textile. Throughout the past century, a variety of valuable chemicals derived mainly from fossil resources have been introduced, and the market for these products continues to grow. However, public concerns over environmental pollution, greenhouse gas emissions, and the shortage of raw oils are increasing, and attention is turning to alternative, renewable sources of chemical products to reduce both dependency on oil reserves and carbon dioxide emissions into the environment. Most organic acids are intermediates in the metabolic pathways that occur naturally in microorganisms, can be used as substitutes for these products. This chapter mainly introduces the synthesis methods, strategies and research progress of citric acid, alpha-ketoglutaric acid, succinic acid, malic acid and other organic acids, especially the application of metabolic engineering, microbial fermentation and biotransformation in the synthesis of various organic acids.

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  1. Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, China

    Xueqin Lv, Jingjing Liu, Xian Yin, Liuyan Gu, Li Sun, Guocheng Du & Long Liu

  2. Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi, China

    Xueqin Lv, Jingjing Liu, Xian Yin, Liuyan Gu, Li Sun, Guocheng Du, Jian Chen & Long Liu

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    Long Liu

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    Jian Chen

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Lv, X. et al. (2019). Microbial Production of Functional Organic Acids. In: Liu, L., Chen, J. (eds) Systems and Synthetic Biotechnology for Production of Nutraceuticals . Springer, Singapore. https://doi.org/10.1007/978-981-15-0446-4_3

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