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Lipoprotein(a)

  • Book
  • © 2023

Overview

Editors:
  1. Karam Kostner

    1. Mater Hospital, University of Queensland, Brisbane, Australia

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  2. Gerhard M. Kostner

    1. Medical University of Graz, Graz, Austria

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  3. Peter P. Toth

    1. Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, USA

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  • Provides comprehensive coverage of lipoprotein(a) and its role in the development of cardiovascular disease
  • Highlights current and future therapies for combating high levels of lipoprotein(a)
  • Brings awareness to an often overlooked risk factor of heart attacks and other serious cardiovascular events

Part of the book series: Contemporary Cardiology (CONCARD)

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xvii
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  2. 60 Years of Lp(a) Research: From Ouchterlonys Double Diffusion to Copy Number Variation and a Significant Risk Factor for CHD

    • Gerd Utermann
    Pages 1-37

  3. Lp(a) Biochemistry, Composition, and Structure

    • Gerhard M. Kostner
    Pages 39-54

  4. Genetics of Lipoprotein(a)

    • Gerd Utermann
    Pages 55-73

  5. Lp(a) Metabolism

    • John S. Millar, Daniel J. Rader
    Pages 75-90

  6. Contemporary Aspects of Lp(a) Metabolism and Therapies Based on Tracer Kinetic Studies in Humans

    • Dick C Chan, Jing Pang, Gerald F Watts
    Pages 91-111

  7. Role of Proprotein Convertase Subtilisin Kexin Type 9 in Lipoprotein(a) Metabolism

    • Antonio Gallo, Kévin Chemello, Romuald Techer, Ali Jaafar, Gilles Lambert
    Pages 113-124

  8. The Role of Cell Surface Receptors in Lp(a) Catabolism

    • Lamia Ismail, Déanna Shea, Sally McCormick
    Pages 125-134

  9. Physiological Roles and Functions of Lipoprotein(a)

    • Zaid N. Safiullah, Thorsten Leucker, Steven R. Jones, Peter P. Toth
    Pages 135-158

  10. The Role of Lp(a) in Atherosclerosis: An Overview

    • Anastasiya Matveyenko, Marianna Pavlyha, Gissette Reyes-Soffer
    Pages 159-171

  11. Molecular Mechanisms of Lipoprotein(a) Pathogenicity: Tantalizing Clues and Unanswered Questions

    • Michael B. Boffa, Marlys L. Koschinsky
    Pages 173-187

  12. Thrombosis, Inflammation, and Lipoprotein(a): Clinical Implications

    • Maya S. Safarova, Patrick M. Moriarty
    Pages 189-206

  13. The Kidney Is the Heart of the Organs: Its Role in Lp(a) Physiology and Pathophysiology

    • Hans Dieplinger
    Pages 207-230

  14. Lp(a) as a Cardiovascular Risk Factor

    • Angela Pirillo, Alberico Luigi Catapano
    Pages 231-239

  15. Lp(a) and Aortic Valve Stenosis, Stroke, and Other Noncoronary Cardiovascular Diseases

    • Anne Langsted, Pia R. Kamstrup
    Pages 241-250

  16. Lipoprotein(a) in Cardiovascular Disease: Evidence from Large Epidemiological Studies

    • Peter Engel Thomas, Signe Vedel-Krogh, Børge G. Nordestgaard
    Pages 251-259

  17. Lipoprotein(a) and Immunity

    • O. I. Afanasieva, T. I. Arefieva, M. V. Ezhov, S. N. Pokrovsky
    Pages 261-274

  18. When Should We Measure Lipoprotein(a)?

    • Karam Kostner
    Pages 275-280

  19. Measurement of Lipoprotein(a) in the Clinical Laboratory

    • David Sullivan, Catherine Woolnough, Nimalie Perera, Jay Ramanathan, Tony Badrick
    Pages 281-295

  20. Standardization of Analytical Methods for the Measurement of Lipoprotein(a): Bridging Past and Future Initiatives

    • Noemie Clouet-Foraison, Tomas Vaisar, Santica M. Marcovina
    Pages 297-323
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Keywords

About this book

Lipoprotein(a) [Lp(a)] is a unique lipoprotein that has emerged as an independent risk factor for cardiovascular vascular disease.  Data from case control, epigenetic and mendelian randomization studies indicate that people with elevated Lp(a) have a two-fold to four-fold increased risk of cardiovascular events compared to people with low Lp(a) levels. Despite this risk, awareness of Lp(a) is still very low among health care providers. Even cardiologists often overlook Lp(a), in part because Lp(a) is not as well-understood as other risk factors and treatment options are still very limited. 

 

This book offers an authoritative and comprehensive overview of Lipoprotein(a). It provides an in-depth review of all aspects of Lp(a), from pathophysiology to metabolism. Chapters offer the reader a contemporary view of the important roles of Lp(a) as a risk factor for cardiovascular disease. In addition, this volume discusses the clinical implications of elevated Lp(a) and current and future therapies. 

 

Lipoprotein(a) is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in lipidology, cardiology, endocrinology, pharmacotherapy, and health promotion and disease prevention.


Editors and Affiliations

  • Mater Hospital, University of Queensland, Brisbane, Australia

    Karam Kostner

  • Medical University of Graz, Graz, Austria

    Gerhard M. Kostner

  • Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, USA

    Peter P. Toth

About the editors

Karam Kostner, MD, Ph.D., FRACP,  FCSANZ

Associate Professor of Medicine


University of Queensland and Mater Hospital

Brisbane, Australia





Gerhard M. Kostner, Ph.D.

Emeritus Professor of Biochemistry and Molecular Biology


Medical University of Graz, Austria


Graz, Austria




Peter P. Toth, M.D. , PhD, FAHA, FESC, FACC

Adjunct Professor of Medicine


Division of Cardiology


Johns Hopkins University School of Medicine

Baltimore, Maryland  USA

Bibliographic Information

  • Book Title: Lipoprotein(a)

  • Editors: Karam Kostner, Gerhard M. Kostner, Peter P. Toth

  • Series Title: Contemporary Cardiology

  • DOI: https://doi.org/10.1007/978-3-031-24575-6

  • Publisher: Humana Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023

  • Hardcover ISBN: 978-3-031-24574-9Published: 04 March 2023

  • Softcover ISBN: 978-3-031-24577-0Published: 05 March 2024

  • eBook ISBN: 978-3-031-24575-6Published: 03 March 2023

  • Series ISSN: 2196-8969

  • Series E-ISSN: 2196-8977

  • Edition Number: 1

  • Number of Pages: XVII, 443

  • Number of Illustrations: 16 b/w illustrations, 76 illustrations in colour

  • Topics: Cardiology, Internal Medicine

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