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Role of Proprotein Convertase Subtilisin Kexin Type 9 in Lipoprotein(a) Metabolism

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Lipoprotein(a)

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Proprotein convertase subtilisin kexin 9 (PCSK9) is a major modulator of low-density lipoprotein cholesterol (LDL-C) plasma concentrations through its inhibitory action on LDL receptor (LDLR) expression. As a result, PCSK9 inhibitors lower the circulating concentrations of LDL. Surprisingly, these therapeutic agents also reduce the plasma levels of another class of atherogenic lipoproteins, lipoprotein(a) [Lp(a)]. This observation has driven research aimed at elucidating the role of PCSK9 in Lp(a) metabolism. Is the interaction between PCSK9 and Lp(a) particles LDLR dependent? What are the molecular mechanisms involved? This chapter aims at providing the key insights into the PCSK9-Lp(a) axis based on recent fundamental and clinical research findings.

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Authors and Affiliations

  1. Laboratoire Inserm UMR 1188 DéTROI, Université de La Réunion, Saint-Pierre (Ile de La Réunion), France

    Antonio Gallo, Kévin Chemello, Romuald Techer, Ali Jaafar & Gilles Lambert

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  1. Antonio Gallo
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  2. Kévin Chemello
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  3. Romuald Techer
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  4. Ali Jaafar
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  5. Gilles Lambert
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Correspondence to Gilles Lambert .

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Editors and Affiliations

  1. Mater Hospital, University of Queensland, Brisbane, QLD, Australia

    Karam Kostner

  2. Medical University of Graz, Graz, Austria

    Gerhard M. Kostner

  3. Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Peter P. Toth

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Gallo, A., Chemello, K., Techer, R., Jaafar, A., Lambert, G. (2023). Role of Proprotein Convertase Subtilisin Kexin Type 9 in Lipoprotein(a) Metabolism. In: Kostner, K., Kostner, G.M., Toth, P.P. (eds) Lipoprotein(a). Contemporary Cardiology. Humana, Cham. https://doi.org/10.1007/978-3-031-24575-6_6

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