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Lp(a) and Aortic Valve Stenosis, Stroke, and Other Noncoronary Cardiovascular Diseases

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Lipoprotein(a)

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

High lipoprotein(a) [Lp(a)] levels are found in over one billion individuals worldwide. Based on decades of accumulating evidence from mechanistic, epidemiological, and genetic studies, Lp(a) is established as a likely causal risk factor for ischemic cardiovascular and, in particular, coronary artery disease. In recent years, large genetic epidemiologic studies have also provided compelling evidence for high Lp(a) levels as a strong, causal risk factor for calcific aortic valve stenosis. Accumulating evidence also points to high Lp(a) levels as a risk factor for ischemic stroke in adults and children. This chapter will summarize findings for Lp(a) and aortic valve stenosis, stroke, and other noncoronary cardiovascular diseases, focusing on findings from large genetic epidemiologic studies, and provide estimates for Lp(a) level thresholds for increased risk.

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Author information

Author notes

  1. Anne Langsted and Pia R. Kamstrup contributed equally with all other contributors.

Authors and Affiliations

  1. Department of Clinical Biochemistry, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark

    Anne Langsted

  2. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

    Anne Langsted

  3. Department of Clinical Biochemistry, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark

    Pia R. Kamstrup

  4. The Copenhagen General Population Study, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark

    Pia R. Kamstrup

Authors
  1. Anne Langsted
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  2. Pia R. Kamstrup
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Corresponding authors

Correspondence to Anne Langsted or Pia R. Kamstrup .

Editor information

Editors and Affiliations

  1. Mater Hospital, University of Queensland, Brisbane, QLD, Australia

    Karam Kostner

  2. Medical University of Graz, Graz, Austria

    Gerhard M. Kostner

  3. Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Peter P. Toth

Ethics declarations

PRK reports talks and consultancies sponsored by Physicians Academy of Cardiovascular Education (PACE), Silence Therapeutics and Novartis. AL has nothing to disclose.

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© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Langsted, A., Kamstrup, P.R. (2023). Lp(a) and Aortic Valve Stenosis, Stroke, and Other Noncoronary Cardiovascular Diseases. In: Kostner, K., Kostner, G.M., Toth, P.P. (eds) Lipoprotein(a). Contemporary Cardiology. Humana, Cham. https://doi.org/10.1007/978-3-031-24575-6_14

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  • DOI: https://doi.org/10.1007/978-3-031-24575-6_14

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  • Publisher Name: Humana, Cham

  • Print ISBN: 978-3-031-24574-9

  • Online ISBN: 978-3-031-24575-6

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