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Effects On Peripheral Nerve Function

  • Reference work entry
Drug Discovery and Evaluation

  • 1969 Accesses

Local Anesthetic Activity

General Considerations

One 1′ has to generally distinguish between conduction anesthesia, infiltration anesthesia, and surface anesthesia (Fromherz 1922; Schaumann 1938), and special pharmacological tests have been developed for each of these.

The mode of action of local anesthetics has been reviewed by Ritchie and Greengard (1966), Ritchie (1971), Borchard (1977), Steiner (1978), Butterworth and Strichartz (1990).

References and Further Reading

Borchard U (1979) Studies on the action mechanism and pharmacological characterization of local anesthetics. Habilitation Thesis of the High Faculty of Medicine of the University of Duesseldorf for Attainment of venia legendi. (Untersuchungen zum Wirkungsmechanismus und zur pharmakologischen Charakterisierung von Lokalanaesthetika. Habilitationsschrift Universität Düsseldorf)

Butterworth JF, Strichartz GR (1990) Molecular mechanisms of local anesthesia. Anesthesiol 72:711–734

Camougis G, Takman BH (1971)Nerve and...

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References and Further Reading

  • Aasheim G, Fink BR, Middaugh M (1974) Inhibition of rapid axoplasmatic transport by procaine hydrochloride. Anesthesiology 41:549–553

    Article  PubMed  CAS  Google Scholar 

  • Åkerman B (1985) A methodological study of spinal (subarachnoid) anesthesia in the rat and mouse. Br J Anesth 57:29–332

    Google Scholar 

  • Åkerman B, Arweström E, Post C (1988b) Local anesthetics potentiate spinal morphine antinociception. Anesth Analg 67:943–948

    PubMed  Google Scholar 

  • Åkerman B, Hellberg IB, Trossvik C (1988) Primary evaluation of the local anesthetic properties of the amino amide agent ropivacaine (LEA 103). Acta Anesthesiol Scand 32:571–578

    Article  Google Scholar 

  • Alexander S, Peters J, Mathie A, MacKenzie G, Smith A (2001) TiPS nomenclature Supplement 2001

    Google Scholar 

  • Allmark MG, Bachinski WM (1949) A method of assay for curare using rats. J Am Pharm Ass 38:43–45

    Article  CAS  Google Scholar 

  • Ames III A, Gurian BS (1960) Measurement of function in an in vitro preparation of mammalian central nervous tissue. J Neurophysiol 23:676–691

    PubMed  Google Scholar 

  • Anderson KE, Edström A (1973) Effect of nerve blocking agents on fast axonal transport of proteins in frog sciatic nerves in vitro. Brain Res 50:125–134

    Article  PubMed  CAS  Google Scholar 

  • Århem P, Frankenhaeuser B (1974) Local anesthetics: effects on permeability properties of nodal membrane in myelinated nerve fibres from Xenopus. Potential clamp experiments. Acta Physiol Scand 91:11–21

    Article  PubMed  Google Scholar 

  • Åström A, Persson NH (1960) The toxicity of some local anesthetics after application on different mucous membranes and its relation to anesthetic action on the nasal mucosa of the rabbit. J Pharmacol Exp Ther 132:87–90

    Google Scholar 

  • Åström A, Persson NH (1961) Some pharmacological properties of o-methyl-α-propyl-amino-propionanilide, a new local anesthetic. Br J Pharmacol 16:32–44

    Google Scholar 

  • Bahar M, Nunn JF, Rosen M, Flecknell P (1984b) Differential sensory and motor blockade after spinal cocaine in the rat and marmoset. Eur J Anaesthesiol 1:31–36

    PubMed  CAS  Google Scholar 

  • Bahar M, Rosen M, Vickers MD (1984a) Chronic cannulation of the intradural and extradural space in the rat. Br J Anaesth 56:405–410

    Article  PubMed  CAS  Google Scholar 

  • Bartsch W, Knopf KW (1970) Eine modifizierte Methode zur Prüfung der Oberflächenanästhesie an der Kaninchen-Cornea. Arzneim Forsch/Drug Res 20:1140–1143

    CAS  Google Scholar 

  • Beani L, Bianchi C, Ledda F (1964) The effect of tubocurarine on acetylcholine release from motor nerve terminals. J Physiol 174:172–183

    PubMed  CAS  Google Scholar 

  • Bein HJ, Bucher K (1957) Anästhetische Wirkung an Lungendehnungsrezeptoren und anderen nervösen Substraten. (Zur Pharmakologie des Tessalon). Helv Physiol Acta 15:55–62

    CAS  Google Scholar 

  • Benz FW, Long JP (1969) Investigations on a series of heterocyclic hemicholinium-3 analogs. J Pharm Exp Ther 166:225–236

    CAS  Google Scholar 

  • Bianchi C (1956) A simple new quantitative method for testing local anaesthetics. Br J Pharmacol 11:104–106

    CAS  Google Scholar 

  • Bieter RN, Cunningham RW, Lenz OA, McNearney JJ (1936a) Threshold anesthetic and lethal concentrations of certain spinal anesthetics in the rabbit. J Pharmacol Exp Ther 57:221–244

    CAS  Google Scholar 

  • Bieter RN, McNearney JJ, Cunningham RW, Lenz OA (1936b) On the duration of spinal anesthesia in the rabbit. J Pharmacol Exp Ther 57:264–273

    CAS  Google Scholar 

  • Birmingham AT, Hussain SZ (1980) A comparison of the skeletal neuromuscular and autonomic ganglion-blocking potencies of five non-depolarizing relaxants. Br J Pharmacol 70:501–506

    Article  PubMed  CAS  Google Scholar 

  • Biró K, Pálhalmi J, Tóth AJ, Kukorelli T, Juhász G (1998) Bimoclomol improves early electrophysiological signs of retinopathy in diabetic rats. NeuroReport 9:2029–2033

    Article  PubMed  Google Scholar 

  • Block F, Schwarz M (1998) The b-wave of the electroretinogram as an index of retinal ischemia. Gen Pharmac 30:281–287

    Article  CAS  Google Scholar 

  • Blomberg S, Rickstein SE (1988) Thoracic epidural anesthesia in conscious and anesthetized rats. Effects on central haemodynamics compared to cardiac beta adrenoceptor and ganglionic blockade. Acta Anaesthesiol Scand 32:166–172

    Article  PubMed  CAS  Google Scholar 

  • Borchard U (1975) The effect of dimethylsulfoxide (DMSO) on the bioelectric activity of the isolated retina. Pflügers Arch Suppl 355:R111

    Google Scholar 

  • Borchard U (1978) Untersuchungen zum Wirkungsmechanismus und zur pharmakologischen Charakterisierung von Lokalanästhetika. Habilitationsschrift. Medizinische Fakultät, Universität Düsseldorf

    Google Scholar 

  • Borchard U (1979) Studies on the action mechanism and pharmacological characterization of local anesthetics. Habilitation Thesis of the High Faculty of Medicine of the University of Duesseldorf for Attainment of venia legendi

    Google Scholar 

  • Borchard U, Drouin H (1978) Effects of the antituberculous agent ethambutol on myelinated nerve. Eur J Pharmacol 50:307–316

    Article  PubMed  CAS  Google Scholar 

  • Borchard U, Drouin H (1980) Carticaine: action of the local anesthetic on myelinated nerve fibres. Eur J Pharmacol 62:73–79

    Article  PubMed  CAS  Google Scholar 

  • Borchard U, Erasmi W (1974) Na+ diffusion in the retinal tissue of the frog. Vision Res 14:17–22

    Article  PubMed  CAS  Google Scholar 

  • Bowman WC, Goldberg AAJ, Raper C (1962) A comparison between the effects of a tetanus and the effects of sympathomimetic amines on the fast- and slow-contracting mammalian muscles. Br J Pharmacol 19:464–484

    CAS  Google Scholar 

  • Bowman WC, Rodger IW, Houston J, Marshall RJ, McIndewar I (1988) Structure: action relationships among some desacetoxy analogues of pancuronium and vecuronium in the anesthetized cat. Anesthesiology 69:57–62

    Article  PubMed  CAS  Google Scholar 

  • Brown KM, Dennis JS (1972) Derivative free analogs of the Levenberg-Marquardt and Gauss algorithms for non-linear least square approximation. Numer Math 18:288–297

    Google Scholar 

  • Bräu ME, Vogel W, Hempelmann G (1998) Fundamental properties of local anesthetics: half-maximal blocking concentrations for tonic block of Na+ and K+ channels in peripheral nerve. Anesth Analg 87:885–889

    PubMed  Google Scholar 

  • Bucher K (1956) Tessalon, ein hustenstillendes Mittel von neuartigem Wirkungsmechanismus. Schweiz Med Wschr 86:94–96

    PubMed  CAS  Google Scholar 

  • Buckley FP, Duval Neto G, Fink BR (1985) Acid and alkaline solutions of local anesthetics: duration of nerve block and tissue pH. Anesth Analg 64:477–482

    Article  PubMed  CAS  Google Scholar 

  • Buckley FP, Fink BR (1981) Duration of action of nerve blocks produced by mixtures of local anesthetics and low molecular weight dextran: studies in rat infraorbital nerve blocks. Anesth Analg 60:142–145

    Article  PubMed  CAS  Google Scholar 

  • Burdyga TV, Magura IS (1986) The effects of local anaesthetics on the electrical and mechanical activity of the guinea-pig ureter. Br J Pharmacol 88:523–530

    Article  PubMed  CAS  Google Scholar 

  • Burn JH, Finney DJ, Goodwin LG (1952) Biological Standardization. Chapter XX, Curare-like compounds. Oxford University Press, London, New York, Toronto, pp 345–354

    Google Scholar 

  • Butterworth IVJF, Strichartz GR (1990) Molecular mechanisms of local anesthesia: a review. Anesthesiology 72:711–734

    Article  PubMed  CAS  Google Scholar 

  • Butterworth JF, Strichartz GR (1990) Molecular mechanisms of local anesthesia. Anesthesiol 72:711–734

    Article  CAS  Google Scholar 

  • Bülbring E (1946) Observations on the isolated phrenic nerve diaphragm preparation of the rat. Br J Pharmacol 1:38–61

    Google Scholar 

  • Bülbring E, Chou TC (1947) The relative activity of prostigmine homologues and other substances as antagonists to tubocurarine. Br J Pharmacol 2:8–22

    Google Scholar 

  • Bülbring E, Wajda I (1945) Biological comparison of local anesthetics. J Pharmacol Exp Ther 85:78–84

    PubMed  Google Scholar 

  • Camougis G, Takman BH (1971) Nerve and nerve-muscle preparations (as applied to local anesthetics) In: Schwartz A (ed) Methods in Pharmacology, Vol 1, Appleton-Century-Crofts, Educational Division, Meredith Corp., New York. pp 1–40

    Google Scholar 

  • Catterall WA (1988) Structure and function of voltage-sensitive ion channels. Science 242:50–61

    Article  PubMed  CAS  Google Scholar 

  • Catterall WA (1992) Cellular and molecular biology of voltage-gated sodium channels. Physiol Rev 72:S15–S48

    PubMed  CAS  Google Scholar 

  • Chance MRA, Lobstein H (1944) The value of the guinea pig corneal reflex for tests of surface anaesthesia. J Pharm Exp Ther 82:203–210

    Google Scholar 

  • Chang CC, Chuang ST, Lee CY, Weio JW (1972) Role of cardiotoxin and phospholipase A in the blockade of nerve conduction and depolarization of skeletal muscle induced by cobra venom. Br J Pharmac 44:752–764

    Article  CAS  Google Scholar 

  • Chanimov M, Cohen ML, Grinspun Y, Herbert M, Reif R, Kaufman I (1997) Neurotoxicity after spinal anaesthesia induced by serial intrathecal injections of magnesium sulphate. Anaesthesia 52:223–228

    Article  PubMed  CAS  Google Scholar 

  • Chernyakova IV, Zhukov VN, Osipov SA, Shadiev AS, Skovpen TV (1994) Epidural and conduction anesthesia with azacaine in the experiment. Exp Clin Pharmacol 57:13–15

    CAS  Google Scholar 

  • Chiou CY, Long JP (1969) Effects of α,α`-bis-(dimethylammoniumacetaldehyde diethylacetal)-p,p'-diacetylbiphenyl bromide (DMAE) on neuromuscular transmission. J Pharm Exp Ther 167:344–350

    CAS  Google Scholar 

  • Clutton RE, Boyd C, Flora R, Payne J, McGrath CJ (1992) Autonomic and cardiovascular effects of neuromuscular blockade antagonism in the dog. Vet Surg 21:68–75

    Article  PubMed  CAS  Google Scholar 

  • Cohen SA, Barchi RL (1993) Voltage-dependent sodium channels. Int Rev Cytol 137C:55–103

    PubMed  CAS  Google Scholar 

  • Colbert WE, Wilson BF, Williams PD (1990) The effects of temperature on the experimental reliability of the isolated rat phrenic nerve/diaphragm preparation. J Pharmacol Meth 24:53–57

    Article  CAS  Google Scholar 

  • Cole DJ, Lin DM, Drummond JC, Shapiro HM (1990) Spinal tetracaine decreases central nervous system metabolisms during somatosensory stimulation in the rat. Can J Anesth 37:231–237

    Article  PubMed  CAS  Google Scholar 

  • Collier HOJ, Hall RA, Fieller EC (1949) Use of a rotating drum in assessing the activities of paralysant, convulsant and anaesthetic drugs. Analyst 74:592–596

    Article  PubMed  CAS  Google Scholar 

  • Condouris GA, Lagomarsino WE (1966) Adrenalectomy in rats and its influence on local anesthesia of peripheral nerves. J Pharmacol Exp Ther 152:417–424

    PubMed  CAS  Google Scholar 

  • Courtney KR (1975) Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA 968. J Pharm Exp Ther 195:225–236

    CAS  Google Scholar 

  • Courtney KR, Kendig JJ, Cohen EN (1978) Frequency-dependent conduction block: the role of nerve impulse pattern in local anesthetic potency. Anesthesiology 48:11–117

    Article  Google Scholar 

  • Cullen LK, Jones RS, Snowdon SL (1980) Neuromuscular activity in the intact dog: techniques for recording evoked mechanical responses. Br Vet J 136:154–159

    PubMed  CAS  Google Scholar 

  • D'Amour FE, Smith DL (1941) A method for determining loss of pain sensation. J Pharmacol Exp Ther 72:74–79

    Google Scholar 

  • De Jong RH (1980) Editorial views: differential nerve block by local anaesthetics. Anesthesiology 53:443–444

    Article  PubMed  Google Scholar 

  • De la Calle JL, Paíno CL (2002) A procedure for direct lumbar puncture in rats. Brain Res Bull 59:245–250

    Article  Google Scholar 

  • Defalque RJ, Stoelting VK (1966) Latency and duration of action of some local anesthetic mixtures. Anesth Analg 45:106–116

    Article  PubMed  CAS  Google Scholar 

  • Defalque RJ, Stoelting VK (1967) Latency and duration of action of common local anesthetics: an experimental evaluation. Anesth Analg 46:311–314

    Article  PubMed  CAS  Google Scholar 

  • Den Hertog (1974) The effect of carticain on mammalian non-myelinated nerve fibres. Eur J Pharmacol 26:175–178

    Article  PubMed  CAS  Google Scholar 

  • Denson DD, Bridenbaugh PO, Phero JC, Raj PP, Turner PA, Ohlweiler DF (1981) Evaluation of lidocaine spinal anesthesia in the Rhesus monkey. Anesth Analg 10:756–759

    Google Scholar 

  • Dirksen R, Lerou J, Bakker H, van Luijtelaar E, Nijhuis G, Gielen M, Booij L (1992) The dose-response and time-effect relationships of intrathecal bupivacaine in rats. The influence of epinephrine and pH. Acat Anaesth Scand 36:153–158

    Article  CAS  Google Scholar 

  • Dittmann EC, Zipf HF (1973) Schmerzauslösung und Pharmakologie der Lokalanästhetika. In: Kilian H. (Hgb.) Lokalanästhesie und Lokalanästhetika. Thieme Verlag Stuttgart, pp 76–144

    Google Scholar 

  • Dohi S, Takeshima R, Naito H (1987) Spinal cord blood flow during spinal anesthesia in dogs: the effects of tetracaine, epinephrine, acute blood loss, and hypercapnia. Anesth Analg 66:599–606

    Article  PubMed  CAS  Google Scholar 

  • Doly M, Cluzel J, Millerin M, Bonhomme B, Braquet P (1993) Prevention of chloroquine-induced electroretinographic damage by a new platelet-activating factor antagonist, BN 50730. Ophthalmic Res 25:314–318

    Article  PubMed  CAS  Google Scholar 

  • Drouin H (1976) Surface charges at nerve membranes. Bioelectrochem Bioenerget 3:222–229

    Article  CAS  Google Scholar 

  • Drouin H, Neumcke (1974) Specific and unspecific charges at the sodium channels of the nerve membrane. Pflügers Arch 351:207–229

    Article  PubMed  CAS  Google Scholar 

  • Durant NN, Bowman WC, Marshall IG (1977) A comparison of the neuromuscular and autonomic blocking activities of (+)-tubocurarine and its N-methyl and O,O,N-trimethyl analogues. Eur J Pharmacol 46:297–302

    Article  PubMed  CAS  Google Scholar 

  • Dvorak H, Manson MH (1930) Technique of spinal anesthesia in the dog. Proc Soc Exp Biol Med 28:344–347

    Google Scholar 

  • Estrade M, Grondin P, Cluzel J, Bonhomme B, Doly M (1998) Effect of a cGMP-specific phosphodiesterase inhibitor on retinal function. Eur J Pharmacol 352:157–163

    Article  PubMed  CAS  Google Scholar 

  • Ettaiche M, Fillacier K, Widmann C, Heurteaux C, Lazdunski M (1999) Riluzole improves functional recovery after ischemia in the rat retina. Invest Ophthalmol Vis Sci 40:729–736

    PubMed  CAS  Google Scholar 

  • Fatt P, Katz B (1951) An analysis of the end-plate potential recorded with an intra-cellular electrode. J Physiol 115:320–370

    PubMed  CAS  Google Scholar 

  • Feldman HS, Covino BG (1981) A chronic model for investigation of experimental spinal anesthesia in the dog. Anesthesiology 54:148–152

    Article  PubMed  CAS  Google Scholar 

  • Feldman HS, Covino BG (1988) Comparative motor-blocking effects of bupivacaine and ropivacaine, a new amino amide local anesthetic, in the rat and dog. Anesth Analg 67:1047–1052

    PubMed  CAS  Google Scholar 

  • Feldman HS, Dvoskin S, Halldin MH, Ask AL, Doucette AM (1997) Comparative anesthetic efficacy and pharmacokinetics of epidurally administered ropivacaine and bupivacaine in the sheep. Regional Anesthesia 22:451–460

    Article  PubMed  CAS  Google Scholar 

  • Fink BR, Aasheim G, Kish SJ, Croley TS (1975) Neurokinetics of lidocaine in the infraorbital nerve of the rat in vivo. Relation to sensory block. Anesthesiology 42:731–736

    Article  PubMed  CAS  Google Scholar 

  • Fink BR, Aasheim G, Levy BA (1978) Neural pharmacokinetics of epinephrine. Anesthesiology 48:263–266

    Article  PubMed  CAS  Google Scholar 

  • Fink BR, Cairns AM (1984) Differential slowing and block of conduction by lidocaine in individual afferent myelinated and unmyelinated axons. Anesthesiology 60:111–120

    Article  PubMed  CAS  Google Scholar 

  • Fink BR, Kennedy RD, Hendrickson AE, Middaugh ME (1972) Lidocaine inhibition of rapid axonal transport. Anesthesiology 36:422–432

    Article  PubMed  CAS  Google Scholar 

  • Fromherz K (1922) Über die Wirkung verschiedener Gruppen der Lokalanästhetika im Lichte verschiedener Untersuchungsmethoden. Naunyn-Schmiedeberg's Arch exp Path Pharmakol 93:72–91

    Google Scholar 

  • Furukawa T, Hanawa I (1955) Effects of some common cations on electroretinogram of the toad. Jap J Physiol 5:289–300

    Article  CAS  Google Scholar 

  • Fußgänger R, Schaumann O (1931) Über ein neues Lokalanästhetikum der Novokainreihe (Pantokain). Naunyn-Schmiedeberg's Arch exp Path Pharmakol 160:53–65

    Article  Google Scholar 

  • Gerlough TD (1931) The influence of pH on the activity of certain local anesthetics as measured by the rabbit's cornea method. J Pharmacol Exp Ther 41:307–316

    CAS  Google Scholar 

  • Geßner O, Klenke J, Wurbs FR (1932) Die Lokalanästhetika Pantokain (I.G. Farben) und Larokain (Roche) im Vergleich zu Novokain. Naunyn-Schmiedeberg's Arch exp Path Pharmakol 168:447–472

    Article  Google Scholar 

  • Gissen AJ, Covino BG, Gregus J (1980) Differential sensitivities of mammalian nerve fibers to local anesthetic agents. Anesthesiology 53:467–474

    Article  PubMed  CAS  Google Scholar 

  • Gonzales E, Luduena FP (1961) Experimental spinal anaesthesia produced by members of a homologous series. J Med Pharm Chem 3:555–560

    Article  Google Scholar 

  • Gosbell A, Favilla I, Jablonski P (1996) The effects of insulin on the electroretinogram of bovine retina in vitro. Curr Eye Res 15:1132–1137

    Article  PubMed  CAS  Google Scholar 

  • Grant GJ, Piskoun B, Lin A, Bansinath M (2000) An in vivo method for the quantitative evaluation of local anesthetics. J Pharmacol Toxicol Meth 43:69–72

    Article  CAS  Google Scholar 

  • Grant GJ, Vermeulen K, Langerman L, Zakowski M, Turndorf H (1994) Prolonged analgesia with liposomal bupivacaine in a mouse model. Reg Anesth 19:264–269

    PubMed  CAS  Google Scholar 

  • Grant GJ, Vermeulen K, Zakowski MI, Langerman L (2001) Perineural antinociceptive effects of opioids in a rat model. Acta Anaesthesiol Scand 45:906–910

    Article  PubMed  CAS  Google Scholar 

  • Grant GJ, Vermeulen K, Zakowski MI, Sutin KM, Ramanathan S, Langerman L, Weisman TE, Turndorf H (1992) A rat sciatic nerve model for independent assessment of sensory and motor block induced by local anesthetics. Anesth Analg 75:889–894

    Article  PubMed  CAS  Google Scholar 

  • Grant GJ, Zakowski MI, Vermeulen K, Langerman L, Ramanathan S, Turndorf H (1993) Assessing local anesthetic effect using the mouse tail flick test. J Pharm Toxicol Meth 29:223–226

    Article  CAS  Google Scholar 

  • Grouls RJE, Meert TF, Korsten HHM, Hellebrekers LJ, Breimer DD (1997) Epidural and intrathecal n-butyl-p-aminobenzoate solution in the rat: comparison with bupivacaine. Anesthesiology 86:181–187

    Article  PubMed  CAS  Google Scholar 

  • H.G Vogel (2006) Peripheral Nervous System In: Drug Discovery and Evaluation Safety and Pharmacokinetic Assays, Chapter I.H, pp-195-209 H. G. Vogel (ed) F.J. Hock, J. Maas, D. Mayer (Co-eds) Springer-Verlag Berlin Heidelberg New York

    Google Scholar 

  • Haffner F (1929) Experimentelle Prüfung schmerzstillender Mittel. Dtsch Med Wschr 55:731–733

    Article  Google Scholar 

  • Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflüger's Arch 391:85–100

    Article  CAS  Google Scholar 

  • Hampl KF, Schneider MC, Ummenhofer W, Drews J (1995) Transient neurological symptoms after spinal anesthesia. Anesth Analg 81:1148–1153

    PubMed  CAS  Google Scholar 

  • Harkins JD, Mundy GD, Stanley S, Sams RA, Tobin T (1997) Lack of local anaesthetic efficacy of Sarapin in the abaxial sesamoid block. J Vet Pharmacol Ther 20:229–232

    Article  PubMed  CAS  Google Scholar 

  • Harkins JD, Mundy GD, Stanley S, Woods WE, Rees WA, Thompson KN, Tobin T (1996) Determination of highest no effect dose (HNED) for local anaesthetic responses to procaine, cocaine, bupivacaine and benzocaine. Equine Vet J 28:30–37

    Article  PubMed  CAS  Google Scholar 

  • Hassan HG, Pilcher CW, Akerman B, Renck H (1989) Antinociceptive effects of localized administration of opioids compared with lidocaine. Reg Anesth 14:138–144

    PubMed  CAS  Google Scholar 

  • Hassan HG, Youssef H, Renck H (1993) Duration of experimental nerve block by combination of local anesthetic agents. Acta Anaesthesiol Scand 37:70–74

    Article  PubMed  CAS  Google Scholar 

  • Herr F, Nyiri M, Pataky G (1953) Messung der Leitungs- und Infiltrationsanästhesie an Ratten mit einer neuen Methode. Naunyn-Schmiedeberg's Arch exp Path Pharmakol 217:207–216

    CAS  Google Scholar 

  • Hille B (1977a) The pH-dependent rate of action of local anesthetics on the node of Ranvier. J Gen Physiol 69:475–496

    Article  PubMed  CAS  Google Scholar 

  • Hille B (1977b) Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol 69:497–515

    Article  PubMed  CAS  Google Scholar 

  • Hoppe JO (1950) A pharmacological investigation of 2,5-bis-(3-diethylaminopropylamino)benzoquinone-bis-benzylchloride (WIN 2747) A new curarimimetic drug. J Pharmacol Exper Ther 100:333–345

    CAS  Google Scholar 

  • Hoppe JO (1955) Observations on the potency of neuromuscular blocking agents with particular reference to succinylcholine. Anesthesiol 16:91–124

    Article  CAS  Google Scholar 

  • Horiguchi M, Suzuki S, Kondo M, Tanikawa A, Miyake Y (1998) Effect of glutamate analogues and inhibitory neurotransmitters on the electroretinograms elicited by random sequence stimuli in rabbits. Invest Ophthalmol Vis Sci 39:2171–2176

    PubMed  CAS  Google Scholar 

  • Hotovy R (1956) Messung zentralanalgetischer Wirkungen mit der Régnierschen Methode. Arch Exp Path Pharmakol 228:387–402

    CAS  Google Scholar 

  • Hotta N, Nakamura J, Sakakibara F, Hamada Y, Hara T, Mori K, Nakashima E, Sasaki H, Kasama N, Inukai S, Koh N (1997) Electroretinogram in sucrose-fed diabetic rats treated with an aldose reductase inhibitor or an anticoagulant. Am J Physiol 273 (Endocrinol Metab 36) E965–E971

    Google Scholar 

  • Huang JC, Salt TE, Voaden J, Marshall J (1991) Non-competitive NMDA-receptor antagonists and anoxic degeneration of the ERG B-wave in vitro. Eye 5:467–480

    Article  Google Scholar 

  • Hughes PJ, Doherty MM, Charman WN (1993) A rabbit model for the evaluation of epidurally administered local anaesthetics. Anaesth Intens Care 21:298–303

    CAS  Google Scholar 

  • Hughes R (1984) Experimental and clinical evaluation of neuromuscular blocking agents. J Pharmacol Meth 12:1–27

    Article  CAS  Google Scholar 

  • Hughes R, Chapple DJ (1976a) Effects of non-depolarizing neuromuscular blocking agents on peripheral autonomic mechanisms in cats. Br J Anaesth 48:59–68

    Article  PubMed  CAS  Google Scholar 

  • Hughes R, Chapple DJ (1976b) Cardiovascular and neuromuscular effects of dimethyl tubocurarine in anaesthetized cats and rhesus monkeys. Br J Anaesth 48:847–852

    Article  PubMed  CAS  Google Scholar 

  • Hughes R, Chapple DJ (1981) The pharmacology of atracurium: a new competitive neuromuscular blocking agent. Br J Pharmacol 53:31–44

    CAS  Google Scholar 

  • Hunter JM (1995) New neuromuscular blocking drugs. New Engl J Med 332:1691–1699

    Article  PubMed  CAS  Google Scholar 

  • Hylden JLK, Wilcox GL (1980) Intrathecal morphine in mice: a new technique. Eur J Pharmacol 67:313–316

    Article  PubMed  CAS  Google Scholar 

  • Ide T, Okitsu Y, Nehashi S, Yamamoto F, Nishino T (2001) The effect of epidural anesthesia on respiratory distress induced by airway occlusion in isofluorane anesthetized cats. Anesth Analg 92:749–754

    Article  PubMed  CAS  Google Scholar 

  • Idänpään-Heikkilä JJ, Guilbaud G (1999) Pharmacological studies on a rat model of trigeminal neuropathic pain: baclofen, but not carbamazepine, morphine or tricyclic antidepressants, attenuates the allodynia-like behaviour. Pain 79:281–290

    Article  PubMed  Google Scholar 

  • Imai R, Sugimoto S, Ando T, Sato S (1991) A procedure for recording electroretinogram and visual evoked potential in freely moving cats. J Toxicol Sci 15:263–274

    Article  Google Scholar 

  • Jarkman S, Kato M, Bragadottir R (1998) Effects of pituitary adenylate-cyclase-activating polypeptide on the direct-current electroretinogram of the rabbit eye. Ophthalmic Res 30:199–206

    Article  PubMed  CAS  Google Scholar 

  • Jenden DJ (1955) The effect of drugs upon neuromuscular transmission in the isolated guinea pig diaphragm. J Pharmacol Exper Ther 114:398–408

    CAS  Google Scholar 

  • Jenden DJ, Kamijo K, Taylor DB (1994) The action of decamethonium on the isolated rabbit lumbrical muscle. J Pharmacol Exper Ther 111:229–240

    Google Scholar 

  • Jonas P, Bräu ME, Hermsteiner M, Vogel W (1989) Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels. Proc Natl Acad Sci USA 86:7238–7242

    Article  PubMed  CAS  Google Scholar 

  • Jones RD, Hamilton BF, Dass PD (1995) The effects of physostigmine on the electroretinogram in the Beagle dog. Vet Res Commun 19:135–147

    Article  PubMed  CAS  Google Scholar 

  • Kalichman MW (1993) Physiologic mechanisms by which local anesthetics may cause injury to nerve and spinal cord. Reg Anesth 18:448–452

    PubMed  CAS  Google Scholar 

  • Kamerling SG, Weckman TJ, Dequick DJ, Tobin T (1985) A method for studying cutaneous pain perception and analgesia in horses. J Pharmacol Meth 13:267–274

    Article  CAS  Google Scholar 

  • Kamibayachi T, Hayashi Y, Mammoto T, Yamatodani A, Taenaka N, Yoshiya I (1995) Thoracic epidural anesthesia attenuates halothane-induced myocardial sensitization to dysrhythmogenic effect of epinephrine in dogs. Anesthesiology 82:129–134

    Article  Google Scholar 

  • Karlin A, Akabas MH (1995) Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins. Neuron 15:1231–1244

    Article  PubMed  CAS  Google Scholar 

  • Karlsson U, Näsström J, Berge OG (1994) (±)-CP-96,345, an NK1 receptor antagonist, has localanesthetic-like effects in a mammalian sciatic nerve preparation. Regulatory Peptides 52:39–46

    Article  PubMed  CAS  Google Scholar 

  • Keesey JC (1989) AAEE Minimonograph 33: Electrodiagnosis approach to defects of neuromuscular transmission. Muscle Nerve 12:613–626

    Article  PubMed  CAS  Google Scholar 

  • Khuenl-Brady K, Castagnoli KP, Canfell PC, Caldwell JE, Agoston S, Miller RD (1990) The neuromuscular blocking effects and pharmacokinetics of ORG 9426 and ORG 9616 in the cat. Anesthesiology 72:669–674

    Article  PubMed  CAS  Google Scholar 

  • Kief H, Bähr H (1970) Epidural tolerance of artecaine in dogs. Personal communication

    Google Scholar 

  • Kim S-Y, Kwak J-S, Shin J-P, Lee S-H (1998) The protection of the retina from ischemic injury by the free radical scavenger Egb 761 and zinc in the cat retina. Ophthalmologica 212:268–274

    Article  PubMed  CAS  Google Scholar 

  • Kirihara Y, Saito Y, Sakura S, Hashimoto K, Kishimoto T, Yasui Y (2003) Comparative neurotoxicity of intrathecal and epidural lidocaine in rats. Anesthesiology 99:961–968

    Article  PubMed  CAS  Google Scholar 

  • Kohane DS, Sankar WN, Shubina M, Hu D, Rital N, Berde CB (1998) Sciatic nerve blockade in infant, adolescent, and adult rats. A comparison of ropivacaine with bupivacaine. Anesthesiology 89:1199–1208

    Article  PubMed  CAS  Google Scholar 

  • Kojima M, Takagi H (1969) Effects of some anticholinergic drugs on antidromic activity in the rat phrenic nerve-diaphragm preparation. Eur Pharmacol 5:161–167

    Article  CAS  Google Scholar 

  • Kozody R, Palahniuk RJ, Cumming RO (1985) Spinal cord flow following subarachnoid tetracaine. Can Anesth Soc J 32:23–29

    Article  CAS  Google Scholar 

  • Kraushaar AE, Schunk RW, Thym HF (1964) Ein neues Antitussivum: 2-(β-Hexamethyleniminoäthyl)-cyclo-hexanon-2-carbonsäure-benzylester HCl. Arzneim Forsch 14:986–995

    CAS  Google Scholar 

  • Kyles AE, Waterman A, Livingston A (1992) Chronic intrathecal catheterization in the sheep. J Pharmacol Toxicol Meth 27:177–183

    Article  CAS  Google Scholar 

  • Lambert LA, Lambert DH, Strichartz GR (1994) Irreversible conduction block in isolated nerve by high concentrations of local anesthetics. Anesthesiology 80:1082–1093

    Article  PubMed  CAS  Google Scholar 

  • Langerman L, Bansinath M, Grant GJ (1994) The partition coefficient as a predictor of local anesthetic potency for spinal anesthesia: Evaluation of five local anesthetics in a mouse model. Anesth Analg 79:490–494

    Article  PubMed  CAS  Google Scholar 

  • Langerman L, Golomb E, Benita S (1991) Spinal anesthesia: Significant prolongation of the pharmacologic effect of tetracaine with lipid solution of the agent. Anesthesiology 74:105–107

    Article  PubMed  CAS  Google Scholar 

  • Lavoie PA (1981) Importance of monovalent ions for the fast axonal transport of proteins. Can J Physiol Pharmacol 59:31–36

    Article  PubMed  CAS  Google Scholar 

  • Lavoie PA (1982) Block of fast axonal transport in vitro by the local anesthetics dibucaine and etidocaine. J Pharmacol Exp Ther 223:251–256

    PubMed  CAS  Google Scholar 

  • Lavoie PA (1983) Inhibition of fast axonal transport in vitro by the local anesthetics prilocaine, mepivacaine, and bupivacaine. Can J Physiol Pharmacol 61:1478–1482

    Article  PubMed  CAS  Google Scholar 

  • Lavoie PA, Khaten T, Filion PR (1989) Mechanisms of the inhibition of fast axonal transport by local anesthetics. Neuropharmacology 28:175–181

    Article  PubMed  CAS  Google Scholar 

  • Lebeaux M (1975) Sheep: a model for testing spinal and epidural anesthetic agents. Lab Anim Sci 25:629–633

    PubMed  CAS  Google Scholar 

  • Lee-Son S, Wang HK, Concus A, Crill E, Strichartz G (1992) Stereoselective inhibition of neuronal sodium channels by local anesthetics. Anesthesiology 77:324–335

    Article  PubMed  CAS  Google Scholar 

  • Lefebvre HP, Cardona A, Toutain PL, Morel E, Bach JF, Vernetder-Garabedian B (1992) A simple method for the quantitative evaluation of neuromuscular blockade in mice. J Pharm Toxicol Meth 27:129–133

    Article  CAS  Google Scholar 

  • Lembeck F (1953) Adrenalin, Noradrenalin und Corbasil als Zusatz zu Novocain. Arch exp Path Pharmacol 217:274–279

    CAS  Google Scholar 

  • Leszczynska K, Kau ST (1992) A sciatic nerve blockade method to differentiate drug-induced local anesthesia from neuromuscular blockade in mice. J Pharm Toxicol Meth 27:85–93

    Article  CAS  Google Scholar 

  • Levis S, Preat S, Dauby J (1953) Étude pharmacodynamique de deux séries de curarisants de synthèse. Arch Int Pharmacodyn 93:46–54

    PubMed  CAS  Google Scholar 

  • Li S, Mizota A, Adachi-Usami E (1999) Effects of intravitreal injection of botulinum toxin on the electroretinogram of rats. Ophthalmic Res 31:392–298

    Article  PubMed  CAS  Google Scholar 

  • Liang C, Peyman GA, Sun G (1998) Toxicity of intraocular lidocaine and bupivacaine. Am J Ophthalmol 125:191–196

    Article  PubMed  CAS  Google Scholar 

  • Litchfield JT Jr, Wilcoxon F (1949) A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 96:99–113

    PubMed  CAS  Google Scholar 

  • Long JP, Chiou CY (1970) Pharmacological testing methods for drugs acting on the peripheral nervous system. J Pharmaceut Sci 59:133–148

    Article  CAS  Google Scholar 

  • Long JP, Evans CT, Wong S (1967) A pharmacological evaluation of hemicholinium analogs. J Pharm Exp Ther 155:223–230

    CAS  Google Scholar 

  • Luduena FP (1957) Experimental spinal anesthesia. Arch Int Pharmacodyn 109:143–156

    PubMed  CAS  Google Scholar 

  • Luduena FP, Hoppe JO (1951) 2-Phenyl-4-thiazolidone derivatives as local anesthetics. J Am Pharm Ass 40:132–137

    Article  PubMed  CAS  Google Scholar 

  • Luduena FP, Hoppe JO (1952) Local anaesthetic activity, toxicity and irritancy of 2-alkoxy analogs of procaine and tetracaine. J Pharm Exp Ther 104:40–53

    CAS  Google Scholar 

  • Luduena FP, Hoppe JO, Coulston F, Drobeck HP (1960) The pharmacology and toxicology of mepivacaine, a new local anesthetic. Toxicol Appl Pharmacol 2:295–315

    Article  PubMed  CAS  Google Scholar 

  • MacIntosh (1938) The effect of preganglionic section on acetylcholine in the ganglion. J Physiol 92:22P

    Google Scholar 

  • Madan BR, Madan V, Pendse VK, Gupta RS (1970) A study of the antiarrhythmic and local anaesthetic actions of phencarbamide. Arch Int Pharmacodyn 185:53–65

    PubMed  CAS  Google Scholar 

  • Markham A, Faulds D (1996) Ropivacaine. A review of its pharmacology and therapeutic use in regional anaesthesia. Drugs 52:429–449

    Article  PubMed  CAS  Google Scholar 

  • Marshall RJ, Muir AW, Sleigh T, Savage DS (1994) An overview of the pharmacology of rocuronmium bromide in experimental animals. Eur J Anaesthesiol 11 [Suppl 9]:9–15

    Google Scholar 

  • Maynard KI, Arango PM, Chen D, Ogilvy CS (1998) Acetylsalicylate administered during simulated ischemia reduces the recovery of neuronal function in the in vitro rabbit retina. Neurosci Lett 249:159–162

    Article  PubMed  CAS  Google Scholar 

  • McGehee DS, Role LW (1995) Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons. Annu Rev Physiol 57:521–546

    Article  PubMed  CAS  Google Scholar 

  • McIntyre AR, Sievers RF (1937) The toxicity and anaesthetic potency of some alkoxy benzoates and related compounds. J Pharmacol Exp Ther 61:107–120

    CAS  Google Scholar 

  • Meier R, Bein HJ (1950) Neuere Befunde über die organisationsspezifischen Wirkungen am autonomen Nervensystem. Bull Schweiz Akad Med Wiss 6:209–233

    PubMed  CAS  Google Scholar 

  • Mestre C, Pélissier T, Fialip J, Wilcox G, Eschalier A (1994) A method to perform direct transcutaneous intrathecal injections in rats. J Pharmacol Toxicol Meth 32:197–200

    Article  CAS  Google Scholar 

  • Mochizuki K, Yamashita Y, Torisaki T, Komatsu K, Tanahashi T, Sakai H (1992) Intraocular penetration and effect on the retina of fluconazole. Les-Eye-Toxic-Res 9:537–546

    CAS  Google Scholar 

  • Muarata T, Murai T, Kanai T, Ogaki Y, Sanai K, Kanda H, Sato S, Kajikawa N, Umetsu T, Matsuura H, Fukatsu Y, Isogaya M, Yamada N, Nishio S (1989) General pharmacology of beraprost sodium. 2nd Communication: Effects on the autonomic, cardiovascular and gastrointestinal systems, and other effects. Arzneim Forsch/Drug Res 39:867–876

    Google Scholar 

  • Muir AW, Anderson K, Marshall RJ, Booij LHDJ, Crul FJ, Prior C, Bowman WC, Marshall IG (1991) The effects of a 16-N-homopyridine analogue of vecuronium in anesthetized cats, pigs, dogs and monkeys, and in isolated preparations.. Acta Anaesthesiol Scand 35:85–90

    Article  PubMed  CAS  Google Scholar 

  • Muir AW, Houston J, Green KL, Marshall RJ, Bowman WC, Marshall IG (1989) Effects of a new neuromuscular blocking agent (ORG 9426) in anaesthetized cats and pigs and in isolated nerve-muscle preparations. Br J Anaesth 63:400–410

    Article  PubMed  CAS  Google Scholar 

  • Muschaweck R, Habicht R, Rippel R (1986) Lokalanaesthetica. In: Ehrhart G, Ruschig H (eds) Arzneimittel. Entwicklung – Wirkung – Darstellung. Verlag Chemie GmbH, Weinheim, pp 1–44

    Google Scholar 

  • Muschaweck R, Kief H, Baehr H (1971) Comparative intrathecal tolerance of artcaine in dogs. Personal communication

    Google Scholar 

  • Muschaweck R, Rippel R (1974) Ein neues Lokalanästhetikum (Carticain) aus der Thiophenreihe. Prakt Anästh 9:135–146

    CAS  Google Scholar 

  • Myers RR, Sommer C (1993) Methodology for spinal neurotoxicity studies. Reg Anaesth 18:439–447

    CAS  Google Scholar 

  • Narahashi T, Herman MD (1992) Overview of toxins and drugs to study excitable membrane ion channels: I. Voltage-activated channels. Meth Enzymol 207:620–643

    Article  PubMed  CAS  Google Scholar 

  • Nieschulz O, Hoffmann I, Popendiker K (1958) Zur Pharmakologie des N-[4-(Phenoxy-methyl)-γ-phenyl-propyl]-morpholin, eines Aminoäthers mit lokalanaesthetischer Wirkung. Arzneim Forsch 8:539–544

    CAS  Google Scholar 

  • Nonner W (1969) A new voltage clamp method for Ranvier nodes. Pflügers Arch 309:176–192

    Article  PubMed  CAS  Google Scholar 

  • Nonner W, Rojas E, Stämpfli R (1974) Displacement currents in the node of Ranvier. Voltage and time dependence. Pflügers Arch 354:1–18

    Article  Google Scholar 

  • Ohtake K, Matsumoto A, Wakamatsu H, Kawai K, Nakakimura S, Sakabe T (2000) Glutamate release and neuronal injury after intrathecal injection of local anesthetics. Neuroreport 11:1105–1109

    Article  PubMed  CAS  Google Scholar 

  • Oka S, Matsumoto M, Ohtake K, Kiyoshima T, Nakakimura K, Sakabe T (2001) The addition of epinephrine to tetracaine injected intrathecally sustains an increase in glutamate concentrations in the cerebrospinal fluid and worsens neuronal injury. Anesth Analg 93:1050–1057

    Article  PubMed  CAS  Google Scholar 

  • Olschewski A, Hempelmann G, Vogel W, Safronow BV (1998) Blockade of Na+ and K+ currents by local anesthetics in the dorsal horn neurones of the spinal cord. Anesthesiology 88:172–179

    Article  PubMed  CAS  Google Scholar 

  • Olschewski A, Wolff M, Bräu ME, Hempelmann G, Vogel W, Safranow BV (2002) Enhancement of delayed-rectifier potassium conductance by low concentrations of local anesthetics in spinal sensory neurons. Br J Pharmacol 136:540–549

    Article  PubMed  CAS  Google Scholar 

  • Omote K, Iwasaki H, Kawamata M, Satoh O, Namiki A (1995) Effects of verapamil on spinal anesthesia with local anesthetics. Anesth Analg 80:444–448

    PubMed  CAS  Google Scholar 

  • Ono H, Saito KI, Kondo M, Morishita SI, Kato K, Hasebe Y, Nakayama M, Kato F, Nakamura T, Satoh M, Oka JI, Goto M, Fukuda H (1990) Effects of the new centrally acting muscle relaxant 7-chloro-N,N,3-trimethylbenzo[b]furan-2-carboxamide on motor and central nervous systems in rats. Arzneim Forsch/Drug Res 40:730–735

    CAS  Google Scholar 

  • Ossipov MH, Suarez LJ, Spaulding TC (1988) A comparison of antinociceptive and behavioral effects of intrathecally administered opiates, α-2-adrenergic agonists, and local anesthetics in mice and rats. Anesth Analg 67:616–624

    Article  PubMed  CAS  Google Scholar 

  • Ostwald P, Park SS, Toledano AY, Roth S (1997) Adenosine receptor blockade and nitric oxide synthase inhibition in the retina: Impact upon post-ischemic hyperemia and the electroretinogram. Vis Res 37:3453–3461

    Article  PubMed  CAS  Google Scholar 

  • Paterson JG, Hamilton JT (1970) A nerve chamber bioassay of local anesthetic activity. Arch Int Pharmacodyn 183:360–390

    PubMed  CAS  Google Scholar 

  • Paton WDM (1957) Histamine release by compounds of simple chemical structure. Pharmacol Rev 9:269–328

    PubMed  CAS  Google Scholar 

  • Paton WDM, Zaimis EJ (1948) Clinical potentialities of certain bisquarternary salts causing neuromuscular and ganglionic block. Nature 20:810

    Article  Google Scholar 

  • Paton WDM, Zaimis EJ (1951) The action of D-tubocurarine and of decamethonium on respiratory and other muscles in the cat. J Physiol 112:311–331

    PubMed  CAS  Google Scholar 

  • Piercey MF, Schroeder LA (1980) A quantitative analgesic assay in the rabbit based on response to tooth pulp stimulation. Arch Int Pharmacodyn Ther 248:294–304

    PubMed  CAS  Google Scholar 

  • Prior C, Dempster J, Marshall IG (1993) Electrophysiological analysis of transmission at the skeletal neuromuscular junction. J Pharm Toxicol Meth 30:1–17

    Article  CAS  Google Scholar 

  • Quevauviller A (1971) Experimental methods for comparing local anesthetic activity. In: Radouco-Thomas (ed) International Encyclopedia of Pharmacology and Therapeutics. Section 8: Local Anesthetics (Lechat P, Section editor) VolI, Pergamon Press, Oxford New York, pp 291–318

    Google Scholar 

  • Randic M, Straughan DM (1964) Antidromic activity in the rat phrenic nerve-diaphragm preparation. J Physiol 173:130–148

    PubMed  CAS  Google Scholar 

  • Raner C, Biber B, Lundberg J, Martiner J, Winsö O (1994) Cardiovascular depression by isofluorane and concomitant thoracic epidural anesthesia is reversed by dopamine. Acta Anesthesiol Scand 36:136–143

    Article  Google Scholar 

  • Ready LB, Fink BR (1980) Experimental evaluation of local anaesthetic solutions using rat infraorbital nerve block. Canad Anaesth Soc 27:58–61

    Article  CAS  Google Scholar 

  • Reichertz P, Zipf HF, Hansen K (1957) Vergleichende Prüfung verschiedener Endoanaesthetica an den Lungendehnungsrezeptoren des Meerschweinchens. Arzneim Forsch 7:739–742

    CAS  Google Scholar 

  • Reitzel NL, Long JP (1959) The neuromuscular properties of α ,α`-dimethylamino-4,4′-biacetophenone (hemicholinium). Arch Int Pharmacodyn 119:20–30

    PubMed  CAS  Google Scholar 

  • Renck H, Hassan HG (1992) Epinephrine as an adjuvant to amino-amid local anesthetics does not prolong the duration of action in infraorbital nerve block in the rat. Acta Anaesthesiol Scand 36:387–392

    Article  PubMed  CAS  Google Scholar 

  • Renck H, Hassan HG, Lindberg G, Akerman B (1988) Effects of macromolecular adjuvants on the duration of prilocaine. Experimental studies on the effect of variations of viscosity and sodium content and of inclusion of adrenaline. Acta Anaesthesiol Scand 32:355–364

    Article  PubMed  CAS  Google Scholar 

  • Richer JP, Lacoste L, Faure JP, Hauet T, Ferrié JC, Carretier M (1998) Sacrococcygeal and transsacral epidural aesthesia in the laboratory pig: a model for experimental surgery. Surg Radiol Anat 20:431–435

    Article  PubMed  CAS  Google Scholar 

  • Ritchie JM (1971) The mechanism of action of local anesthetic agents. In: Radouco-Thomas C (ed) International Encyclopedia of Pharmacology and Therapeutics. Section 8: Local Anesthetics. (P Lechat, Section editor), Vol 1, pp 131–166, Pergamon Press, Oxford New York

    Google Scholar 

  • Ritchie JM, Greengard P (1966) On the mode of action of local anesthetics. Ann Rev Pharmacol 6:405–430

    Article  PubMed  CAS  Google Scholar 

  • Ritchie JM, Ritchie B, Greengard P (1965a) The active structure of local anesthetics. J Pharmacol Exp Ther 150:152–159

    PubMed  CAS  Google Scholar 

  • Ritchie JM, Ritchie B, Greengard P (1965b) The effect of the nerve sheath on the action of local anesthetics. J Pharmacol Exp Ther 150:160–164

    PubMed  CAS  Google Scholar 

  • Rosenberg PH, Heinonen E (1983) Differential sensitivity of A and C nerve fibres to long-acting local anaesthetics. Br J Anaesth 55:163–167

    Article  PubMed  CAS  Google Scholar 

  • Rud J (1961) Local anesthetics. An electrophysiological investigation of local anesthesia of peripheral nerves with special reference to xylocaine. Acta Physiol Scand 51, Suppl 178:1–169

    Google Scholar 

  • Régnier MJ (1923) Essai de mesure de l'anesthésie produite sur les terminaisons nerveuses de la cornée par les anesthésiques locaux. Comparaison des pouvoirs anesthésiques de la cocaïne, de la novocaïne et de la stovaïne. CR hebd Scéances Acad Sci 177:558–560

    Google Scholar 

  • Safronov BV (1999) Spatial distribution of Na+ and K+ channels in spinal horn neurones. Role of the soma, axon and dendrites in spike generation. Prog Neurobiol 59:217–241

    Article  PubMed  CAS  Google Scholar 

  • Safronov BV, Wolff M, Vogel W (1997) Functional distribution of three types of Na+ channel on soma and processes of dorsal horn neurones of spinal cord. J Physiol (Lond) 503:371–385

    Article  CAS  Google Scholar 

  • Sakura S, Hashimoto K, Bollen AW, Ciriales R, Drasner K (1996) Intrathecal catheterization in the rat: improved technique for morphological analysis of drug-induced injury. Anesthesiology 85:1184–1189

    Article  PubMed  CAS  Google Scholar 

  • Salafsky B (1968) The effect of succinylcholine on denervated fast and slow skeletal muscle. Arch Intern Pharmacodyn 174:294–303

    CAS  Google Scholar 

  • Salako LA, Vaughan Williams EM, Wittig JH (1976) Investigations to characterize a new anti-arrhythmic drug, ORG 6001, including a simple test for calcium antagonism. Br J Pharmacol 57:251–262

    Article  PubMed  CAS  Google Scholar 

  • Sargent PB (1995) The diversity of neuronal nicotinic acetylcholine receptors. Annu Rev Neurosci 16:403–443

    Article  Google Scholar 

  • Savarese JJ (1979) The autonomic margins of safety of metocurine and d-tubocurarine in the cat. Anesthesiology 50:40–46

    Article  PubMed  CAS  Google Scholar 

  • Savarese JJ, Antonio RP, Ginsburg S (1975) Potential uses of short-acting nondepolarizing neuromuscular-blocking agents as predicted from animal experiments. Anesth Analg 54:669–678

    Article  PubMed  CAS  Google Scholar 

  • Saxen MA, Welch SP, Dewey WL (1993) The mouse paw withdrawal assay: a method for determining the effect of calcitonin gene-related peptide on cutaneous heat nociception latency time. Life Sci 53:397–405

    Article  PubMed  CAS  Google Scholar 

  • Schaumann O (1938) Chemie und Pharmakologie der Lokalanaesthetica. Naunyn-Schmiedeberg's Arch exp Path Pharmakol 190:30–51

    Article  CAS  Google Scholar 

  • Scurlock JE, Heavener JE, de Jong RH (1975) Differential B and C fibre block by an amide- and an ester-linked local anaesthetic. Br J Anaesth 47:1135–1139

    Article  PubMed  CAS  Google Scholar 

  • Sechzer PH (1965) The effect of organophosphates on nerve conduction. Arch Int Pharmacodyn 157:432–441

    PubMed  CAS  Google Scholar 

  • Sell R, Lindner E, Jahn H (1958) Untersuchungen über die Anästhesie der Dehnungs- und Berührungsrezeptoren durch einige Lokalanästhetika im Vergleich zur hustenstillenden Wirkung. Naunyn-Schmiedeberg's Arch exp Path Pharmakol 234:164–178

    Article  CAS  Google Scholar 

  • Shea TB, Flanagan LA (2001) Kinesin, dynein, and neurofilament transport. Trends Neurosci 24:644–648

    Article  PubMed  CAS  Google Scholar 

  • Sickel W, Lippmann HG, Haschke W, Baumann C (1960) Elektrogramm der umströmten menschlichen Retina. Ber Dtsch Ophthalm Ges 63:316–318

    Google Scholar 

  • Siemoneit KD, Zipf HF, Dittmann EC (1966) Untersuchungen zur endoanästhetischen und hypnotisch/narkotischen Wirkung von 2-Methoxy-4-allyl-phenoxyessigsäure-N,N′-diäthylamid (G29505) und verwandten Phenolderivaten. Arch Int Pharmacodyn 164:30–46

    PubMed  CAS  Google Scholar 

  • Siems KJ, Soehring K (1952) Die Ausschaltung sensibler Nerven durch peridurale und paravertebrale Injektion von Alkylpolyäthylenoxyd-äthern bei Meerschweinchen. Arzneim Forsch 2:109–111

    CAS  Google Scholar 

  • Sievers RF, McIntyre AR (1938) The toxicity and anesthetic potency of some new benzoyl derivatives. J Pharmacol Exp Ther 62:252–262

    CAS  Google Scholar 

  • Skinner HG, Young DM (1947) A mouse assay for curare. J Pharm Exper Ther 91:144–146

    CAS  Google Scholar 

  • Smith FL (1997) Regional cutaneous differences of bupivacaine local anesthesia in mice. Life Sci 60:1613–1621

    Article  PubMed  CAS  Google Scholar 

  • Sollmann T (1918) Comparative activity of local anesthetics. II. Paralysis of sensory fibres. J Pharmacol Exp Ther 11:1–7

    CAS  Google Scholar 

  • Sollmann T (1918) Comparison of activity of local anesthetics. IV. Anesthesia of rabbit's cornea. J Pharmacol Exp Ther 11:17–25

    CAS  Google Scholar 

  • Steiner R (1978) Zur Pharmakodynamik der Lokalanästhetika. In: Lokalanästhesie (Ahnefeld FW, Bergmann H, Burri C, Dick W, Halm\'agyi M, Hossli G, Rügheimer R, eds) Springer-Verlag Berlin Heidelberg New York, pp 17–23

    Google Scholar 

  • Štolc S, Mai PM (1993) Comparison of local anesthetic activity of pentacaine (trapencaine) and some of its derivatives by three different techniques. Pharmazie 48:210–212

    PubMed  Google Scholar 

  • Straub R (1956) Effects of local anesthetics on resting potential of myelinated nerve fibres. Experientia 12:182–184

    Article  PubMed  CAS  Google Scholar 

  • Stämpfli R (1954) A new method for measuring membrane potentials with external electrodes. Experientia 10:508–509

    Article  PubMed  Google Scholar 

  • Stämpfli R (1968) Voltage-Clamp-Analyse lokalanästhetischer Wirkungen am Ranvier'schen Schürring des Frosches. Naunyn-Schmiedeberg's Arch Pharmacol 260:P203–P204

    Article  Google Scholar 

  • Stämpfli R, Hille B (1976) Electrophysiology of the peripheral myelinated nerve. In: Llinás R, Precht W (eds) Frog Neurobiology. A Handbook. Springer Berlin, Heidelberg, New York. pp 3–32

    Google Scholar 

  • Stühmer W (1991) Structure-function studies of voltage-gated ion channels. Annu Rev Biophys Chem 20:65–78

    Article  Google Scholar 

  • Sugimoto S, Imawaka M, Ozaki H, Ito T, Ando T, Sato S (1994) A procedure for recording electroretinogram (ERG) with a contact lens-type electrode, and effects of sodium iodate on ERG in rats. J Pharmacol Toxicol Sci 19: Suppl 3:531–542

    Google Scholar 

  • Tagliati M, Bodis-Wollner I, Kovanecz I, Stanzione P (1994) Spatial frequency tuning of the monkey pattern ERG depends on D2 receptor-linked action of dopamine. Vis Res 34:2051–2057

    Article  PubMed  CAS  Google Scholar 

  • Takei K, Sato T, Nonoyama T, Miyauchi T, Goto K, Hommura S (1993) A new model for transient complete obstruction of retinal vessels induced by endothelin-1 injection into the posterior vitreous body in rabbits. Graefe's Arch Clin Exp Ophthalmol 231:476–481

    Article  CAS  Google Scholar 

  • The Local Anesthetics for Neuralgia Study Group (Riopelle JM, Coordinator) (1994) A surgically implantable nerve irrigation system for intermittent delivery of dissolved drugs: evaluation of long-term performance and histocompatibility in rats. J Pharmacol Toxicol Meth 31:221–232

    Google Scholar 

  • Ther L (1953a) Zur Prüfung der lokalanästhetischen Wirkung des Pantocain und des 4-n-Butylaminosalicylsäuredimethylaminoaethylesters im Tierversuch. Arzneim Forsch 3:345–348

    CAS  Google Scholar 

  • Ther L (1953b) Über ein neues Leitungsanaesthetikum der “Nirvanin”-Reihe mit großer Entgiftungsgeschwindigkeit (Hostacain). Naunyn-Schmiedeberg's Arch exp Path Pharmakol 220:300–316

    CAS  Google Scholar 

  • Ther L (1958) Zur pharmakologischen Beurteilung von lokalanaesthetisch wirksamen Substanzen unter besonderer Berücksichtigung ihrer Entgiftung. Med Chem 6:399–410

    Google Scholar 

  • Ther L, Lindner E (1961) Über die hustenstillende Wirkung von Lokalanästhetika. Medizin und Chemie (Weinheim), pp 351–357

    Google Scholar 

  • Ther L, Lindner E, Vogel G (1963) Zur pharmakodynamischen Wirkung der optischen Isomeren des Methadons. Dtsch Apoth Ztg 103:514–520

    CAS  Google Scholar 

  • Ther L, Mügge F (1953) Über ein neues Oberflächenanaestheticum in der Augenheilkunde (Cornecain). v. Graefes Arch Ophthalmol 154:244–252

    Article  CAS  Google Scholar 

  • Thesleff S (1958) A study on the interaction between neuromuscular blocking agents and acetylcholine at the mammalian motor end-plate. Acta Anaesth Scand 2:69–79

    Article  PubMed  CAS  Google Scholar 

  • Thut PD, Turner MD, Cordes CT, Wynn RL (1995) A rabbit tooth-pulp assay to quantify efficacy and duration of antinociception by local anesthetics infiltrated into maxillary tissue. J Pharmacol Toxicol Meth 33:231–236

    Article  CAS  Google Scholar 

  • Truant AP (1958) Studies on the pharmacology of meprylcaine (Oracaine), a local anesthetic. Arch Int Pharmacodyn 115:483–497

    PubMed  CAS  Google Scholar 

  • Truant AP (1965) Local anesthetic and toxicological properties of Citanest. Acta Anesth Scand Suppl XVI:19–22

    Article  Google Scholar 

  • Truant AP, Wiedling S (1958/59) A contribution to the pharmacological and toxicological evaluation of a new local anaesthetic, dl-N-methylpipecolyl-2,6-xylidide. Acta Chir Scand 116:351–361

    Google Scholar 

  • Turner RA (1965) Local and spinal anesthetics. In: Turner RA (ed) Screening Methods in Pharmacology. Academic Press, New York and London, pp 268–269

    Google Scholar 

  • Van Riezen H (1968a) Classification of neuromuscular blocking agents in a new neuromuscular preparation of the chick in vitro. Eur J Pharmacol 5:29–36

    Article  PubMed  Google Scholar 

  • Van Riezen H (1968b) Effect of cholinergic and anticholinergic drugs on a new neuromuscular preparation of the chick. Eur J Pharmacol 5:37–48

    Article  PubMed  Google Scholar 

  • Varney RF, Linegar CR, Holaday HA (1948) The rabbit ‘head-drop’ method for the biological assay of curare and its alkaloids. Fed Proc 7:261–262

    PubMed  CAS  Google Scholar 

  • Varney RF, Linegar CR, Holaday HA (1949) The assay of curare by the rabbit ‘head-drop’ method. J Pharmacol Exp Ther 97:72–83

    PubMed  CAS  Google Scholar 

  • Vizi ES, Tuba Z, Maho S, Foldes FF, Nagano O, Doda M, Takagi S, Chaudhry IA, Saubermann AJ, Nagashima H (2003) A new short-acting non-depolarizing muscle relaxant (SZ1677) without cardiovascular side effects. Acta Anaesthesiol Scand 47:291–300

    Article  PubMed  CAS  Google Scholar 

  • Vogel W, Schwarz JR (1995) Voltage clamp studies in axons: macroscopic and single-channel currents. In: Waxman SC, Kocsis JD, Stys PK (eds) The axon. Oxford University Press, Oxford, pp 257–280

    Chapter  Google Scholar 

  • von Frey M (1894) Beiträge zur Physiologie des Schmerzsinns. Ber Sächs Gesellsch Wiss, Leipzig, Math Phys Kl 46:185–195

    Google Scholar 

  • von Frey M (1896) Untersuchungen über die Sinnesfunctionen der menschlichen Haut. Erste Abhandlung: Druckempfindung und Schmerz. Abhandlungen der Mathematisch-physischen Classe der Königl. Sächsischen Gesellschaft der Wissenschaften 23:173–266

    Google Scholar 

  • von Frey M (1922) Versuche über schmerzerzeugende Reize. Z Biol 76:1–24

    Google Scholar 

  • Wagner JC, Sievers RF, Bennett AL, McIntyre AR (1940) Spinal anaesthesia in dogs. J Pharmacol Exp Ther 68:437

    CAS  Google Scholar 

  • Wakamatsu H, Matsumoto M, Nakakimura K, Sakabe T (1999) The effects of moderate hypothermia and intrathecal tetracaine on glutamate concentrations of intrathecal dialysate and neurologic outcome in transient spinal cord ischemia in rabbits. Anesth Analg 88:56–62

    PubMed  CAS  Google Scholar 

  • Walter P, Luke C, Sickel W (1999) Antibiotics and light responses in superfused bovine retina. Cell Mol Neurobiol 19:87–92

    Article  PubMed  CAS  Google Scholar 

  • Walts LF (1973) The “Boomerang” – a method for recording adductor pollicis tension. Can Anaesth Soc J 20:706–708

    Article  PubMed  CAS  Google Scholar 

  • Wang BC, Hillman DE, Li D, Turndorf H (1991) Lumbar subarachnoid catheterization in rats. Pharmacol Biochem Behav 38:685–688

    Article  PubMed  CAS  Google Scholar 

  • Weatherby JH (1964) Local anesthetics. In: Laurence DR, Bacharach AL (eds) Evaluation of Drug Activities: Pharmacometrics. Academic Press, London, New York, pp 205–214

    Google Scholar 

  • Wellhöner HH, Conrad B (1965) Über die Wirkung von Aconitin auf die Impulstätigkeit in afferenten Fasern aus Lungendehnungsrezeptoren. Naunyn-Schmiedeberg's Arch Exp Path Pharmakol 252:269–285

    Google Scholar 

  • Wessler I, Kilbinger H (1986) Release of [3H]acetylcholine from a modified rat phrenic nerve-hemidiaphragm preparation. Naunyn-Schmiedeberg's Arch Pharmacol 334:357–364

    Article  CAS  Google Scholar 

  • Wessler I, Steinlein O (1987) Differential release of [3H]acetylcholine from the rat phrenic nerve-hemidiaphragm preparation by electrical nerve stimulation and by high potassium. Neurosci 22:289–299

    Article  CAS  Google Scholar 

  • Wessler I, Wagner G, Walczok A (1992) Suppression by cholinesterase inhibition of a Ca2+-independent efflux of [3H]acetylcholine from the neuromuscular junction of the isolated rat diaphragm. Eur J Pharmacol 221:371–376

    Article  PubMed  CAS  Google Scholar 

  • West GB (1947) Note on the biological assay of tubocurarine. Quart J Pharm Pharmacol 20:518–527

    CAS  Google Scholar 

  • Wiedling S (1960) Studies on α-n-propylamino-2-methylpropionanilide – a new local anaesthetic. Acta Pharmacol Toxicol 17:233–244

    Article  CAS  Google Scholar 

  • Wiedling S (1964) Xylocaine. The pharmacological basis of its clinical use. Almqvist & Wiksell, Stockholm, Göteborg, Uppsala, pp 27–46

    Google Scholar 

  • Wildsmith JAW, Brown DT, Paul D, Johnson S (1989) Structure-activity relationships in differential nerve block at high and low frequency stimulation. Br J Anaesth 63:444–452

    Article  PubMed  CAS  Google Scholar 

  • Wildsmith JAW, Gissen AJ, Gregus J, Covino BG (1985) Differential nerve blocking activity of amino-ester local anaesthetics. Br J Anaesth 57:612–620

    Article  PubMed  CAS  Google Scholar 

  • Wildsmith JAW, Gissen AJ, Takman B, Covino BG (1987) Differential nerve blockade: esters v. amides and the influence of pKa. Br J Anaesth 59:379–384

    Article  PubMed  CAS  Google Scholar 

  • Wilson H, Long JP (1959) Effect of hemicholinium (HC-3) at various peripheral cholinergic transmitting sites. Arch Int Pharmacodyn 120:343–352

    PubMed  CAS  Google Scholar 

  • Wynn RL, El'Baghdady YM, Ford RD, Thut PD, Rudo FG (1984) A rabbit tooth-pulp assay to determine ED 50 values and duration of action of analgesics. J Pharmacol Meth 11:109–117

    Article  CAS  Google Scholar 

  • Yaksh TL, Grafe MR, Malkmus SAHT, Rathbun ML, Eisenach JC (1995) Studies on the safety of chronically administered neostigmine methylsulfate in rats and dogs. Anesthesiology 82:412–427

    Article  PubMed  CAS  Google Scholar 

  • Yaksh TL, Rudy TA (1976) Chronic catheterization of the spinal subarachnoid space. Physiol Behav 17:1031–1036

    Article  PubMed  CAS  Google Scholar 

  • Yanase J, Ogawa H (1997) Effects of halothane and sevoflurane on the electroretinogram of dogs. Am J Vet Res 58:904–909

    PubMed  CAS  Google Scholar 

  • Yim GKW, Keasling HH, Gross EG, Mitchell CW (1955) Simultaneous respiratory minute volume and tooth pulp threshold changes following levorphan, morphine and levorphan-levallorphan mixtures in rabbits. J Pharmacol Exp Ther 115:96–105

    PubMed  CAS  Google Scholar 

  • Zaimis E, Head S (1976) Depolarizing neuromuscular blocking drugs. In: Zaimis E (ed) Neuromuscular Junction. Handbook of Experimental Pharmacology, Vol 42, Springer-Verlag, Berlin, Heidelberg, New York, pp 365–419

    Google Scholar 

  • Zemel E, Loewenstein A, Lazar M, Perlman I (1995) The effects of lidocaine and bupivacaine on the rabbit retina. Docum Ophthalm 90:189–199

    Article  CAS  Google Scholar 

  • Zipf HF (1953) Die Endoanästhesie, ein pharmakologischer Weg zur Ausschaltung innerer sensibler Rezeptoren. Dtsch Med Wschr 78:1587–1589

    Article  PubMed  CAS  Google Scholar 

  • Zipf HF (1957) Lungensensibilität und ihre Ausschaltung durch Endoanästhesie. Klin Wschr 35:1031–1037

    Article  PubMed  CAS  Google Scholar 

  • Zipf HF (1959) Die Allgemeinwirkungen der Lokalanästhetika. In: Kilian H. (Hgb.) Lokalanästhesie und Lokalanästhetika. Thieme Verlag Stuttgart, pp 111–189

    Google Scholar 

  • Zipf HF (1966) The pharmacology of viscero-afferent receptors with special reference to endoanesthesia. Acta Neuroveg (Wien) 28:169–196

    Article  CAS  Google Scholar 

  • Zipf HF (1968) New light on the properties of local anaesthetics. Germ Med Mth 13:238–247

    Google Scholar 

  • Zipf HF, Dittmann EC, Marquardt H (1963) Lokalanästhetische und endoanästhetische Wirkungen von Tropeinen. Arzneim Forsch 13:1097–1100

    CAS  Google Scholar 

  • Zipf HF, Kreppel E, Wetzels E (1955) Untersuchungen zur Definition einer katelektrotonischen Form der Endoanaesthesie. Arch Exper Path Pharmakol 226:348–362

    CAS  Google Scholar 

  • Zipf HF, Oehler H (1955) Die Trachealverschlußreaktion nach HEAD, eine Hilfsmethode zum Nachweis endeoanästhetischer Wirkungen. Naunyn-Schmiedeberg's Arch exp Path Pharmakol 226:363–376

    CAS  Google Scholar 

  • Zipf HF, Reichertz P (1957) Darstellung der totalen und reversiblen Endoanästhesie der Lungendehungsrezeptoren durch Zeit/Wirkungskurven. Naunyn-Schmiedeberg's Arch exp Path Pharmakol 231:96–110

    CAS  Google Scholar 

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Vogel, H. (2007). Effects On Peripheral Nerve Function. In: Vogel, H.G. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70995-4_8

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