Characterization of the CO release properties of a common CO donor, CORM-401, in the context of its application in studying CO biology Nicola BauerQiyue MaoBinghe Wang Original Research Article 18 April 2024
Antitumor studies on celastrol and its derivatives as RORα agonists and RORγ inhibitors based on Alphafold reverse docking strategy Bangwen YueXiuli Wu Original Research Article 12 April 2024
Phenoxyalkyl cyclic and acyclic amine derivatives: what do they teach us about scaffold-based drug design? Mohammad Mahdi RezaeifarArdavan AbiriYaghoub Pourshojaei Review Article 10 April 2024
Synthesis and anticancer activity of novel coumarin-stilbene hybrids with different hydrocarbon chains as linkers Lamya A. Al-lehaibEhab M. M. AliReda M. El-Shishtawy Original Research Article 05 April 2024
Vital residues-orientated rational design of butenolide inhibitors targeting Of ChtI Qing HanYun-Jiang ZiHong-Xia Duan Brief Report 02 April 2024
Design, synthesis and antitumor activity evaluation of novel benzamide HDAC inhibitors Ci CaiYepeng Luan Original Research Article 28 March 2024
Design, synthesis, and in vitro biological evaluation of novel HDAC inhibitors bearing C-1 phenyl substituted tetrahydroisoquinoline Cap moiety as anti-tumor therapeutic agents Jie WangChi ZhouLei Liu Original Research Article 27 March 2024 Pages: 687 - 702
Diffractaic acid and its ethers as anti-respiratory syncytial virus agents Aleksandr S. FilimonovDiana U. IsmangulovaNariman F. Salakhutdinov Original Research Article 11 March 2024 Pages: 677 - 686
Synthesis, urease inhibitory and anticancer evaluation of glucosamine-sulfonylurea conjugates Ghadeer A. R. Y. SuaifanMayadah ShehadehMajid Khan Original Research Article 07 March 2024 Pages: 663 - 676
Motor and non-motor symptoms, drugs, and their mode of action in Parkinson’s disease (PD): a review Nancy SainiNeetu SinghHarvinder Singh Sohal Review Article 07 March 2024 Pages: 580 - 599
Evaluation of ortho-substituted Bis-Functionalized Triazoles as Tyrosinase Inhibitors: Modulating Dopamine Synthesis and Behavior in Zebrafish Shainaz LandgeJack PhilpVinoth Sittaramane Original Research Article 06 March 2024 Pages: 651 - 662
Bioassay-guided fractionations of Cannabis sativa extract and HPLC-assisted purifications of anti-proliferative active fractions lead to the isolation of 16 known and one new phytomolecule and their in-silico analysis Yedukondalu NalliSahil BhartiMahendra Kumar Verma Original Research Article 05 March 2024 Pages: 635 - 650
Design, synthesis, and biochemical and computational screening of novel oxindole derivatives as inhibitors of Aurora A kinase and SARS-CoV-2 spike/host ACE2 interaction Donatus B. EniJoel CasselFidele Ntie-Kang Original Research Article Open access 05 March 2024 Pages: 620 - 634
Evolution and challenges of opioids in pain management: Understanding mechanisms and exploring strategies for safer analgesics Toluwalope Temitope BakareHenrietta Onyinye UzoetoOlanrewaju Ayodeji Durojaye Review Article 29 February 2024 Pages: 563 - 579
Adenine derivatives as inhibitors of the casein kinase CK1delta enzyme Andrea SpinaciCatia LambertucciRosaria Volpini Original Research Article 28 February 2024 Pages: 611 - 619
Development of novel chalcone derivatives as multifunctional agents for the treatment of Alzheimer’s disease Xinjuan LiYuting LiZhipei Sang Original Research Article 26 February 2024 Pages: 548 - 561
2-Styrylchromones as inhibitors of α-amylase and α-glucosidase enzymes for the management of type 2 diabetes mellitus Clementina M. M. SantosCarina ProençaEduarda Fernandes Original Research Article Open access 24 February 2024 Pages: 600 - 610
Synthesis, characterization, and anticancer activity of syringaldehyde-derived chalcones against female cancers Qionghui PanHuamao YangFaqing Ye Original Research Article 19 February 2024 Pages: 532 - 547
Synthesis and pharmacological activities of Schiff bases with some transition metal complexes: a review Kibrom MezgebeEndale Mulugeta Review Article 19 February 2024 Pages: 439 - 463
The use of single-molecule FRET for the characterization of Holliday junctions containing human telomeric DNA: a methodological approach for nanoscale distance, mobility, and stability measurements Abeer F. R. AlanaziShozeb HaiderGary N. Parkinson Brief Report 19 February 2024
Targeting disease with benzoxazoles: a comprehensive review of recent developments Abdulrahman AbdullahiKeng Yoon Yeong Review Article Open access 18 February 2024 Pages: 406 - 438
Preliminary structure−activity relationships analysis on N-(3,5-dichlorophenyl)-4,5-dihydronaphtho[1,2-d]thiazol-2-amine, a disruptor of mycobacterial energetics Miriam GirardiniDiana MachadoMarco Pieroni Original Research Article 17 February 2024 Pages: 518 - 531
Insights on synthetic strategies and structure-activity relationship of donepezil and its derivatives Saraswati PatelSonika JainJaya Dwivedi Review Article 17 February 2024 Pages: 370 - 405
Identification of novel benzoyl hydrazine derivatives as activators of neddylation pathway to inhibit the tumor progression in vitro Xuan WangSumeng GuanMoran Sun Original Research Article 15 February 2024 Pages: 504 - 517
Selectivity of N(2)-substituted oxotriazinoindole aldose reductase inhibitors is determined by the interaction pattern with Pro301-Arg312 loop of aldehyde reductase Lucia KováčikováSunil GaikwadMilan Štefek Original Research Article Open access 14 February 2024 Pages: 492 - 503
Novel biologically active pyridine derivatives: Synthesis, structure characterization, in vitro antimicrobial evaluation and structure-activity relationship Mohamed A. ElsayedAlshaimaa M. ElsayedFarid M. Sroor Original Research Article Open access 14 February 2024 Pages: 476 - 491
Benzocaine-N-acylindoline conjugates: synthesis and antiviral activity against Coxsackievirus B3 Alexandrina S. VolobuevaAnton A. ShetnevSergey V. Baykov Original Research Article 13 February 2024 Pages: 464 - 475
Exploring the latest breakthroughs in rhodesain inhibitors for African trypanosomiasis Diego Eidy ChibaGuilherme Felipe dos Santos FernandesCauê Benito Scarim Review Article 02 February 2024 Pages: 354 - 369
Unveiling the potential of prodrug and drug-conjugate strategies in treatment of diabetes mellitus and its complications Neha V. BhilareRushikesh ShedgeAjinkya More Review Article 29 January 2024 Pages: 337 - 353
Synthesis of adamantane-monoterpene conjugates with 1,3,4-thiadiazol-2(3H)-imine linker and evaluation of their inhibitory activity against TDP1 Aldar A. MunkuevAlexandra L. ZakharenkoOlga I. Lavrik Original Research Article 12 January 2024 Pages: 324 - 335
Identification of α-mangostin as a potent inhibitor of β-lactamase OXA-48 Wenhui ChengYuejuan ZhangYi Wan Original Research Article 10 January 2024 Pages: 314 - 323
Rehmannia glutinosa polysaccharides: a review on structure-activity relationship and biological activity Qianqian CaoZhixuan WangChunhong Dong Review Article 10 January 2024 Pages: 254 - 267
Polyketides from Neohelicosporium griseum: structure assignment and bioactivity investigation Lijuan ZhangJian MaRuvishika S. Jayawardena Original Research Article 04 January 2024 Pages: 308 - 313
Indazole derivatives as selective inhibitors of butyrylcholinesterase with effective blood-brain-barrier permeability profile Asuka Joy TobuseChristine Shing Wei LawKeng Yoon Yeong Original Research Article 30 December 2023 Pages: 298 - 307
Research progress on the mechanism of anti-myocardial infarction effect and clinical application of effective components of Salvia miltiorrhiza Xin ZhangZhiying BianYuhong Liu Review Article 30 December 2023 Pages: 239 - 253
Increased rigidity and bioisosteric replacement in the design, synthesis and preliminary evaluation of novel, functionalized 3,3-dialkyl-γ-butyrolactones as sigma-2 ligands Benjamin E. BlassRong GaoDaniel J. Canney Original Research Article 29 December 2023 Pages: 287 - 297
Synthesis and pharmacological evaluation of novel coumarin based triazolyl glycoconjugates as potential antibacterial and anti-proliferative agents Surendra JatavRanjit SinghBhuwan B. Mishra Original Research Article 28 December 2023 Pages: 276 - 286
Self-assembled amphiphilic bipyridine and bisquinoline cisplatin analogues: synthesis and anticancer properties Gabriel A. GonzalezJavier Hernandez-OrtegaJuan C. Noveron Original Research Article 23 December 2023 Pages: 268 - 275
Bioactivities and the structural modification of Parthenolide: a review Jie WuXiaoqian WangPing Gong Review Article 23 December 2023 Pages: 221 - 238
A concise review on anti-breast cancer effectiveness of s-triazines through EGFR kinase inhibition Pooja TandelRachana UpadhyayAmit B. Patel Review Article 21 December 2023 Pages: 47 - 65
Design, synthesis and evaluation of aurone and indanone derivatives as novel antitumor agents Baoxing XieGulmira TurduHaji Akber Aisa Original Research Article 20 December 2023 Pages: 201 - 220
Design, synthesis, molecular docking, and biological activity of pyrazolo[3,4-b]pyridines as promising lead candidates against Mycobacterium tuberculosis H. Surya Prakash RaoR. GunasundariJayaraman Muthukumaran Original Research Article 19 December 2023 Pages: 177 - 200
Pyrrolobenzodiazepines: natural sources, therapeutic uses, and future in neurological treatments Hadi ObajiAbbas G. ShilabinMohamed A. Ibrahim Review Article 18 December 2023 Pages: 36 - 46
Indazole derivatives as novel inhibitors of monoamine oxidase and D-amino acid oxidase Chezélle StearAnél PetzerJacobus P. Petzer Original Research Article Open access 15 December 2023 Pages: 164 - 176
Computer-aided design, synthesis and evaluation of new SARS-CoV-2 Mpro inhibitors based on 1,5,6,7-tetrahydro-4H-indazol-4-one scaffold Yuri A. PivenVeronica G. ZinovichFedor A. Lakhvich Original Research Article 11 December 2023 Pages: 151 - 163
Discovery of novel fatty acid amide hydrolase (FAAH) inhibitors as anti-Alzheimer’s agents through pharmacophore-based virtual screening, molecular docking and experimental validation Smita JainSwapnil SharmaJaiprakash Sharma Original Research Article 09 December 2023 Pages: 136 - 150
FTase inhibitors and cancer: prospects for use in targeted therapies Ming-tao XiaLing YuShuai Li Review Article 09 December 2023 Pages: 21 - 35
Enantioselectivity of pinene against Leishmania amazonensis Ingrid S. AdãoAndreza R. GarciaIgor A. Rodrigues Original Research Article 25 November 2023 Pages: 127 - 135
One-pot synthesis and in vitro bioactivity of novel 4-aminopyrazolo[3,4-b]pyridine derivatives as potential antimicrobial compounds Ranjana AggarwalSuresh KumarDeepansh Sharma Original Research Article 23 November 2023 Pages: 117 - 126
Characterization of novel angiotensin-I converting enzyme inhibitory peptides derived from Taiwan red quinoa (Chenopodium formosanum Koidz.) seed proteins using two sequential bioassay-guided fractionations Dininurilmi Putri SulemanChristoper Caesar Yudho SutopoJue-Liang Hsu Original Research Article 23 November 2023 Pages: 107 - 116
