1. Changes in the Treatment of Primary Esophageal Motility Disorders Imposed by the New Classification for Esophageal Motility Disorders on High Resolution Manometry (Chicago Classification 4.0)

   • Fernando A. M. Herbella
   • Leonardo M. Del Grande
   • Marco G. Patti

   Commentary Open access 27 March 2021 Pages: 2017 - 2026

   

2. Comparison of the Long-Acting GnRH Agonist Follicular Protocol with the GnRH Antagonist Protocol in Women Undergoing In Vitro Fertilization: A Systematic Review and Meta-analysis

   • Rui Yang
   • Yichun Guan
   • Rong Li

   Review Open access 02 March 2021 Pages: 2027 - 2037

   

3. Afatinib as First-Line Treatment in Asian Patients with EGFR Mutation-Positive NSCLC: A Narrative Review of Real-World Evidence

   • Shun Lu
   • Jin-Yuan Shih
   • Yongfeng Yu

   Review Open access 17 March 2021 Pages: 2038 - 2053

4. The Role of Purported Mucoprotectants in Dealing with Irritable Bowel Syndrome, Functional Diarrhea, and Other Chronic Diarrheal Disorders in Adults

   • Carmen Alonso-Cotoner
   • Mar Abril-Gil
   • Javier Santos

   Review Open access 18 March 2021 Pages: 2054 - 2076

   

5. The Automatic Substitution of Biosimilars: Definitions of Interchangeability are not Interchangeable

   • Anita Afzali
   • Daniel Furtner
   • Philip J. Molloy

   Review Open access 21 March 2021 Pages: 2077 - 2093

   

6. New Avenues for Treatment and Prevention of Drug-Induced Steatosis and Steatohepatitis: Much More Than Antioxidants

   • Mauro Cataldi
   • Vincenzo Citro
   • Giovanni Tarantino

   Review Open access 24 March 2021 Pages: 2094 - 2113

   

7. A Review of Robotic and OCT-Aided Systems for Vitreoretinal Surgery

   • Elan Z. Ahronovich
   • Nabil Simaan
   • Karen M. Joos

   Review Open access 03 April 2021 Pages: 2114 - 2129

   

8. Perspectives on Precision Medicine Approaches to NAFLD Diagnosis and Management

   • Amedeo Lonardo
   • Juan Pablo Arab
   • Marco Arrese

   Review Open access 07 April 2021 Pages: 2130 - 2158

   

9. Homozygous Familial Hypercholesterolemia (HoFH) in Saudi Arabia and Two Cases of Lomitapide Use in a Real-World Setting

   • Moeber Mahzari
   • Hawazen Zarif

   Review Open access 07 April 2021 Pages: 2159 - 2169

   

10. Advances in Clinical Cardiology 2020: A Summary of Key Clinical Trials

    • Aileen Kearney
    • Katie Linden
    • Ian B. A. Menown

    Review Open access 12 April 2021 Pages: 2170 - 2200

    

11. Sodium-Glucose Cotransporter 2 Inhibitors in Patients with Non-Diabetic Chronic Kidney Disease

    • Akira Mima

    Review 16 April 2021 Pages: 2201 - 2212

    

12. Effectiveness of Eribulin in Metastatic Breast Cancer: 10 Years of Real-World Clinical Experience in the United States

    • Sarah S. Mougalian
    • Jonathan K. Kish
    • Bruce A. Feinberg

    Original Research Open access 24 January 2021 Pages: 2213 - 2225

    

13. Correction to: Effectiveness of Eribulin in Metastatic Breast Cancer: 10 Years of Real-World Clinical Experience in the United States

    • Sarah S. Mougalian
    • Jonathan K. Kish
    • Bruce A. Feinberg

    Correction Open access 07 April 2021 Pages: 2226 - 2228

    

14. Real-World Prescription Pattern and Healthcare Cost Among Patients with Ulcerative Colitis in Japan: A Retrospective Claims Data Analysis

    • Celine Miyazaki
    • Takuya Sakashita
    • Shingo Kato

    Original Research Open access 30 January 2021 Pages: 2229 - 2247

    

15. Correction to: Real-World Prescription Pattern and Healthcare Cost Among Patients with Ulcerative Colitis in Japan: A Retrospective Claims Data Analysis

    • Celine Miyazaki
    • Takuya Sakashita
    • Shingo Kato

    Correction Open access 18 March 2021 Pages: 2248 - 2248

16. Effectiveness and Safety of COPD Maintenance Therapy with Tiotropium/Olodaterol versus LABA/ICS in a US Claims Database

    • Jennifer K. Quint
    • Jukka Montonen
    • Marc Miravitlles

    Original Research Open access 15 March 2021 Pages: 2249 - 2270

    

17. Non-Inferiority of a Single Injection of Sodium Hyaluronate Plus Sorbitol to Hylan G-F20: A 6-Month Randomized Controlled Trial

    • Bernard Cortet
    • Sandrine Lombion
    • Olivier Bruyère

    Original Research Open access 16 March 2021 Pages: 2271 - 2283

    

18. Assessment of Healthcare Professionals’ Knowledge and Understanding of the Risk of Blood Typing Interference with Daratumumab: A Survey of 12 European Countries

    • Mathieu Rosé
    • Intissar Bourahla
    • Massoud Toussi

    Original Research 16 March 2021 Pages: 2284 - 2293

    

19. Effect of Anti-CMV Therapy at Different Stages on Retinal Detachment in Patients with AIDS and CMVR

    • Lian-Yong Xie
    • Chao Chen
    • Wen-Bin Wei

    Original Research 17 March 2021 Pages: 2294 - 2301

    

20. The Correlation Between Urinary Sodium Excretion and Blood Pressure in Hospitalized Adult Patients with Hypertension

    • Li-qin Duan
    • Qiong Li
    • Qing-hua Han

    Original Research 19 March 2021 Pages: 2302 - 2314

    

21. A Retrospective Cohort Study of Sublingual Immunotherapy with Standardized Dermatophagoides farinae Drops for Allergic Rhinitis

    • Xingkai Ma
    • Yu Zhang
    • Huijun Yang

    Original Research 19 March 2021 Pages: 2315 - 2322

22. Familial Hypercholesterolemia Identification Algorithm in Patients with Acute Cardiovascular Events in A Large Hospital Electronic Database in Bulgaria: A Call for Implementation

    • Ivo Petrov
    • Arman Postadzhiyan
    • Reneta Petkova

    Original Research Open access 23 March 2021 Pages: 2323 - 2338

    

23. Quality of Life and Work Productivity Improvements with Upadacitinib: Phase 2b Evidence from Patients with Moderate to Severe Crohn’s Disease

    • Laurent Peyrin-Biroulet
    • Edouard Louis
    • Subrata Ghosh

    Original Research Open access 23 March 2021 Pages: 2339 - 2352

    

24. Treatment Persistence and Adherence Among Patients With Psoriatic Arthritis Who Initiated Targeted Immune Modulators in the US: A Retrospective Cohort Study

    • Jessica A. Walsh
    • Qian Cai
    • Soumya D. Chakravarty

    Original Research Open access 23 March 2021 Pages: 2353 - 2364

    

25. Fixed Dose of Cemiplimab in Patients with Advanced Malignancies Based on Population Pharmacokinetic Analysis

    • Anne J. Paccaly
    • Michael R. Migden
    • Danny Rischin

    Original Research Open access 25 March 2021 Pages: 2365 - 2378

    

26. Cost-Effectiveness Analysis of Adding Daratumumab to a Regimen of Bortezomib, Melphalan, and Prednisone in Newly Diagnosed Multiple Myeloma

    • Xiaohui Zeng
    • Qiao Liu
    • Chongqing Tan

    Original Research 26 March 2021 Pages: 2379 - 2390

    

27. Middle East Treatment Strategies and Clinical Outcomes in Patients with Atrial Fibrillation: One-Year Follow-up Data from Garfield-AF Study

    • Begum Yetis Sayin
    • Wael Al Mahmeed
    • Ali Oto

    Original Research 27 March 2021 Pages: 2391 - 2405

    

28. An Open-Label Tolerability and Actual-Use Human Factors Study of Etrolizumab Autoinjector in Healthy Volunteers

    • Helen Tyrrell
    • Renato Ravanello
    • Swati Tole

    Original Research Open access 29 March 2021 Pages: 2406 - 2417

    

29. Comparable Pharmacokinetics, Safety, and Tolerability of Etrolizumab Administered by Prefilled Syringe or Autoinjector in a Randomized Trial in Healthy Volunteers

    • Wenhui Zhang
    • Helen Tyrrell
    • Meina Tao Tang

    Original Research Open access 29 March 2021 Pages: 2418 - 2434

    

30. The First 100 Cases of Two Innovations Combined: Video-Assisted Minimally Invasive Aortic Valve Replacement Through Right Anterior Mini-Thoracotomy Using a Novel Aortic Prosthesis

    • Ali El-Sayed Ahmad
    • Saad Salamate
    • Farhad Bakhtiary

    Original Research Open access 31 March 2021 Pages: 2435 - 2446

    

31. First-Line Atezolizumab for Metastatic NSCLC with High PD-L1 Expression: A United States-Based Cost-Effectiveness Analysis

    • Ye Peng
    • Xiaohui Zeng
    • Chongqing Tan

    Original Research 05 April 2021 Pages: 2447 - 2457

    

32. Clinical Burden of Concomitant Joint Disease in Psoriasis: A US-Linked Claims and Electronic Health Records Database Analysis

    • Michelle Skornicki
    • Patricia Prince
    • Anthony Louder

    Original Research Open access 05 April 2021 Pages: 2458 - 2471

    

33. Comparative Efficacy of Cabozantinib and Ramucirumab After Sorafenib for Patients with Hepatocellular Carcinoma and Alpha-fetoprotein ≥ 400 ng/mL: A Matching-Adjusted Indirect Comparison

    • Jörg Trojan
    • Patrick Mollon
    • Marino Venerito

    Original Research Open access 06 April 2021 Pages: 2472 - 2490

    

34. Real-World Data on the Adverse Metabolic Effects of Second-Generation Antipsychotics and Their Potential Determinants in Adult Patients: A Systematic Review of Population-Based Studies

    • Miquel Bernardo
    • Fernando Rico-Villademoros
    • Ricardo Gómez-Huelgas

    Original Research Open access 07 April 2021 Pages: 2491 - 2512

    

35. Sensitivity, Specificity and Accuracy of a Novel EEG-Based Objective Test, the Cognalyzer^®, in Detecting Cannabis Psychoactive Effects

    • Alison C. McDonald
    • Israel Gasperin Haaz
    • Dan Bosnyak

    Original Research Open access 07 April 2021 Pages: 2513 - 2531

    

36. Association of Treatment Intensity and Adherence to Lipid-Lowering Therapy with Major Adverse Cardiovascular Events Among Post-MI Patients in Germany

    • Ingo Ahrens
    • Artak Khachatryan
    • Eduard Sidelnikov

    Original Research Open access 08 April 2021 Pages: 2532 - 2541

    

37. Are The Applications of Tranexamic Acid in Reverse Hybrid Total Knee Arthroplasty (TKA) The Same as Those in Fully Cemented TKA?: A Randomized Controlled Trial

    • Shenqi Zhang
    • Fengyan Wang
    • Qingyun Xue

    Original Research 08 April 2021 Pages: 2542 - 2557

    

38. Healthcare Costs of Not Achieving Remission in Patients with Rheumatoid Arthritis in the United States: A Retrospective Cohort Study

    • Martin Bergman
    • Lili Zhou
    • Namita Tundia

    Original Research Open access 09 April 2021 Pages: 2558 - 2570

    

39. Tofacitinib in the Treatment of Moderate-to-Severe Rheumatoid Arthritis in China: A Cost-Effectiveness Analysis Based on a Mapping Algorithm Derived from a Chinese Population

    • Chongqing Tan
    • Sini Li
    • Xiaomin Wan

    Original Research 10 April 2021 Pages: 2571 - 2585

    

40. Incidence of Infections and Malignancy Among Elderly Male Patients with IBD Exposed to Vedolizumab, Prednisone, and 5-ASA Medications: A Nationwide Retrospective Cohort Study

    • Nabeel Khan
    • Tyler Pernes
    • Yu-Xiao Yang

    Original Research 12 April 2021 Pages: 2586 - 2598

41. Can Thoracic Ultrasound on Admission Predict the Outcome of Critically Ill Patients with SARS-CoV-2? A French Multi-Centric Ancillary Retrospective Study

    • Gary Duclos
    • Florian Bazalguette
    • Laurent Zieleskiewicz

    Original Research 14 April 2021 Pages: 2599 - 2612

    

42. Cost-Effectiveness of Pembrolizumab Regimens for the First-Line Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma in Argentina

    • Victoria Wurcel
    • Diana Chirovsky
    • Jyotika Gandhi

    Original Research Open access 15 April 2021 Pages: 2613 - 2630

    

43. Budget Impact Analysis of Vericiguat for the Treatment of Chronic Heart Failure with Reduced Ejection Fraction Following a Worsening Event

    • Adnan Alsumali
    • Dominik Lautsch
    • Laurence M. Djatche

    Original Research Open access 16 April 2021 Pages: 2631 - 2643

    

44. Real-World Outcomes Among US Veterans Health Administration Patients Newly Diagnosed with Metastatic Renal Cell Carcinoma and Treated with First-Line Monotherapy

    • Abhijeet Bhanegaonkar
    • Shivani Pandya
    • Hemant Phatak

    Original Research Open access 17 April 2021 Pages: 2644 - 2661

    

45. The Application of Core Needle Biopsy Through the Trocar Hole in the Surgical Operation of Endoscopically Unresectable Giant Colon Polyps: A Systematic Review Study

    • Chun-bo Kang
    • Xu-bin Li
    • Tie-jun Liu

    Original Research 17 April 2021 Pages: 2662 - 2672

46. Effectiveness and Safety of Romiplostim Among Patients with Newly Diagnosed, Persistent and Chronic Immune Thrombocytopenia in European Clinical Practice

    • Snell Taylor Sara J.
    • Carrie M. Nielson
    • Leah J. McGrath

    Original Research Open access 18 April 2021 Pages: 2673 - 2688

    

47. A Clinical and Budgetary Impact Analysis of Introducing Sugammadex for Routine Reversal of Neuromuscular Blockade in a Hypothetical Cohort in the US

    • Yiling Jiang
    • Lori D. Bash
    • Leif Saager

    Original Research Open access 19 April 2021 Pages: 2689 - 2708

    

48. Mortality in Patients with COVID-19 on Renin Angiotensin System Inhibitor Long-Term Treatment: An Observational Study Showing that Things Are Not Always as They Seem

    • Massimo Cugno
    • Roberta Gualtierotti
    • Flora Peyvandi

    Brief Report 01 April 2021 Pages: 2709 - 2716

    

49. Fertility-Sparing Treatment for Atypical Endometrial Hyperplasia and Endometrial Cancer: A Cochrane Systematic Review Protocol

    • Maria-Eulalia Fernandez-Montoli
    • Jordi Sabadell
    • Nayanar-Adela Contreras-Perez

    Study Protocol 08 April 2021 Pages: 2717 - 2731

50. Recognising Colorectal Cancer in Primary Care

    • Natalia Calanzani
    • Aina Chang
    • Fiona M. Walter

    Practical Approach Open access 17 April 2021 Pages: 2732 - 2746