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Current Understanding Realities of Umbilical Cord Stem Cells Biology and Future Perspectives in Clinical Application

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Perinatal Tissue-Derived Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

In the recent years from variety of tissues, stem cells have been isolated but seem to be more concerning to mesenchymal stem cells (MSCs). Mesenchymal stem cells (MSCs) from bone marrow, adult organs, and fetuses show the disadvantages of ethical constraints, invasive isolation, and low cell numbers, and there are the clinical hurdles of potential immunorejection and tumorigenesis in embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), respectively. To overcome these limitations, the potential of fetal stem cells derived from birth-associated tissues has been investigated. Mesenchymal stem cells have also been reported in some compartments of the umbilical cord (UC-MSCs) including umbilical blood vessel adventia and endothelium, amnion, subamnion, Wharton’s jelly, perivascular region. UC-MSCs are noncontroversial and ease of sourcing cells. These cells can be harvested painlessly in abundance and have higher rate of proliferation, possess stemness properties, differentiation abilities, immunosuppressive, and do not induce teratomas and have anticancer properties. These advantages make them ideal for their use in cell-based therapies and treatment of cancers. In this chapter, we will at first give an overview of the biology and phenotypic characteristics, then provide an outline of the recent findings related to UC-MSC therapeutic application for the treatment of malignant and nonmalignant hematopoietic and nonhematopoietic diseases.

The original version of this chapter was revised. An erratum to this chapter can be found at DOI 10.1007/978-3-319-46410-7_12

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-46410-7_12

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Authors and Affiliations

  1. Department of Tissue Engineering and Applied Cell Sciences, Faculty of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Somayeh Ebrahimi-Barough Ph.D. & Jafar Ai

  2. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Reza Rahbarghazi

  3. Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

    Reza Rahbarghazi

  4. ENT and Head & Neck Research Center and Department, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

    Zohreh Bagher

  5. Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran

    Elham Hoveizi

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  1. Somayeh Ebrahimi-Barough Ph.D.
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  2. Reza Rahbarghazi
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  3. Zohreh Bagher
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  4. Jafar Ai
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  5. Elham Hoveizi
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Correspondence to Somayeh Ebrahimi-Barough Ph.D. .

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  1. Endocrinology and Metabolism Research Center Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences & Brain and Spinal Cord Injury Research Center Tehran University of Medical Sciences, Tehran, Iran

    Babak Arjmand

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Ebrahimi-Barough, S., Rahbarghazi, R., Bagher, Z., Ai, J., Hoveizi, E. (2016). Current Understanding Realities of Umbilical Cord Stem Cells Biology and Future Perspectives in Clinical Application. In: Arjmand, B. (eds) Perinatal Tissue-Derived Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-46410-7_6

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