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Changes in Cerebral Blood Flow and Diffusion-Weighted Imaging Lesions After Intracerebral Hemorrhage

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Abstract

Intracerebral hemorrhage (ICH) is a common subtype of stroke and places a great burden on the family and society with a high mortality and disability rate and a poor prognosis. Many findings from imaging and pathologic studies have suggested that cerebral ischemic lesions visualized on diffusion-weighted imaging (DWI) in patients with ICH are not rare and are generally considered to be associated with poor outcome, increased risk of recurrent (ischemic and hemorrhagic) stroke, cognitive impairment, and death. In this review, we describe the changes in cerebral blood flow (CBF) and DWI lesions after ICH and discuss the risk factors and possible mechanisms related to the occurrence of DWI lesions, such as cerebral microangiopathy, cerebral atherosclerosis, aggressive early blood pressure lowering, hyperglycemia, and inflammatory response. We also point out that a better understanding of cerebral DWI lesions will be a key step toward potential therapeutic interventions to improve long-term recovery for patients with ICH.

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Funding

This review was supported by grants from the National Natural Science Foundation of China (82071330, 81901219) and Hubei Provincial Department of Science & Technology (2021BCA109).

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Authors and Affiliations

  1. Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, NO, China

    Jingfei Yang, Jie Jing, Shiling Chen, Xia Liu, Yingxin Tang, Chao Pan & Zhouping Tang

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  1. Jingfei Yang
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  2. Jie Jing
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  3. Shiling Chen
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  4. Xia Liu
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  5. Yingxin Tang
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  6. Chao Pan
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  7. Zhouping Tang
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Contributions

JY, CP, and ZT conceived the review. JY performed the literature search and wrote the paper, and SC, XL, and JJ edited language. YT, CP, and ZT reviewed and edited the manuscript before submission. All authors have read and approved the final manuscript.

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Correspondence to Chao Pan or Zhouping Tang.

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Yang, J., Jing, J., Chen, S. et al. Changes in Cerebral Blood Flow and Diffusion-Weighted Imaging Lesions After Intracerebral Hemorrhage. Transl. Stroke Res. 13, 686–706 (2022). https://doi.org/10.1007/s12975-022-00998-6

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  • DOI: https://doi.org/10.1007/s12975-022-00998-6

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