Correction: Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food Gerhard EisenbrandAndrea BuettnerJan G. Hengstler Correction Open access 23 May 2024
Glutathione conjugation of sesquimustard: in vitro investigation of potential biomarkers Muharrem CenkHavva Bekiroğlu AtaşSuna Sabuncuoğlu Analytical Toxicology Open access 23 May 2024
Mechanistic screening of reproductive toxicity in a novel 3D testicular co-culture model shows significant impairments following exposure to low-dibutyl phthalate concentrations Radwa AlmamounPaula PierozanOskar Karlsson Reproductive Toxicology Open access 20 May 2024
Neurotoxicity of crack cocaine exposure: evidence from a systematic review of in vitro and in vivo studies Raphael Caio Tamborelli GarciaLidia Emmanuela Wiazowski SpeltaTania Marcourakis Review Article 20 May 2024
Two novel in vitro assays to screen chemicals for their capacity to inhibit thyroid hormone transmembrane transporter proteins OATP1C1 and OAT4 Fabian WagenaarsPeter CenijnTimo Hamers In vitro systems Open access 18 May 2024
A novel support vector machine-based 1-day, single-dose prediction model of genotoxic hepatocarcinogenicity in rats Min GiShugo SuzukiHideki Wanibuchi Genotoxicity and Carcinogenicity 18 May 2024
Molecular mechanisms of environmental pollutant-induced cartilage damage: from developmental disorders to osteoarthritis Anatoly V. SkalnyMichael AschnerAlexey A. Tinkov Review Article 17 May 2024
From hazard to risk prioritization: a case study to predict drug-induced cholestasis using physiologically based kinetic modeling Véronique M. P. de BruijnIvonne M. C. M. Rietjens Organ Toxicity and Mechanisms Open access 17 May 2024
Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition Valentina FogalFilippos MichopoulosMuireann Coen Toxicogenomics and Omics Technologies Open access 17 May 2024
Screening for ferroptosis genes related to endometrial carcinoma and predicting of targeted drugs based on bioinformatics Rui WangWei LangLi Guo Genotoxicity and Carcinogenicity 17 May 2024
Associations among global long interspersed nuclear element-1 DNA methylation, metal exposure, and chronic kidney disease Yu-Mei HsuehMei-Chieh ChenYa-Li Huang Organ Toxicity and Mechanisms 16 May 2024
Formation of functional, extended bile canaliculi, and increased bile acid production in sandwich-cultured human cryopreserved hepatocytes using commercially available culture medium Shinichiro HoriuchiYukie KurodaSeiichi Ishida In vitro systems Open access 16 May 2024
Cannabidivarin and cannabigerol induce unfolded protein response and angiogenesis dysregulation in placental trophoblast HTR-8/SVneo cells Patrícia AlvesCristina AmaralGeorgina Correia-da-Silva Molecular Toxicology Open access 15 May 2024
The role of cellular senescence in neurodegenerative diseases Yating WangKamil KucaKlaudia Jomova Review Article Open access 15 May 2024
The entactogen 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) as a treatment aid in psychotherapy and its safety concerns Brian A. Baldo Review Article 14 May 2024
Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures Milos MihajlovicSybren De BoeverMathieu Vinken Organ Toxicity and Mechanisms Open access 14 May 2024
Carbon nanotubes conjugated with cisplatin activate different apoptosis signaling pathways in 2D and 3D-spheroid triple-negative breast cancer cell cultures: a comparative study Madalina Andreea BadeaMihaela BalasAnca Dinischiotu Nanotoxicology Open access 13 May 2024
Investigation of the intrinsic cannabinoid activity of hemp-derived and semisynthetic cannabinoids with β-arrestin2 recruitment assays—and how this matters for the harm potential of seized drugs Liesl K. JanssensKatleen Van UytfangheChristophe P. Stove In vitro systems 12 May 2024
Targeting gut microbiota for immunotherapy of diseases Ya-Jie YuXiao-Dong LiuYun Wang Review Article 09 May 2024
Systematic evaluation of high-throughput PBK modelling strategies for the prediction of intravenous and oral pharmacokinetics in humans René GeciDomenico GadaletaStephan Schaller In silico Open access 09 May 2024
Lack of CYP3A4 protein induction despite mRNA induction in primary hepatocytes exposed to rifabutin as a possible explanation for its low interaction risk in vivo Julie NillesDirk TheileStephanie Ruez Toxicokinetics and Metabolism 07 May 2024
The physiological and biochemical basis of potency thresholds modeled using human estrogen receptor alpha: implications for identifying endocrine disruptors Christopher J. BorgertLyle D. BurgoonJohn C. Matthews Molecular Toxicology Open access 05 May 2024 Pages: 1795 - 1807
Thresholds of adversity for endocrine disrupting substances: a conceptual case study Judy ChoiStefanie RotterAndreas Hensel Regulatory Toxicology Open access 05 May 2024
Functional metabolomics characterizes the contribution of farnesoid X receptor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome Aizhen XiongLonghui LuLi Yang Toxicogenomics and Omics Technologies 04 May 2024
Multi-omics bioactivity profile-based chemical grouping and read-across: a case study with Daphnia magna and azo dyes Hanna GruszczynskaRosemary E. BarnettMark R. Viant Toxicogenomics and Omics Technologies Open access 02 May 2024
The two faces of antibiotics: an overview of the effects of antibiotic residues in foodstuffs Merve Güdül Bacanlı Review Article Open access 30 April 2024 Pages: 1717 - 1725
Avoiding a reproducibility crisis in regulatory toxicology—on the fundamental role of ring trials Miriam N. JacobsSebastian HoffmannRobert Landsiedel Regulatory Toxicology Open access 30 April 2024
Biotransformation and toxicokinetics of 2-phenoxyethanol after oral exposure in humans: a volunteer study Elisabeth EckertThomas JägerThomas Göen Toxicokinetics and Metabolism Open access 26 April 2024 Pages: 1771 - 1780
The characteristics, occurrence, and toxicological effects of alternariol: a mycotoxin Iman SalehRanda ZeidanMohammed Abu-Dieyeh Review Article Open access 25 April 2024 Pages: 1659 - 1683
AKR1C2 genetic variants mediate tobacco carcinogens metabolism involving bladder cancer susceptibility Yanping XiaoYang ShenZhengdong Zhang Genotoxicity and Carcinogenicity 25 April 2024
In vitro to in vivo extrapolation to derive a metabolism factor for estimating the aggregate exposure to salicylic acid after dermal exposure of its esters Abdulkarim NajjarSebastien GrégoireEstefania Cardamone In vitro systems Open access 24 April 2024
Vascular endothelial dysfunction induced by 3-bromofluoranthene via MAPK-mediated-NFκB pro-inflammatory pathway and intracellular ROS generation Chien-Ying LeeSheng-Wen WuYu-Hsiang Kuan Organ Toxicity and Mechanisms Open access 18 April 2024
Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells Yuxi LiQiangen WuSi Chen Reproductive Toxicology Open access 17 April 2024
Characterizing the toxicological responses to inorganic arsenicals and their metabolites in immortalized human bladder epithelial cells Arpamas VachiraarunwongMin GiHideki Wanibuchi Inorganic Compounds 17 April 2024
The rat acute oral toxicity of trifluoromethyl compounds (TFMs): a computational toxicology study combining the 2D-QSTR, read-across and consensus modeling methods Xinyi LuXin WangGuohui Sun In silico 16 April 2024
Repeated-dose toxicity and toxicokinetic study of isobutylparaben in rats subcutaneously treated for 13 weeks Jung Dae LeeJin-Sook BaeKyu-Bong Kim Organ Toxicity and Mechanisms 15 April 2024
Harnessing machine learning to predict cytochrome P450 inhibition through molecular properties Hamza ZahidHilal TayaraKil To Chong In silico 15 April 2024
Tl(I) and Tl(III)-induce genotoxicity, reticulum stress and autophagy in PC12 Adh cells Damiana M. Salvatierra-FréchouSandra V. Verstraeten Inorganic Compounds 15 April 2024
Higher paracetamol levels are associated with elevated glucocorticoid concentrations in hair: findings from a large cohort of young adults Lydia Johnson-FergusonLilly ShanahanBoris B. Quednow Organ Toxicity and Mechanisms Open access 14 April 2024
Sub-acute oral exposure to lowest observed adverse effect level of nivalenol exacerbates atopic dermatitis in mice via direct activation of mitogen-activated protein kinase signal in antigen-presenting cells Reo MatsuzakaHiroki YamaguchiTomoki Fukuyama Immunotoxicology 14 April 2024
Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague–Dawley rats and Beagle dogs Sang-Jin ParkHeeseon ParkYong-Bum Kim Immunotoxicology 12 April 2024
Targeted ferritinophagy in gastrointestinal cancer: from molecular mechanisms to implications Zhaotian FengMuhua LuanYanfei Jia Review Article 11 April 2024
The role of genetic polymorphisms for inducing genotoxicity in workers occupationally exposed to benzene: a systematic review Thiago Guedes PintoThayza Aires DiasDaniel Araki Ribeiro Review Article 10 April 2024
Correction to: Cytotoxicity of Prymnesium parvum extracts and prymnesin analogs on epithelial fish gill cells RTgill-W1 and the human colon cell line HCEC-1CT Elisabeth VargaHélène-Christine PrauseDoris Marko Correction Open access 09 April 2024 Pages: 1965 - 1966
Interaction of the chemotherapeutic agent oxaliplatin and the tyrosine kinase inhibitor dasatinib with the organic cation transporter 2 Sara Ahmed EltayebJulia M. DresslerGiuliano Ciarimboli Molecular Toxicology Open access 08 April 2024
Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing Ji-Eun SeoYuan LeXiaoqing Guo Genotoxicity and Carcinogenicity Open access 07 April 2024 Pages: 1919 - 1935
Human metabolism of four synthetic benzimidazole opioids: isotonitazene, metonitazene, etodesnitazene, and metodesnitazene Omayema TaoussiDiletta BerardinelliJeremy Carlier Toxicokinetics and Metabolism Open access 06 April 2024
Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure Baixiu ZhengYanrong ZhengZhong Chen Review Article 06 April 2024
Muller and mutations: mouse study of George Snell (a postdoc of Muller) fails to confirm Muller’s fruit fly findings, and Muller fails to cite Snell’s findings Edward J. CalabresePaul B. Selby Letter to the Editor, News and Views 04 April 2024 Pages: 1953 - 1963
The Bach1/HO-1 pathway regulates oxidative stress and contributes to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells and mice Yanwei WangJingru QiuHaiyan Lou Molecular Toxicology 04 April 2024 Pages: 1781 - 1794