Articles

1. PBPK modeling to predict the pharmacokinetics of venlafaxine and its active metabolite in different CYP2D6 genotypes and drug–drug interactions with clarithromycin and paroxetine

   • Chang-Keun Cho
   • Pureum Kang
   • Chang-Ik Choi

   Research Article 25 April 2024

   

2. Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress

   • Yajun Liu
   • Chenyao Li
   • Shutao Tan

   Review 17 April 2024

   

3. TNF receptor 2 knockout mouse had reduced lung cancer growth and schizophrenia-like behavior through a decrease in TrkB-dependent BDNF level

   • In Jun Yeo
   • Ji Eun Yu
   • Jin Tae Hong

   Research Article Open access 09 April 2024 Pages: 341 - 359

   

4. Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies

   • Youle Zheng
   • Jin Feng
   • Xu Wang

   Review 09 April 2024 Pages: 301 - 324

   

5. Potential biological functions and future perspectives of sialylated milk oligosaccharides

   • Thuy Le Lam Nguyen
   • Dung Van Nguyen
   • Kyung-Sun Heo

   Review 01 April 2024 Pages: 325 - 340

   

6. The novel psychoactive substance 25E-NBOMe induces reward-related behaviors via dopamine D1 receptor signaling in male rodents

   • Young-Jung Kim
   • Wun-A Kook
   • Choon-Gon Jang

   Research Article 29 March 2024 Pages: 360 - 376

   

7. Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application

   • Ya-Xiao Liu
   • Xiao-Mei Song
   • Wei Wang

   Review 16 March 2024 Pages: 165 - 218

   

8. Indole-3-acetic acid ameliorates dextran sulfate sodium-induced colitis via the ERK signaling pathway

   • Xinyan Qu
   • Yingying Song
   • Wei Liu

   Research Article 15 March 2024 Pages: 288 - 299

   

9. The potential of therapeutic strategies targeting mitochondrial biogenesis for the treatment of insulin resistance and type 2 diabetes mellitus

   • Wenwen Ding
   • Xiaoxue Yang
   • Ying Liu

   Review 14 March 2024 Pages: 219 - 248

   

10. New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis

    • Seulah Lee
    • Mina Jang
    • Ki Hyun Kim

    Research Article 28 February 2024 Pages: 272 - 287

    

11. Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways

    • Defeng Li
    • Jinling Fan
    • Guoyan Ren

    Research Article 24 January 2024 Pages: 127 - 145

    

12. Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

    • Yueyue Guan
    • Guohua Tang
    • Jun Tang

    Review Open access 15 January 2024 Pages: 146 - 164

    

13. Comparative metabolism of aschantin in human and animal hepatocytes

    • Min Seo Lee
    • Hyun Joo Shim
    • Hye Suk Lee

    Research Article 05 January 2024 Pages: 111 - 126

    

14. Physiologically based pharmacokinetic (PBPK) modeling of pitavastatin in relation to SLCO1B1 genetic polymorphism

    • Chang-Keun Cho
    • Ju Yeon Mo
    • Chang-Ik Choi

    Research Article 30 December 2023 Pages: 95 - 110

    

15. Antibody-drug conjugates in cancer therapy: innovations, challenges, and future directions

    • Shivangi Kumari
    • Sonam Raj
    • Jasvinder Singh Bhatti

    Review 28 December 2023 Pages: 40 - 65

    

16. PBPK modeling to predict the pharmacokinetics of pantoprazole in different CYP2C19 genotypes

    • Chang-Keun Cho
    • Eunvin Ko
    • Chang-Ik Choi

    Research Article 27 December 2023 Pages: 82 - 94

    

17. Dysregulation of histone deacetylases in ocular diseases

    • Jae Hyun Jun
    • Jun-Sik Kim
    • Dong-Gyu Jo

    Review 27 December 2023 Pages: 20 - 39

    

18. Gastric cancer and mesenchymal stem cell-derived exosomes: from pro-tumorigenic effects to anti-cancer vehicles

    • Maryam Dolatshahi
    • Ahmad Reza Bahrami
    • Maryam M. Matin

    Review 27 December 2023 Pages: 1 - 19

    

19. The PIN1-YTHDF1 axis promotes breast tumorigenesis via the m⁶A-dependent stabilization of AURKA mRNA

    • Pratikshya Shrestha
    • Garam Kim
    • Hong Seok Choi

    Research Article 26 December 2023 Pages: 66 - 81

    

20. Arsenic trioxide: applications, mechanisms of action, toxicity and rescue strategies to date

    • Meng Yan
    • Hao Wang
    • Wenwen Li

    Review 26 December 2023 Pages: 249 - 271

    

21. Physiologically based pharmacokinetic (PBPK) modeling to predict the pharmacokinetics of irbesartan in different CYP2C9 genotypes

    • Chang-Keun Cho
    • Pureum Kang
    • Chang-Ik Choi

    Research Article 08 December 2023 Pages: 939 - 953

    

22. Targeting dysregulated lipid metabolism in the tumor microenvironment

    • Do-Hee Kim
    • Na-Young Song
    • Hyungshin Yim

    Review Open access 07 December 2023 Pages: 855 - 881

    

23. Phytochemistry and pharmacology of plants in the genus Chaenomeles

    • Ruoling Xu
    • Mengting Kuang
    • Ning Li

    Review 07 December 2023 Pages: 825 - 854

    

24. Role of monocarboxylate transporter I/lactate dehydrogenase B-mediated lactate recycling in tamoxifen-resistant breast cancer cells

    • Min Chang Choi
    • Sang Kyum Kim
    • Keon Wook Kang

    Research Article 04 December 2023 Pages: 907 - 923

    

25. Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC

    • Xiaoping Song
    • Lina Wang
    • Daidi Fan

    Research Article 30 November 2023 Pages: 924 - 938

    

26. Human milk oligosaccharides 3′-sialyllactose and 6′-sialyllactose attenuate LPS-induced lung injury by inhibiting STAT1 and NF-κB signaling pathways

    • Yujin Jin
    • Hyesu Jeon
    • Kyung-Sun Heo

    Research Article 09 November 2023 Pages: 897 - 906

    

27. Death-associated protein kinase 1 phosphorylates MDM2 and inhibits its protein stability and function

    • Mi Zhang
    • Xindong Shui
    • Tae Ho Lee

    Research Article 07 October 2023 Pages: 882 - 896

    

28. 2-Geranyl-1-methoxyerythrabyssin II alleviates lipid accumulation and inflammation in hepatocytes through AMPK activation and AKT inhibition

    • Yiyuan Xi
    • Soeun Kim
    • Namki Cho

    Research Article 02 October 2023 Pages: 808 - 824

    

29. Exploring new histone deacetylase 6 inhibitors and their effects on reversing the α-tubulin deacetylation and cell morphology changes caused by methamphetamine

    • Sunil K. Gupta
    • Khan Hashim Ali
    • Young Ho Seo

    Research Article 30 September 2023 Pages: 795 - 807

    

30. Artemongolins A–K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities

    • Chong Shang
    • Yun-Bao Ma
    • Ji-Jun Chen

    Research Article 28 September 2023 Pages: 782 - 794

    

31. Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2

    • Da Eun Lee
    • Kun Hee Park
    • Ki Hyun Kim

    Research Article 26 September 2023 Pages: 771 - 781

    

32. Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs

    • Surapriya Surendranath Prabhu
    • Aathira Sujathan Nair
    • Saiprabha Vijayakumar Nirmala

    Review 26 September 2023 Pages: 723 - 743

    

33. Review on pharmacological effects of gastrodin

    • Guirong Xiao
    • Rong Tang
    • Yanhua Chen

    Review 25 September 2023 Pages: 744 - 770

    

34. Synthesis of Au–Ag bimetallic nanoparticles using Korean red ginseng (Panax ginseng Meyer) root extract for chemo-photothermal anticancer therapy

    • Gayeon Lee
    • You Jeong Lee
    • Youmie Park

    Research Article 17 August 2023 Pages: 659 - 678

    

35. Effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on the pharmacokinetics of tolperisone

    • Ji-Young Byeon
    • Chang‑Keun Cho
    • Yun Jeong Lee

    Research Article 20 September 2023 Pages: 713 - 721

    

36. Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction

    • Jie Xu
    • Aizhen Xiong
    • Li Yang

    Research Article 21 September 2023 Pages: 694 - 712

    

37. Androgen receptor and hyaluronan-mediated motility receptor as new molecular targets of baicalein: new molecular mechanisms for its anticancer properties

    • Mingyue Jiang
    • Suman Poudel
    • Kyung Song

    Research Article 10 September 2023 Pages: 679 - 693

    

38. Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway

    • Hyeonha Jang
    • Uttam Ojha
    • You Mie Lee

    Research Article 19 July 2023 Pages: 629 - 645

    

39. Ionically bridged dexamethasone sodium phosphate–zinc–PLGA nanocomplex in alginate microgel for the local treatment of ulcerative colitis

    • Aruzhan Saparbayeva
    • Juho Lee
    • Jin-Wook Yoo

    Research Article 03 August 2023 Pages: 646 - 658

    

40. Paeoniflorin increases the survival of Pseudomonas aeruginosa infected Caenorhabditis elegans at the immunosuppression stage by activating PMK-1, BAR-1, and EGL-1 signals

    • Le Zhang
    • Yuxing Wang
    • Dayong Wang

    Research Article 03 August 2023 Pages: 616 - 628

    

41. Stabilization of RNA G-quadruplexes in the SARS-CoV-2 genome inhibits viral infection via translational suppression

    • Maria Razzaq
    • Ji Ho Han
    • Kyeong Kyu Kim

    Research Article 10 August 2023 Pages: 598 - 615

    

42. Ubiquitin–proteasome system as a target for anticancer treatment—an update

    • Yeon Jung Kim
    • Yeonjoo Lee
    • Eun Joo Song

    Review 05 August 2023 Pages: 573 - 597

    

43. Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure–activity relationship, and biosynthesis

    • Peng Jiang
    • Xiujuan Fu
    • Hui Lei

    Review 30 June 2023 Pages: 449 - 499

    

44. Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases

    • Jin Kyung Seok
    • Minhyuk Kim
    • Joo Young Lee

    Review Open access 24 June 2023 Pages: 500 - 534

    

45. Paritaprevir ameliorates experimental acute lung injury in vitro and in vivo

    • Rui Ren
    • Xin Wang
    • Wanglin Jiang

    Research Article 12 June 2023 Pages: 564 - 572

    

46. Harnessing deep learning into hidden mutations of neurological disorders for therapeutic challenges

    • Sumin Yang
    • Sung-Hyun Kim
    • Jae-Yeol Joo

    Review 01 June 2023 Pages: 535 - 549

    

47. Recent advances in GPR35 pharmacology; 5-HIAA serotonin metabolite becomes a ligand

    • Dong-Soon Im

    Review 25 May 2023 Pages: 550 - 563

    

48. Effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide in healthy subjects

    • Pureum Kang
    • Chang-Keun Cho
    • Jung-Woo Bae

    Research Article 25 April 2023 Pages: 438 - 447

    

49. Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities

    • Ritwik Maiti
    • Bhumika Patel
    • Nirav Dhanesha

    Review 18 April 2023 Pages: 361 - 388

    

50. Phytochemistry and pharmacology of natural prenylated flavonoids

    • Hua-Wei Lv
    • Qiao-Liang Wang
    • Xing-Nuo Li

    Review 14 April 2023 Pages: 207 - 272