Abstract
Astragali Radix (A. Radix) is the dried root of Astragalus membranaceus var. mongholicus (Bge) Hsiao or Astragalus membranaceus (Fisch.) Bge., belonging to the family Leguminosae, which is mainly distributed in China. A. Radix has been consumed as a tonic in China for more than 2000 years because of its medicinal effects of invigorating the spleen and replenishing qi. Currently, more than 400 natural compounds have been isolated and identified from A. Radix, mainly including saponins, flavonoids, phenylpropanoids, alkaloids, and others. Modern pharmacological studies have shown that A. Radix has anti-tumor, anti-inflammatory, immunomodulatory, anti-atherosclerotic, cardioprotective, anti-hypertensive, and anti-aging effects. It has been clinically used in the treatment of tumors, cardiovascular diseases, and cerebrovascular complications associated with diabetes with few side effects and high safety. This paper reviewed the progress of research on its chemical constituents, pharmacological effects, clinical applications, developing applications, and toxicology, which provides a basis for the better development and utilization of A. Radix.
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Acknowledgements
The authors are grateful for the Shaanxi Provincial Science and Technology Department Project (2019ZDLSF04-03-02; 2024JC-YBQN-0860), National Natural Science Foundation of China (82104368), Program project for Shaanxi University of Chinese Medicine (Grant No. 2021GP27), Shaanxi University of Chinese Medicine Science and Technology Innovation Team Project (2019-YL12), Sci-Tech Innovation Talent System Construction Program of Shaanxi University of Chinese Medicine (No. 2023-CXTD-05), and Department of Education of Shaanxi Province (Grant No. 22JK0344).
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Liu, YX., Song, XM., Dan, LW. et al. Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application. Arch. Pharm. Res. 47, 165–218 (2024). https://doi.org/10.1007/s12272-024-01489-y
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DOI: https://doi.org/10.1007/s12272-024-01489-y