Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration Xiang FeiSooyun JungSeung-Yong Seo Review 20 June 2024
Interplay between YAP/TAZ and metabolic dysfunction-associated steatotic liver disease progression Na Young LeeMyeung Gi ChoiJa Hyun Koo Review Open access 14 June 2024
Antibacterial properties of natural products from marine fungi reported between 2012 and 2023: a review Ping WangXiaomei HuangTingting Wang Review 08 June 2024
Exploring molecular mechanisms, therapeutic strategies, and clinical manifestations of Huntington’s disease Alaa ShafieAmal Adnan AshourMd. Imtaiyaz Hassan Review 19 May 2024
Phytochemical and pharmacological properties of the genus Tamarix: a comprehensive review Fangjie LiWenli XieXianjun Fu Review 15 May 2024 Pages: 410 - 441
Potential of natural products in inflammation: biological activities, structure–activity relationships, and mechanistic targets Yajing GuoXuling PengFeng Qiu Review 13 May 2024 Pages: 377 - 409
Continuous TNF-α exposure in mammary epithelial cells promotes cancer phenotype acquisition via EGFR/TNFR2 activation Jin-Hee LeeSteffanus Pranoto HallisMi-Kyoung Kwak Research Article 11 May 2024 Pages: 465 - 480
PBPK modeling to predict the pharmacokinetics of venlafaxine and its active metabolite in different CYP2D6 genotypes and drug–drug interactions with clarithromycin and paroxetine Chang-Keun ChoPureum KangChang-Ik Choi Research Article 25 April 2024 Pages: 481 - 504
Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress Yajun LiuChenyao LiShutao Tan Review 17 April 2024 Pages: 442 - 464
TNF receptor 2 knockout mouse had reduced lung cancer growth and schizophrenia-like behavior through a decrease in TrkB-dependent BDNF level In Jun YeoJi Eun YuJin Tae Hong Research Article Open access 09 April 2024 Pages: 341 - 359
Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies Youle ZhengJin FengXu Wang Review 09 April 2024 Pages: 301 - 324
Potential biological functions and future perspectives of sialylated milk oligosaccharides Thuy Le Lam NguyenDung Van NguyenKyung-Sun Heo Review 01 April 2024 Pages: 325 - 340
The novel psychoactive substance 25E-NBOMe induces reward-related behaviors via dopamine D1 receptor signaling in male rodents Young-Jung KimWun-A KookChoon-Gon Jang Research Article 29 March 2024 Pages: 360 - 376
Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application Ya-Xiao LiuXiao-Mei SongWei Wang Review 16 March 2024 Pages: 165 - 218
Indole-3-acetic acid ameliorates dextran sulfate sodium-induced colitis via the ERK signaling pathway Xinyan QuYingying SongWei Liu Research Article 15 March 2024 Pages: 288 - 299
The potential of therapeutic strategies targeting mitochondrial biogenesis for the treatment of insulin resistance and type 2 diabetes mellitus Wenwen DingXiaoxue YangYing Liu Review 14 March 2024 Pages: 219 - 248
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis Seulah LeeMina JangKi Hyun Kim Research Article 28 February 2024 Pages: 272 - 287
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways Defeng LiJinling FanGuoyan Ren Research Article 24 January 2024 Pages: 127 - 145
Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management Yueyue GuanGuohua TangJun Tang Review Open access 15 January 2024 Pages: 146 - 164
Comparative metabolism of aschantin in human and animal hepatocytes Min Seo LeeHyun Joo ShimHye Suk Lee Research Article 05 January 2024 Pages: 111 - 126
Physiologically based pharmacokinetic (PBPK) modeling of pitavastatin in relation to SLCO1B1 genetic polymorphism Chang-Keun ChoJu Yeon MoChang-Ik Choi Research Article 30 December 2023 Pages: 95 - 110
Antibody-drug conjugates in cancer therapy: innovations, challenges, and future directions Shivangi KumariSonam RajJasvinder Singh Bhatti Review 28 December 2023 Pages: 40 - 65
PBPK modeling to predict the pharmacokinetics of pantoprazole in different CYP2C19 genotypes Chang-Keun ChoEunvin KoChang-Ik Choi Research Article 27 December 2023 Pages: 82 - 94
Dysregulation of histone deacetylases in ocular diseases Jae Hyun JunJun-Sik KimDong-Gyu Jo Review 27 December 2023 Pages: 20 - 39
Gastric cancer and mesenchymal stem cell-derived exosomes: from pro-tumorigenic effects to anti-cancer vehicles Maryam DolatshahiAhmad Reza BahramiMaryam M. Matin Review 27 December 2023 Pages: 1 - 19
The PIN1-YTHDF1 axis promotes breast tumorigenesis via the m6A-dependent stabilization of AURKA mRNA Pratikshya ShresthaGaram KimHong Seok Choi Research Article 26 December 2023 Pages: 66 - 81
Arsenic trioxide: applications, mechanisms of action, toxicity and rescue strategies to date Meng YanHao WangWenwen Li Review 26 December 2023 Pages: 249 - 271
Physiologically based pharmacokinetic (PBPK) modeling to predict the pharmacokinetics of irbesartan in different CYP2C9 genotypes Chang-Keun ChoPureum KangChang-Ik Choi Research Article 08 December 2023 Pages: 939 - 953
Targeting dysregulated lipid metabolism in the tumor microenvironment Do-Hee KimNa-Young SongHyungshin Yim Review Open access 07 December 2023 Pages: 855 - 881
Phytochemistry and pharmacology of plants in the genus Chaenomeles Ruoling XuMengting KuangNing Li Review 07 December 2023 Pages: 825 - 854
Role of monocarboxylate transporter I/lactate dehydrogenase B-mediated lactate recycling in tamoxifen-resistant breast cancer cells Min Chang ChoiSang Kyum KimKeon Wook Kang Research Article 04 December 2023 Pages: 907 - 923
Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC Xiaoping SongLina WangDaidi Fan Research Article 30 November 2023 Pages: 924 - 938
Human milk oligosaccharides 3′-sialyllactose and 6′-sialyllactose attenuate LPS-induced lung injury by inhibiting STAT1 and NF-κB signaling pathways Yujin JinHyesu JeonKyung-Sun Heo Research Article 09 November 2023 Pages: 897 - 906
Death-associated protein kinase 1 phosphorylates MDM2 and inhibits its protein stability and function Mi ZhangXindong ShuiTae Ho Lee Research Article 07 October 2023 Pages: 882 - 896
2-Geranyl-1-methoxyerythrabyssin II alleviates lipid accumulation and inflammation in hepatocytes through AMPK activation and AKT inhibition Yiyuan XiSoeun KimNamki Cho Research Article 02 October 2023 Pages: 808 - 824
Exploring new histone deacetylase 6 inhibitors and their effects on reversing the α-tubulin deacetylation and cell morphology changes caused by methamphetamine Sunil K. GuptaKhan Hashim AliYoung Ho Seo Research Article 30 September 2023 Pages: 795 - 807
Artemongolins A–K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities Chong ShangYun-Bao MaJi-Jun Chen Research Article 28 September 2023 Pages: 782 - 794
Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2 Da Eun LeeKun Hee ParkKi Hyun Kim Research Article 26 September 2023 Pages: 771 - 781
Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs Surapriya Surendranath PrabhuAathira Sujathan NairSaiprabha Vijayakumar Nirmala Review 26 September 2023 Pages: 723 - 743
Review on pharmacological effects of gastrodin Guirong XiaoRong TangYanhua Chen Review 25 September 2023 Pages: 744 - 770
Synthesis of Au–Ag bimetallic nanoparticles using Korean red ginseng (Panax ginseng Meyer) root extract for chemo-photothermal anticancer therapy Gayeon LeeYou Jeong LeeYoumie Park Research Article 17 August 2023 Pages: 659 - 678
Effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on the pharmacokinetics of tolperisone Ji-Young ByeonChang‑Keun ChoYun Jeong Lee Research Article 20 September 2023 Pages: 713 - 721
Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction Jie XuAizhen XiongLi Yang Research Article 21 September 2023 Pages: 694 - 712
Androgen receptor and hyaluronan-mediated motility receptor as new molecular targets of baicalein: new molecular mechanisms for its anticancer properties Mingyue JiangSuman PoudelKyung Song Research Article 10 September 2023 Pages: 679 - 693
Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway Hyeonha JangUttam OjhaYou Mie Lee Research Article 19 July 2023 Pages: 629 - 645
Ionically bridged dexamethasone sodium phosphate–zinc–PLGA nanocomplex in alginate microgel for the local treatment of ulcerative colitis Aruzhan SaparbayevaJuho LeeJin-Wook Yoo Research Article 03 August 2023 Pages: 646 - 658
Paeoniflorin increases the survival of Pseudomonas aeruginosa infected Caenorhabditis elegans at the immunosuppression stage by activating PMK-1, BAR-1, and EGL-1 signals Le ZhangYuxing WangDayong Wang Research Article 03 August 2023 Pages: 616 - 628
Stabilization of RNA G-quadruplexes in the SARS-CoV-2 genome inhibits viral infection via translational suppression Maria RazzaqJi Ho HanKyeong Kyu Kim Research Article 10 August 2023 Pages: 598 - 615
Ubiquitin–proteasome system as a target for anticancer treatment—an update Yeon Jung KimYeonjoo LeeEun Joo Song Review 05 August 2023 Pages: 573 - 597
Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure–activity relationship, and biosynthesis Peng JiangXiujuan FuHui Lei Review 30 June 2023 Pages: 449 - 499