1. Introduction

   • A. A. Epenetos

   EditorialNotes Pages: vii - vii

2. Linking radiosilver to monoclonal antibodies reduced by ascorbic acia

   • D. K. Hazra
   • V. L. Lahiri
   • Shabd Saran

   OriginalPaper Pages: 1 - 7

3. Removal of endotoxin from antibody preparations for clinical use

   • V. L. Lahiri
   • R. K. Srivastava
   • Manish Pathak

   OriginalPaper Pages: 9 - 14

4. Potent antitumor effects of an antitumor endothelial cell immunotoxin in a murine vascular targeting model

   • Francis J. Burrows
   • Jay P. Overholser
   • Philip E. Thorpe

   OriginalPaper Pages: 15 - 25

5. Recombinant proteins L and LG

   • R. Vola
   • A. Lombardi
   • M. Mariani

   OriginalPaper Pages: 27 - 36

6. Glioblastoma therapy by direct intralesional administration of I-131 radioiodine labeled antitenascin antibodies

   • P. Riva
   • A. Arista
   • N. Riva

   OriginalPaper Pages: 37 - 43

7. Mechanisms in removal of tumor by antibody

   • G. T. Stevenson
   • A. J. Bell
   • G. M. Mead

   OriginalPaper Pages: 45 - 50

8. Fusion protein mediated prodrug activation (FMPA) in vivo

   • K. Bosslet
   • J. Czech
   • D. Hoffmann

   OriginalPaper Pages: 51 - 63

9. Both V_H and V_L regions contribute to the antigenicity of anti-idiotypic antibody that mimics melanoma associated ganglioside GM₃

   • Shinji Kanda
   • Hiromitsu Takeyama
   • Reiko F. Irie

   OriginalPaper Pages: 65 - 74

10. Immunotargeting of urothelial cell carcinoma with intravesically administered Tc-99m labeled HMFG1 monoclonal antibody

    • J. Malamitsi
    • J. Zorzos
    • Ch. Proukakis

    OriginalPaper Pages: 75 - 81

11. ADEPT and related concepts

    • K. D. Bagshawe

    OriginalPaper Pages: 83 - 91

12. Clinical radioimmunolocalization with a rat monoclonal antibody directed against c-erbB-2

    • S. M. Allan
    • C. J. Dean
    • N. P. M. Sacks

    OriginalPaper Pages: 93 - 98

13. Use of technetium antigranulocyte monoclonal antibody Fab' fragments for the detection of osteomyelitis

    • S. J. Harwood
    • J. G. Camblin
    • R. G. Carroll

    OriginalPaper Pages: 99 - 107

14. Biosensor analysis of antigen-antibody interactions as a priority step in the generation of monoclonal bispecific antibodies

    • Alberto Horenstein
    • Claudio Poiesi
    • Fabio Malavasi

    OriginalPaper Pages: 109 - 117

15. Effect of a bifunctional monoclonal antibody directed against a tumor marker and doxorubicin on the growth of epidermoid vulvar carcinoma grafted in athymic mice

    • D. Morelli
    • S. Ménard
    • M. I. Colnaghi

    OriginalPaper Pages: 119 - 126

16. Conjugates of COL-1 monoclonal antibody and β-D-galactosidase can specifically kill tumor cells by generation of 5-fluorouridine from the prodrug β-D-galactosyl-5-fluorouridine

    • Ralph Abraham
    • Nureddin Aman
    • Richard Titmas

    OriginalPaper Pages: 127 - 133

17. Complete ablation of small squamous cell carcinoma xenografts with¹⁸⁶Re-labeled monoclonal antibody E48

    • Martijn Gerretsen
    • Gerard W. M. Visser
    • Guus A. M. S. van Dongen

    OriginalPaper Pages: 135 - 142

18. Anti-idotype and recombinant antigen in immunotherapy of colorectal cancer

    • D. Herlyn
    • R. Somasundaram
    • M. Mastrangelo

    OriginalPaper Pages: 143 - 153

19. Preclinical studies of monoclonal antibodies for intravesical radioimmunotherapy of human bladder cancer

    • Pamela J. Russell
    • Karyn Davis
    • Nicholas Pearce

    OriginalPaper Pages: 155 - 161

20. In vitro activity of immunoconjugates between cisplatin and an anti-CA125 monoclonal antibody on ovarian cancer cell lines

    • E. Beck
    • M. Hofmann
    • N. Lang

    OriginalPaper Pages: 163 - 173

21. Comparison of the cellular internalization of antibodies used either as immunotoxins or in ADEPT

    • D. C. Blakey
    • P. E. Pinder
    • A. F. Wright

    OriginalPaper Pages: 175 - 183

22. Comparison of two anthracycline-based prodrugs for activation by a monoclonal antibody-β-glucuronidase conjugate in the specific treatment of cancer

    • H. J. Haisma
    • M. van Muijen
    • E. Boven

    OriginalPaper Pages: 185 - 192

23. Analysis of antibody-enzyme conjugate clearance by investigation of prodrug and active drug in an ADEPT clinical study

    • C. J. Springer
    • G. K. Poon
    • K. D. Bagshawe

    OriginalPaper Pages: 193 - 207

24. Biological studies and potential therapeutic applications of monoclonal antibodies and small molecules reactive with theneu/c-erbB-2 protein

    • William C. Dougall
    • Mark I. Greene

    OriginalPaper Pages: 209 - 218

25. Antibody-directed enzyme prodrug therapy (ADEPT)

    • Surinder K. Sharma
    • Joan A. Boden
    • Kenneth D. Bagshawe

    OriginalPaper Pages: 219 - 228

26. Functional expression in mast cells of chimeric receptors with antibody specificity

    • Nathan L. Bach
    • Tova Waks
    • Zelig Eshhar

    OriginalPaper Pages: 229 - 236

27. Monoclonal antibodies and idiotypic network activation for ovarian carcinoma

    • U. Wagner
    • J. Reinsberg
    • D. Krebs

    OriginalPaper Pages: 237 - 242

28. Deoxyribonuclease I (DNase I)

    • H. Linardou
    • M. P. Deonarain
    • A. A. Epenetos

    OriginalPaper Pages: 243 - 248

29. Targeting phosphodiesterases as a strategy for killing tumor cells

    • Mahendra P. Deonarain
    • Agamemnon A. Epenetos

    OriginalPaper Pages: 249 - 257

30. Idiotypic cascades after injection of the monoclonal antibody OC125

    • B. C. Schultes
    • J. Reinsberg
    • H. J. Biersack

    OriginalPaper Pages: 259 - 266

31. Tumor targeting in a murine tumor xenograft model with the (sFv′)₂ divalent form of anti-c-erbB-2 single-chain Fv

    • James S. Huston
    • Gregory P. Adams
    • Louis M. Weiner

    OriginalPaper Pages: 267 - 278

32. Preclinical models for the evaluation of targeted therapies of metastatic disease

    • S. A. Eccles
    • G. Box
    • C. J. Dean

    OriginalPaper Pages: 279 - 291

33. Correlation of beta-camera imaging and immunohistochemistry in radioimmunotherapy using⁹⁰Y-labeled monoclonal antibodies in ovarian cancer animal models

    • Kalevi J. A. Kairemo
    • Kaj Ljunggren
    • Sven-Erik Strand

    OriginalPaper Pages: 293 - 300

34. Study of peripheral blood lymphocyte subset distribution and IL-2 receptor (IL-2 R) p55–p75 subunit expression in patients with cancer of different sites

    • G. Mantovani
    • A. Macciò
    • G. S. Del Giacco

    OriginalPaper Pages: 301 - 305

35. Combined use of¹¹¹In-labeled pentetreotide and three-step immunoscintigraphy with antichromogranin a monoclonal antibody in the diagnosis of pituitary adenomas

    • P. Magnani
    • G. Paganelli
    • F. Fazio

    OriginalPaper Pages: 307 - 313

36. Immunotoxin studies in a model of human T-cell acute lymphoblastic leukemia developed in severe combined immune-deficient mice

    • B. J. Morland
    • D. Boehm
    • D. J. Flavell

    OriginalPaper Pages: 315 - 329

37. Sequencing data of the antiglioma antibody MUC 2-63 and strategy for construction of chimeric antibodies

    • C. Hagel
    • M. Neumaier
    • D. Stavrou

    OriginalPaper Pages: 331 - 339