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Sequencing data of the antiglioma antibody MUC 2-63 and strategy for construction of chimeric antibodies

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Abstract

The murine monoclonal antibody MUC 2-63 detects a surface antigen expressed in human gliomas as demonstrated by means of immunohistochemistry and Western blot. In addition, MUC 2-63 has been successfully used in vivo for radioimaging in nude mice bearing glioma xenografts and in glioma patients. The genes coding for the variable regions of MUC 2-63 were isolated for construction of antibody derivatives with reduced immunogenic effects and of reduced size. DNA and protein sequencing data and strategy for construction of chimeric antibodies and single-chain Fv fragments are presented.

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Authors and Affiliations

  1. Department of Neuropathology, University of Hamburg, Martinistrasse 52, D-20246, Hamburg, Germany

    C. Hagel & D. Stavrou

  2. Department of Clinical Chemistry, University of Hamburg, Martinistrasse 52, D-20246, Hamburg, Germany

    M. Neumaier

Authors
  1. C. Hagel
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  2. M. Neumaier
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  3. D. Stavrou
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Hagel, C., Neumaier, M. & Stavrou, D. Sequencing data of the antiglioma antibody MUC 2-63 and strategy for construction of chimeric antibodies. Cell Biophysics 24, 331–339 (1994). https://doi.org/10.1007/BF02789244

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  • DOI: https://doi.org/10.1007/BF02789244

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