Articles

1. Sex Dimorphism in Pain Threshold and Neuroinflammatory Response: The Protective Effect of Female Sexual Hormones on Behavior and Seizures in an Allergic Rhinitis Model

   • Mohammad Elahi
   • Zahra Ebrahim Soltani
   • Ahmad Reza Dehpour

   Research 23 April 2024 Article: 16

   

2. Brain-Derived Exosomal CircRNAs in Plasma Serve as Diagnostic Biomarkers for Acute Ischemic Stroke

   • Xinli Jiang
   • Rui Zhang
   • Jun Wang

   RESEARCH 22 April 2024 Article: 15

   

3. JAK1/2 Regulates Synergy Between Interferon Gamma and Lipopolysaccharides in Microglia

   • Alexander P. Young
   • Eileen M. Denovan-Wright

   RESEARCH 20 April 2024 Article: 14

   

4. Endothelin-1-mediated Brainstem Glial Activation Produces Asthmatic Airway Vagal Hypertonia Via Enhanced ATP-P2X4 Receptor Signaling in Sprague–Dawley Rats

   • Yun Lin
   • Tian Liu
   • Jijiang Wang

   RESEARCH 13 April 2024 Article: 13

   

5. IL-6 Enhances the Activation of PI3K-AKT/mTOR-GSK-3β by Upregulating GRPR in Hippocampal Neurons of Autistic Mice

   • Heli Li
   • Xinyuan Wang
   • Yan Hao

   Research Open access 27 March 2024 Article: 12

   

6. Melatonin Enhanced Microglia M2 Polarization in Rat Model of Neuro-inflammation Via Regulating ER Stress/PPARδ/SIRT1 Signaling Axis

   • Hung-Chuan Pan
   • Cheng-Ning Yang
   • Meei-Ling Sheu

   Correspondence 26 March 2024 Article: 11

   

7. Perioperative Levels of IL8 and IL18, but not IL6, are Associated with Nucleus Basalis Magnocellularis Atrophy Three Months after Surgery

   • Maria Heinrich
   • Claudia Spies
   • Florian Lammers-Lietz

   RESEARCH Open access 14 March 2024 Article: 10

   

8. Activation of the CXCR4 Receptor by Chemokine CXCL12 Increases the Excitability of Neurons in the Rat Central Amygdala

   • Joanna Ewa Sowa
   • Krzysztof Tokarski
   • Grzegorz Hess

   Research 02 March 2024 Article: 9

   

9. Complement C3 From Astrocytes Plays Significant Roles in Sustained Activation of Microglia and Cognitive Dysfunctions Triggered by Systemic Inflammation After Laparotomy in Adult Male Mice

   • Ying Chen
   • John Man-Tak Chu
   • Raymond Chuen-Chung Chang

   RESEARCH Open access 01 March 2024 Article: 8

   

10. New Insights on NLRP3 Inflammasome: Mechanisms of Activation, Inhibition, and Epigenetic Regulation

    • Triveni kodi
    • Runali Sankhe
    • Anoop Kishore

    REVIEW Open access 29 February 2024 Article: 7

    

11. TPN10475 Constrains Effector T Lymphocytes Activation and Attenuates Experimental Autoimmune Encephalomyelitis Pathogenesis by Facilitating TGF-β Signal Transduction

    • Chun Wang
    • Xiangrui Jiang
    • Changsheng Du

    Research 27 February 2024 Article: 6

    

12. Heat Shock Protein 22 Attenuates Nerve Injury-induced Neuropathic Pain Via Improving Mitochondrial Biogenesis and Reducing Oxidative Stress Mediated By Spinal AMPK/PGC-1α Pathway in Male Rats

    • Longqing Zhang
    • Lin Liu
    • Wei Mei

    Research 06 February 2024 Article: 5

    

13. Potential Role of Bmal1 in Lipopolysaccharide-Induced Depression-Like Behavior and its Associated "Inflammatory Storm"

    • Dan-Dan Xu
    • Zhi-Qi Hou
    • Qing-Rong Xia

    RESEARCH 02 February 2024 Article: 4

    

14. VX-765 Alleviates Circadian Rhythm Disorder in a Rodent Model of Traumatic Brain Injury Plus Hemorrhagic Shock and Resuscitation

    • Yan Li
    • Yue Xin
    • Li-Min Zhang

    RESEARCH 01 February 2024 Article: 3

    

15. Doxycycline-Loaded Calcium Phosphate Nanoparticles with a Pectin Coat Can Ameliorate Lipopolysaccharide-Induced Neuroinflammation Via Enhancing AMPK

    • Suzan Awad AbdelGhany Morsy
    • Mona Hassan Fathelbab
    • Sahar A. Harby

    Research Open access 18 January 2024 Article: 2

    

16. Alleviating CB2-Dependent ER Stress and Mitochondrial Dysfunction Improves Chronic Cerebral Hypoperfusion-Induced Cognitive Impairment

    • Da Peng Wang
    • Kai Kang
    • Zhe Bao Wu

    Research Open access 12 January 2024 Article: 1

    

17. Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson’s Disease

    • Pranay Srivastava
    • Shuhei Nishiyama
    • Xiqun Chen

    Research Open access 19 December 2023 Pages: 704 - 717

    

18. β-Sitosterol Alleviates Neuropathic Pain by Affect Microglia Polarization through Inhibiting TLR4/NF-κB Signaling Pathway

    • Yachun Zheng
    • Jiaji Zhao
    • Guoping Zhao

    RESEARCH 02 December 2023 Pages: 690 - 703

    

19. Low-dose IL-2 Treatment Rescues Cognitive Deficits by Repairing the Imbalance Between Treg and Th17 Cells at the Middle Alzheimer’s Disease Stage

    • Lin Yuan
    • Lei Xie
    • Cui Lv

    RESEARCH 14 November 2023 Pages: 674 - 689

    

20. Sertraline Pre-Treatment Attenuates Hemorrhagic Transformation Induced in Rats after Cerebral Ischemia Reperfusion via Down Regulation of Neuronal CD163: Involvement of M1/M2 Polarization Interchange and Inhibiting Autophagy

    • Shimaa K. Mohamed
    • Amany A. E. Ahmed
    • Abeer Elkhoely

    RESEARCH Open access 13 November 2023 Pages: 657 - 673

    

21. Edaravone Confers Neuroprotective, Anti-inflammatory, and Antioxidant Effects on the Fetal Brain of a Placental-ischemia Mouse Model

    • Marwa Atallah
    • Toru Yamashita
    • Koji Abe

    RESEARCH 04 November 2023 Pages: 640 - 656

    

22. Elucidating the Therapeutic Utility of Olaparib in Sulfatide-Induced Human Astrocyte Toxicity and Neuroinflammation

    • Marianna Mekhaeil
    • Melissa Jane Conroy
    • Kumlesh Kumar Dev

    RESEARCH Open access 04 November 2023 Pages: 592 - 609

    

23. Autonomic Neuropathy is Associated with More Densely Interconnected Cytokine Networks in People with HIV

    • Steven Lawrence
    • Bridget R. Mueller
    • Jessica Robinson-Papp

    RESEARCH 04 November 2023 Pages: 563 - 572

    

24. GPNMB Ameliorates Neuroinflammation Via the Modulation of AMPK/NFκB Signaling Pathway After SAH in Mice

    • Tao Li
    • Yuansheng Zhang
    • Xiaoyang Lu

    RESEARCH Open access 03 November 2023 Pages: 628 - 639

    

25. Changes in Cerebrospinal Fluid, Liver and Intima-media-thickness Biomarkers in Patients with HIV-associated Neurocognitive Disorders Randomized to a Less Neurotoxic Treatment Regimen

    • Giacomo Stroffolini
    • Alessandro Lazzaro
    • Andrea Calcagno

    RESEARCH Open access 31 October 2023 Pages: 551 - 562

    

26. Prenatal SARS-CoV-2 Spike Protein Exposure Induces Autism-Like Neurobehavioral Changes in Male Neonatal Rats

    • Mumin Alper Erdogan
    • Miray Turk
    • Oytun Erbas

    RESEARCH 27 October 2023 Pages: 573 - 591

    

27. 5-HT4 Receptor is Protective for MPTP-induced Parkinson’s Disease Mice Via Altering Gastrointestinal Motility or Gut Microbiota

    • Chun Cui
    • Yun Shi
    • Yanqin Shen

    Research 02 October 2023 Pages: 610 - 627

    

28. SIRT2 Inhibition Rescues Neurodegenerative Pathology but Increases Systemic Inflammation in a Transgenic Mouse Model of Alzheimer’s Disease

    • Noemi Sola-Sevilla
    • Alberto Mesa-Lombardo
    • Elena Puerta

    RESEARCH Open access 12 September 2023 Pages: 529 - 550

    

29. PPARɑ Ligand Caudatin Improves Cognitive Functions and Mitigates Alzheimer’s Disease Defects By Inducing Autophagy in Mice Models

    • Senthilkumar Krishnamoorthi
    • Ashok Iyaswamy
    • Min Li

    RESEARCH 08 September 2023 Pages: 509 - 528

    

30. The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain

    • Elena Irollo
    • Bradley Nash
    • Olimpia Meucci

    RESEARCH Open access 04 September 2023 Pages: 495 - 508

    

31. Curcumin-activated Olfactory Ensheathing Cells Improve Functional Recovery After Spinal Cord Injury by Modulating Microglia Polarization Through APOE/TREM2/NF-κB Signaling Pathway

    • Chao Jiang
    • Zhe Chen
    • Dingjun Hao

    Research Open access 02 September 2023 Pages: 476 - 494

    

32. Pharmacological Inhibition of PTEN Rescues Dopaminergic Neurons by Attenuating Apoptotic and Neuroinflammatory Signaling Events

    • Aishwarya Mary Johnson
    • Sara Jose
    • Hariharan Saminathan

    ORIGINAL ARTICLE 17 August 2023 Pages: 462 - 475

    

33. Fatty Acid-Binding Protein 4 is Essential for the Inflammatory and Metabolic Response of Microglia to Lipopolysaccharide

    • Yoshiteru Kagawa
    • Yi Ling Low
    • Joseph A. Nicolazzo

    RESEARCH Open access 09 August 2023 Pages: 448 - 461

    

34. Natural Immunosuppressants as a Treatment for Chronic Insomnia Targeting the Inflammatory Response Induced by NLRP3/caspase-1/IL-1β Axis Activation: A Scooping Review

    • Zahra Aghelan
    • Somayeh Pashaee
    • Reza Khodarahmi

    INVITED REVIEW 08 August 2023 Pages: 294 - 309

    

35. Characterization of Depression- and Anxiety-Like Behaviours in a Mouse Model of Relapsing-Remitting Multiple Sclerosis

    • Diulle Spat Peres
    • Fernanda Tibolla Viero
    • Gabriela Trevisan

    Correspondence 01 August 2023 Pages: 235 - 247

    

36. Cyclophosphamide in the Treatment of Systemic Lupus Erythematosus-related Guillain-Barré Syndrome: A Systematic Review of Case Reports

    • Anji Xiong
    • Hongxu Cui
    • Xin Wei

    INVITED REVIEW 30 June 2023 Pages: 285 - 293

    

37. Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Improve Neuroinflammation and Cognition By Up-regulating IRS/PI3K/AKT Signaling Pathway in Diet-induced Obese Mice

    • Igor Henrique Rodrigues de Paiva
    • Rodrigo Soares da Silva
    • Christina Alves Peixoto

    RESEARCH 29 June 2023 Pages: 427 - 447

    

38. As a Potential Therapeutic Target, C1q Induces Synapse Loss Via Inflammasome-activating Apoptotic and Mitochondria Impairment Mechanisms in Alzheimer’s Disease

    • Pei-Pei Guan
    • Tong-Qi Ge
    • Pu Wang

    INVITED REVIEW 29 June 2023 Pages: 267 - 284

    

39. Impact of Adolescent Nicotine Exposure in Pre- and Post-natal Oxycodone Exposed Offspring

    • Adrian Flores
    • Austin Gowen
    • Gurudutt Pendyala

    Research 23 June 2023 Pages: 413 - 426

    

40. Ginsenoside Re Mitigates Photooxidative Stress-Mediated Photoreceptor Degeneration and Retinal Inflammation

    • Jie Chang
    • Yujue Wang
    • Yu Chen

    Research Open access 16 June 2023 Pages: 397 - 412

    

41. Ibrutinib Delays ALS Installation and Increases Survival of SOD1^G93A Mice by Modulating PI3K/mTOR/Akt Signaling

    • Chengyou Zheng
    • Weifen Li
    • Shupeng Li

    Research 16 June 2023 Pages: 383 - 396

    

42. Effect and Mechanism of Sodium Butyrate on Neuronal Recovery and Prognosis in Diabetic Stroke

    • Ting-ting Li
    • Deng-ming Zhao
    • Wen-zhi Li

    RESEARCH 15 June 2023 Pages: 366 - 382

    

43. The Node of Ranvier as an Interface for Axo-Glial Interactions: Perturbation of Axo-Glial Interactions in Various Neurological Disorders

    • Sonam Dolma
    • Abhijeet Joshi

    INVITED REVIEW 07 June 2023 Pages: 215 - 234

    

44. Zinc Ortho Methyl Carbonodithioate Improved Pre and Post-Synapse Memory Impairment via SIRT1/p-JNK Pathway against Scopolamine in Adult Mice

    • Rifat Jahan
    • Mohammad Yousaf
    • Dong-Qing Wei

    ORIGINAL ARTICLE 01 June 2023 Pages: 183 - 194

    

45. Maternal Immune Activation Induces Cortical Catecholaminergic Hypofunction and Cognitive Impairments in Offspring

    • Blanca Perez-Palomar
    • Amaia M. Erdozain
    • J. Javier Meana

    Research Open access 20 May 2023 Pages: 348 - 365

    

46. Cerebrospinal Fluid CXCL13 as Candidate Biomarker of Intrathecal Immune Activation, IgG Synthesis and Neurocognitive Impairment in People with HIV

    • Mattia Trunfio
    • Lorenzo Mighetto
    • Andrea Calcagno

    ORIGINAL ARTICLE 11 May 2023 Pages: 169 - 182

    

47. Role of Dysregulated Autophagy in HIV Tat, Cocaine, and cART Mediated NLRP3 Activation in Microglia

    • Seema Singh
    • Annadurai Thangaraj
    • Shilpa Buch

    RESEARCH 06 May 2023 Pages: 327 - 347

    

48. Long-term Stimulation of α7 Nicotinic Acetylcholine Receptor Rescues Hemorrhagic Neuron Loss via Apoptosis of M1 Microglia

    • Masatoshi Ohnishi
    • Aoi Machida
    • Atsuko Inoue

    ORIGINAL ARTICLE 05 May 2023 Pages: 160 - 168

    

49. L-carnitine Modulates Cognitive Impairment Induced by Doxorubicin and Cyclophosphamide in Rats; Insights to Oxidative Stress, Inflammation, Synaptic Plasticity, Liver/brain, and Kidney/brain Axes

    • Olivia Fayez Morid
    • Esther T. Menze
    • Mina Y. George

    RESEARCH Open access 04 May 2023 Pages: 310 - 326

    

50. Emphasizing the Crosstalk Between Inflammatory and Neural Signaling in Post-traumatic Stress Disorder (PTSD)

    • Anusha Govindula
    • Niraja Ranadive
    • Jayesh Mudgal

    Review Open access 25 April 2023 Pages: 248 - 266